Product image of Nervius (Pramipexole Dihydrochloride Monohydrate) supplied by GNH India

Nervius

Active Ingredient:
Pramipexole Dihydrochloride Monohydrate
Origin:
EU

Nervius (Pramipexole Dihydrochloride Monohydrate)

Pramipexole Dihydrochloride Monohydrate, the active ingredient in Nervius, is a dopamine agonist presented as an oral dosage form for oral use. It is employed to manage motor symptoms in Parkinson's disease and to alleviate symptoms of Restless Legs Syndrome in adult patients.

GNH India supplies Nervius as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Target Pharma Single Member Private Ltd

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Indications & Clinical Uses

Pramipexole acts on dopaminergic pathways to treat movement disorders and related conditions.

  • Parkinson's disease: improves motor control and reduces rigidity and tremor.
  • Restless Legs Syndrome: decreases the urge to move the legs and improves sleep quality.
  • Motor fluctuations in Parkinson's disease: lessens "off" periods and stabilises symptom control.

How It Works

  • Pramipexole selectively stimulates dopamine D2 and D3 receptors in the central nervous system, mimicking dopamine activity. By activating these receptors, it enhances dopaminergic neurotransmission, which helps restore the balance of motor pathways disrupted in Parkinson's disease and reduces the sensory discomfort associated with Restless Legs Syndrome.

Side Effects

Pramipexole may cause a range of adverse reactions, which vary in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Dizziness: sensation of light‑headedness, especially when standing.
  • Somnolence: increased sleepiness during the day.
  • Constipation: reduced bowel movements.
  • Headache: mild to moderate head pain.
  • Hallucinations: visual or auditory disturbances, more common in older patients.

Serious or Rare Side Effects

  • Impulse control disorders: compulsive gambling, shopping, or eating.
  • Orthostatic hypotension: sudden drop in blood pressure upon standing.
  • Sudden onset of sleep: unexpected sleep episodes.
  • Depression or suicidal thoughts: mood changes requiring immediate attention.
  • Severe allergic reactions: rash, swelling, or breathing difficulty.
  • Psychosis: severe confusion or delusional thinking.

Precautions & Warnings

Before initiating therapy with Nervius, consider the following safety measures.

  • Renal impairment: adjust dose based on kidney function.
  • Elderly patients: monitor for excessive sedation and falls.
  • History of psychiatric disorders: use with caution due to risk of hallucinations or mood changes.
  • Concomitant MAO‑inhibitors: avoid concurrent use to prevent hypertensive reactions.
  • Pregnancy and breastfeeding: safety not established; weigh potential benefits against risks.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Pramipexole may interact with several medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • MAO‑inhibitors (e.g., phenelzine): risk of hypertensive crisis.
  • Antipsychotics that block dopamine receptors: may diminish pramipexole’s effect.
  • Strong CYP2D6 inhibitors (e.g., quinidine): can raise pramipexole plasma levels.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: additive blood‑pressure‑lowering effect.
  • Alcohol: may enhance sedation and dizziness.
  • Other dopamine agonists: increase likelihood of impulse‑control problems.

Frequently Asked Questions

Nervius contains pramipexole, a dopamine agonist indicated for the treatment of Parkinson's disease to improve motor symptoms and for Restless Legs Syndrome to reduce the urge to move the legs and improve sleep quality.

Pramipexole works by selectively activating dopamine D2 and D3 receptors in the brain, which enhances dopaminergic neurotransmission. This action helps restore the balance of motor pathways that are deficient in Parkinson's disease and alleviates sensory discomfort in Restless Legs Syndrome.

The appropriate dose of Nervius is determined individually by a qualified prescriber based on the patient’s condition, response, and tolerability. Dosage adjustments may be required for renal function, age, or concomitant medications, and should always follow the prescribing information.

Safety data for pramipexole in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and a healthcare professional should be consulted.

To order Nervius, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Nervius (pramipexole) is a non‑ergot dopamine agonist with high selectivity for D2/D3 receptors, offering once‑daily dosing for many patients. Compared with other agents such as ropinirole or bromocriptine, pramipexole often shows a lower incidence of nausea but may have a higher propensity for impulse‑control disorders, requiring individualized assessment.

Nervius should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date printed on the label.

Nervius is taken orally, usually with or without food, as directed by the prescriber. Tablets should be swallowed whole with a glass of water and not chewed or crushed, unless the prescribing information specifically allows an alternative method.

Serious risks associated with Nervius include impulse‑control disorders (such as compulsive gambling or shopping), sudden onset of sleep, orthostatic hypotension, severe hallucinations, and worsening depression or suicidal thoughts. Patients should seek immediate medical attention if any of these symptoms occur.

Nervius is contraindicated in patients with known hypersensitivity to pramipexole or any of its excipients. It should be used with caution, or avoided, in individuals with severe renal impairment, uncontrolled psychiatric illness, or those currently taking monoamine oxidase inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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