Product image of Nesyrgy (Amlodipine Besilate, Nebivolol Hydrochloride) supplied by GNH India

Nesyrgy

Active Ingredient:
Amlodipine Besilate, Nebivolol Hydrochloride
Origin:
EU

Nesyrgy (Amlodipine Besilate, Nebivolol Hydrochloride)

Amlodipine besilate and nebivolol hydrochloride, the active ingredients in Nesyrgy, are a calcium channel blocker and a beta‑blocker presented as an oral tablet for oral use. They are indicated for the treatment of hypertension in adult patients.
GNH India supplies Nesyrgy as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

  • Nesyrgy combines a calcium‑channel blocker and a beta‑blocker to manage hypertension.
  • Hypertension (essential): lowers both systolic and diastolic blood pressure.
  • Isolated systolic hypertension: improves arterial compliance and reduces pulse pressure.
  • High cardiovascular‑risk hypertension: adds heart‑rate control to reduce overall cardiovascular strain.

How It Works

  • Amlodipine besilate blocks L‑type calcium channels in vascular smooth muscle, preventing calcium influx and causing vasodilation. Nebivolol hydrochloride selectively antagonises β1‑adrenergic receptors, decreasing heart rate and cardiac output, while also stimulating endothelial nitric‑oxide release for additional vasodilation, together producing a synergistic antihypertensive effect.

Side Effects

Common Side Effects

  • Headache: mild to moderate intensity.
  • Peripheral edema: swelling of the ankles or feet.
  • Dizziness or light‑headedness, especially after standing.
  • Flushing: transient warmth and redness of the skin.
  • Fatigue or tiredness.
  • Palpitations: sensation of irregular heartbeat.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Angioedema: swelling of face, lips, tongue, or throat.
  • Hepatic injury: abnormal liver function tests.
  • Bronchospasm: difficulty breathing, particularly in patients with asthma.
  • Cardiac conduction disorders: heart block or severe bradycardia.
  • Anaphylactic reactions: sudden severe allergic response.

Precautions & Warnings

  • Before initiating therapy, clinicians should assess cardiovascular status and monitor blood pressure regularly.
  • Monitor blood pressure: adjust dose if target not achieved.
  • Assess cardiac function: especially in patients with heart failure.
  • Caution in hepatic impairment: dose may need adjustment.
  • Avoid abrupt discontinuation: taper to prevent rebound hypertension.
  • Use with caution in elderly patients: increased sensitivity to hypotensive effects.
  • Store at ambient temperature: keep in original container, protect from moisture.

Avoid Interactions

Nesyrgy may interact with several medicines that affect blood pressure or drug metabolism.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase amlodipine levels.
  • Concomitant use with other antihypertensives (e.g., ACE inhibitors, diuretics): additive hypotensive effect.
  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil): risk of severe hypotension.

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may raise nebivolol concentrations.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): can blunt antihypertensive response.
  • Other calcium‑channel blockers (e.g., verapamil, diltiazem): may increase amlodipine exposure.
  • Beta‑agonists (e.g., albuterol): may reduce nebivolol efficacy.
  • Diuretics: monitor electrolytes and renal function.

Frequently Asked Questions

Nesyrgy is an oral antihypertensive medication that combines amlodipine besilate, a calcium‑channel blocker, with nebivolol hydrochloride, a selective β1‑blocker. The combination is prescribed to lower elevated blood pressure in adult patients, helping to reduce the risk of cardiovascular complications associated with hypertension.

Amlodipine besilate blocks L‑type calcium channels in the smooth muscle of blood vessels, preventing calcium entry that would cause contraction. This inhibition leads to vasodilation, decreasing peripheral vascular resistance and lowering systolic and diastolic blood pressure.

The appropriate dose of Nesyrgy is determined by the prescribing healthcare professional based on the individual’s blood‑pressure profile, age, renal and hepatic function, and concomitant medications. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of Nesyrgy in pregnancy or while breastfeeding has not been fully established. Healthcare providers should weigh the potential benefits against possible risks before prescribing it to pregnant or lactating women, and alternative therapies may be considered.

To order Nesyrgy, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nesyrgy offers a dual mechanism—vasodilation from amlodipine and heart‑rate reduction plus nitric‑oxide‑mediated vasodilation from nebivolol. Compared with monotherapy agents, this combination can achieve better blood‑pressure control with potentially fewer tablets, but individual response and tolerability vary, so clinicians choose therapy based on patient‑specific factors.

Nesyrgy tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and avoid storing in bathrooms or other humid environments.

Nesyrgy is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush, chew, or split the tablet unless specifically instructed by a healthcare professional.

Serious risks include severe hypotension, angioedema, hepatic injury, bronchospasm in susceptible individuals, and cardiac conduction disturbances such as heart block or marked bradycardia. Patients should seek immediate medical attention if they experience symptoms like sudden dizziness, swelling of the face or throat, or irregular heartbeat.

Nesyrgy is contraindicated in patients with known hypersensitivity to amlodipine, nebivolol, or any excipients, as well as in individuals with severe aortic stenosis, cardiogenic shock, or uncontrolled heart failure. Caution is also advised for patients with significant liver disease or those taking interacting medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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