Product image of Nesyrgy (Amlodipine Besilate, Nebivolol Hydrochloride) supplied by GNH India

Nesyrgy

Active Ingredient:
Amlodipine Besilate, Nebivolol Hydrochloride
Origin:
EU

Nesyrgy (Amlodipine Besilate, Nebivolol Hydrochloride)

Amlodipine besilate and nebivolol hydrochloride, the active ingredients in Nesyrgy, are a calcium‑channel blocker and a β1‑selective beta‑blocker presented as an oral tablet for systemic use. They treat hypertension in adult patients by lowering blood pressure through vascular relaxation and reduced cardiac output.

GNH India supplies Nesyrgy as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for export to multiple regions, ensuring reliable supply chains and timely delivery.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

  • Nesyrgy combines a calcium‑channel blocker and a β1‑selective beta‑blocker to manage hypertension and related blood‑pressure disorders.
  • Hypertension: reduces systolic and diastolic blood pressure, lowering cardiovascular risk.
  • Isolated systolic hypertension: improves systolic pressure control in older adults.
  • Diastolic hypertension: decreases diastolic pressure to target levels.

How It Works

  • Amlodipine besilate inhibits L‑type calcium channels in vascular smooth muscle, causing vasodilation and reduced peripheral resistance. Nebivolol hydrochloride selectively blocks β1‑adrenergic receptors, decreasing heart rate and cardiac output, while also stimulating endothelial nitric‑oxide release for additional vasodilation. The combined actions result in a synergistic reduction of arterial pressure.

Side Effects

Adverse reactions reported with Nesyrgy are categorized as common and serious or rare.

Common Side Effects

  • Headache
  • Peripheral edema
  • Flushing
  • Dizziness

Serious or Rare Side Effects

  • Severe hypotension
  • Bradycardia
  • Angioedema

Precautions & Warnings

  • Before prescribing Nesyrgy, clinicians should consider several safety measures.
  • Monitor blood pressure regularly: adjust therapy as needed.
  • Assess hepatic function before initiating therapy: consider dose adjustment in liver impairment.
  • Evaluate for heart failure: use cautiously in decompensated patients.
  • Use with caution in elderly: increased sensitivity to blood‑pressure lowering effects.
  • Avoid abrupt discontinuation: may cause rebound hypertension.
  • Store at room temperature: keep in original container, protect from moisture.

Avoid Interactions

Nesyrgy may interact with other medicines; some combinations should be avoided while others require monitoring.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase amlodipine exposure.
  • Concomitant use with other antihypertensives (e.g., ACE inhibitors, diuretics): additive hypotensive effect.
  • Non‑dihydropyridine calcium‑channel blockers (e.g., verapamil): risk of excessive cardiac depression.

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors (e.g., fluoxetine): may raise nebivolol levels.
  • NSAIDs or alcohol: can attenuate blood‑pressure reduction or increase dizziness.

Frequently Asked Questions

Nesyrgy is prescribed to lower elevated blood pressure in adults diagnosed with hypertension. By combining two complementary mechanisms, it helps achieve target blood‑pressure levels and reduces the risk of cardiovascular complications associated with sustained hypertension.

Amlodipine besilate blocks L‑type calcium channels in the smooth muscle of arteries, preventing calcium influx that is necessary for contraction. This results in relaxation of the vascular wall, decreased peripheral resistance, and ultimately lower arterial pressure.

The dose of Nesyrgy is individualized by the prescribing clinician based on the patient’s blood‑pressure readings, overall health status, and response to therapy. The prescriber determines the appropriate strength and dosing schedule for each patient.

Safety data for Nesyrgy during pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To request Nesyrgy, submit an enquiry on the product page at gnhindia.com with the desired quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Nesyrgy offers a dual‑action approach, combining a calcium‑channel blocker and a β1‑selective blocker in a single tablet. This can simplify regimens compared with taking separate agents and may provide more consistent blood‑pressure control than monotherapy, while maintaining a safety profile comparable to other combination products.

Store Nesyrgy at room temperature, below 25 °C, in the original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiration date printed on the label.

Nesyrgy is taken orally, usually once daily, with a glass of water. It can be taken with or without food, but patients should follow the specific instructions provided by their healthcare provider.

Patients should be alert for signs of severe hypotension such as dizziness, fainting, or rapid heartbeat, as well as bradycardia (unusually slow heart rate) and any swelling of the face, lips, tongue, or throat that could indicate angioedema. Prompt medical attention is required if these symptoms occur.

Nesyrgy is contraindicated in individuals with severe hypotension, cardiogenic shock, second‑ or third‑degree atrioventricular block, uncontrolled heart failure, or known hypersensitivity to either amlodipine, nebivolol, or any excipients in the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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