Product image of Nesyrgy (Amlodipine Besilate, Nebivolol Hydrochloride) supplied by GNH India

Nesyrgy

Active Ingredient:
Amlodipine Besilate, Nebivolol Hydrochloride
Origin:
EU

Nesyrgy (Amlodipine Besilate, Nebivolol Hydrochloride)

Amlodipine besilate / nebivolol hydrochloride, the active ingredient in Nesyrgy, is a calcium channel blocker / beta‑blocker presented as a tablet for oral use. It is indicated for the treatment of hypertension in adult patients.
GNH India supplies Nesyrgy as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

  • Nesyrgy, a combination antihypertensive, is used to manage elevated blood pressure.
  • Hypertension: reduces systolic and diastolic blood pressure and helps achieve target blood pressure goals.

How It Works

  • Amlodipine besilate blocks L‑type calcium channels in vascular smooth muscle, causing vasodilation and reduced peripheral resistance. Nebivolol hydrochloride selectively antagonizes β1‑adrenergic receptors, lowering heart rate and cardiac output, while also stimulating endothelial nitric‑oxide release for additional vasodilation. The combined actions produce additive blood‑pressure‑lowering effects.

Side Effects

Common Side Effects

  • Headache: mild to moderate intensity.
  • Peripheral edema: swelling of ankles or feet.
  • Flushing: transient warmth and redness.
  • Dizziness or light‑headedness.
  • Fatigue: general tiredness.
  • Nasal congestion: mild blockage.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure.
  • Bradycardia: abnormally slow heart rate.
  • Hepatic injury: elevated liver enzymes or jaundice.
  • Allergic reaction: rash, itching, or swelling.
  • Angioedema: rapid swelling of face, lips, or throat.
  • Cardiac conduction abnormalities: heart block or arrhythmia.

Precautions & Warnings

  • Before initiating therapy, consider the following precautions.
  • Monitor blood pressure: ensure adequate control and avoid excessive reduction.
  • Assess cardiac function: evaluate heart rate and rhythm, especially in patients with conduction disorders.
  • Review concomitant medications: watch for additive hypotensive effects.
  • Use caution in hepatic impairment: dose adjustment may be required.
  • Avoid abrupt discontinuation: taper gradually to prevent rebound hypertension.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nesyrgy may interact with several medicines; monitoring is advised.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): increase amlodipine exposure.
  • CYP2D6 inhibitors (e.g., paroxetine): raise nebivolol plasma levels.
  • Other antihypertensives (e.g., ACE inhibitors, ARBs): additive blood‑pressure lowering effect.

Moderate Interactions (Monitor Closely):\n- Non‑dihydropyridine calcium‑channel blockers (e.g., verapamil): may enhance bradycardia.

  • Additional beta‑blockers: risk of excessive heart‑rate reduction.
  • Diuretics: may potentiate electrolyte disturbances.
  • NSAIDs: can blunt antihypertensive response.
  • Alcohol: may increase dizziness and hypotension.

Frequently Asked Questions

Nesyrgy is a prescription medication that combines amlodipine besilate and nebivolol hydrochloride to treat hypertension. By lowering both peripheral vascular resistance and cardiac output, it helps patients achieve and maintain target blood‑pressure levels.

Amlodipine besilate is a dihydropyridine calcium‑channel blocker that relaxes vascular smooth muscle. This vasodilation reduces peripheral resistance, contributing to a decrease in systolic and diastolic blood pressure.

The appropriate dose of Nesyrgy is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and any concomitant medications. Dosage adjustments are individualized and should follow the prescriber’s instructions.

Safety data for Nesyrgy in pregnancy and lactation are limited. Clinicians should weigh the potential benefits against possible risks and consider alternative therapies when treating pregnant or nursing individuals.

To request Nesyrgy, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nesyrgy combines a calcium‑channel blocker and a beta‑blocker in a single tablet, offering dual mechanisms that may provide more consistent blood‑pressure control compared with monotherapy. It can be an alternative for patients who need both vasodilation and heart‑rate reduction without taking separate pills.

Store Nesyrgy at room temperature, below 25 °C, in the original packaging. Keep the tablets away from moisture, heat, and direct sunlight to maintain product stability.

Nesyrgy is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water and not chewed or crushed.

Serious risks include severe hypotension, bradycardia, hepatic injury, allergic reactions such as angioedema, and cardiac conduction abnormalities. Patients should seek immediate medical attention if they experience symptoms like fainting, rapid weight gain, jaundice, or swelling of the face or throat.

Nesyrgy is contraindicated in patients with known hypersensitivity to amlodipine, nebivolol, or any excipients, as well as in individuals with severe aortic stenosis, uncontrolled heart failure, or significant bradycardia. Clinicians should evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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