Product image of Nesyrgy (Amlodipine Besilate, Nebivolol Hydrochloride) supplied by GNH India

Nesyrgy

Active Ingredient:
Amlodipine Besilate, Nebivolol Hydrochloride
Origin:
EU

Nesyrgy (Amlodipine Besilate, Nebivolol Hydrochloride)

Amlodipine besilate, the active ingredient in Nesyrgy, is a calcium‑channel blocker presented as an oral tablet for oral use. It is combined with nebivolol hydrochloride, a selective β1‑blocker, to lower elevated blood pressure in adult patients with hypertension. The combination is approved in the European Union and is indicated for patients who require dual therapy to achieve target blood pressure.
GNH India supplies Nesyrgy as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, and adheres to stringent quality standards for export.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

  • Nesyrgy, containing amlodipine besilate and nebivolol hydrochloride, is used in the management of hypertension, a cardiovascular condition characterized by elevated arterial pressure.
  • Hypertension: lowers systolic and diastolic blood pressure to target levels.
  • Essential hypertension: provides combined calcium‑channel blocker and β‑blocker therapy for patients uncontrolled on monotherapy.
  • Stage 2 hypertension: offers dual mechanism to achieve guideline‑recommended blood pressure goals.

How It Works

  • Amlodipine besilate blocks L‑type calcium channels in vascular smooth muscle, causing vasodilation and reduced peripheral resistance. Nebivolol hydrochloride selectively antagonizes β1‑adrenergic receptors, decreasing heart rate and cardiac output, while also stimulating endothelial nitric‑oxide release, further promoting vasodilation. The combined actions result in additive blood‑pressure‑lowering effects.

Side Effects

Common Side Effects

  • Headache: mild to moderate intensity.
  • Peripheral edema: swelling of ankles or lower legs.
  • Flushing: transient warmth and redness.
  • Dizziness or light‑headedness, especially after standing.
  • Fatigue: general tiredness.
  • Palpitations: awareness of heartbeat.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Bradycardia: abnormally slow heart rate.
  • Atrioventricular block: impaired electrical conduction.
  • Hepatic injury: signs of liver dysfunction.
  • Allergic reactions: rash, itching, or hives.
  • Angioedema: swelling of face, lips, tongue, or throat.

Precautions & Warnings

  • Before initiating therapy, clinicians should consider patient‑specific factors and monitor for adverse events.
  • Monitor blood pressure: ensure adequate control without excessive lowering.
  • Assess cardiac function: evaluate for bradycardia or conduction abnormalities.
  • Review concomitant antihypertensives: adjust doses to avoid additive hypotension.
  • Caution in hepatic impairment: dose may need adjustment.
  • Avoid abrupt discontinuation: taper to prevent rebound hypertension.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nesyrgy may interact with several medicines; careful review is essential.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): increase plasma levels.
  • Other antihypertensives (e.g., ACE inhibitors, diuretics): additive blood‑pressure reduction.
  • Non‑dihydropyridine calcium‑channel blockers (e.g., verapamil): risk of severe bradycardia.
  • Beta‑blockers (e.g., propranolol): excessive β‑blockade.
  • Grapefruit juice: may raise amlodipine concentrations.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance electrolyte disturbances.
  • NSAIDs: can blunt antihypertensive effect.
  • Antidiabetic agents: blood‑glucose control may change, requiring monitoring.

Frequently Asked Questions

Nesyrgy is a prescription medication that combines amlodipine besilate and nebivolol hydrochloride to treat hypertension. The dual‑action formulation helps lower elevated blood pressure in adults by providing both vasodilation and reduced cardiac output.

Amlodipine besilate blocks L‑type calcium channels in the smooth muscle of blood vessels, leading to relaxation of the vessels and a decrease in peripheral resistance. This vasodilatory effect contributes to lowering systolic and diastolic blood pressure.

The appropriate dose of Nesyrgy is determined by the prescribing healthcare professional based on the patient’s clinical condition, response to therapy, and any concomitant medications. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of Nesyrgy in pregnancy or while breastfeeding has not been established. Healthcare providers should weigh the potential benefits against possible risks and consider alternative treatments if appropriate for pregnant or nursing individuals.

To request Nesyrgy, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nesyrgy offers a fixed‑dose combination of a calcium‑channel blocker and a β1‑selective blocker, providing two complementary mechanisms in a single tablet. This can simplify regimens compared with taking separate agents and may improve adherence versus monotherapy or other combination products that use different drug classes.

Nesyrgy tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the container tightly closed and out of reach of children.

Nesyrgy is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush, chew, or split the tablet unless specifically instructed.

Serious risks include severe hypotension, marked bradycardia, atrioventricular block, liver injury, and allergic reactions such as angioedema. Patients should seek immediate medical attention if they experience symptoms like fainting, rapid heartbeat, yellowing of the skin or eyes, or swelling of the face and throat.

Nesyrgy is contraindicated in patients with known hypersensitivity to amlodipine, nebivolol, or any component of the formulation. It should also be avoided in individuals with severe aortic stenosis, uncontrolled heart failure, or certain cardiac conduction disorders unless specifically approved by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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