Nettacin Viscoso (Netilmicin Sulfate)

• Netilmicin sulfate is employed to manage bacterial infections of the eye and related ocular tissues.
• Conjunctivitis: reduces bacterial load and accelerates resolution of acute bacterial conjunctivitis.
• Keratitis: eradicates causative organisms in bacterial keratitis and supports corneal healing.
• Blepharitis: diminishes bacterial colonisation on eyelid margins, improving symptoms.
• Post‑operative prophylaxis: prevents postoperative ocular infections after cataract or refractive surgery.

• Netilmicin sulfate binds to the 30S subunit of bacterial ribosomes, causing misreading of mRNA and inhibition of protein synthesis. This bactericidal action leads to rapid cell death of susceptible Gram‑negative and some Gram‑positive ocular pathogens, thereby controlling infection at the site of application.

Adverse reactions are generally limited to the treated eye, but monitoring is advised.

Common Side Effects

• Ocular irritation or stinging on instillation.
• Burning sensation after application.
• Redness of the conjunctiva.
• Increased tearing.

Serious or Rare Side Effects

• Allergic reaction including anaphylaxis.
• Corneal ulceration or epithelial defect.
• Severe eye pain indicating possible toxicity.

Before using Nettacin Viscoso, consider the following safety measures.

• Assess bacterial susceptibility: confirm that the pathogen is likely responsive to aminoglycosides.
• Hypersensitivity: avoid in patients with known allergy to netilmicin or other aminoglycosides.
• Renal function: monitor if systemic absorption is suspected, especially in compromised patients.
• Contact lens wearers: advise removal of lenses before and after instillation.
• Ocular surface integrity: do not use on severely damaged corneas without specialist advice.
• Store at room temperature: keep in original container, protect from moisture and light.

Netilmicin may interact with other ophthalmic or systemic agents; awareness helps prevent reduced efficacy or increased toxicity.

Major Interactions (Avoid)

• Concurrent use with other aminoglycoside eye drops (e.g., gentamicin) may increase local toxicity.
• Simultaneous administration of multiple topical antibiotics can lead to antagonistic effects.

Moderate Interactions (Monitor Closely)

• Co‑administration with topical corticosteroids may mask infection signs.
• Use with preservative‑containing contact lens solutions may irritate the ocular surface.
• Systemic aminoglycosides given concurrently could raise systemic exposure.