Neuair Airmaster (Fluticasone Propionate, Salmeterol)

Neuair Airmaster is used as maintenance therapy in the respiratory disease pathways of asthma and chronic obstructive pulmonary disease.

• Asthma: improves long‑term control, reduces symptoms and frequency of exacerbations.
• Chronic obstructive pulmonary disease (COPD): enhances airflow, decreases dyspnoea and lowers risk of flare‑ups.
• Severe persistent asthma: provides sustained anti‑inflammatory and bronchodilator effects for patients requiring high‑dose therapy.

• Fluticasone propionate binds to glucocorticoid receptors in airway cells, modulating gene transcription to suppress inflammatory cytokine production and reduce airway edema. Salmeterol selectively stimulates β2‑adrenergic receptors on bronchial smooth muscle, activating adenylate cyclase and increasing cyclic AMP, which leads to prolonged bronchodilation. This dual mechanism supports improved lung function and symptom control over the dosing interval.

The most frequently reported adverse reactions with Neuair Airmaster involve the respiratory tract and systemic effects typical of inhaled corticosteroids and long‑acting β2‑agonists.

Common Side Effects

• Oral thrush (candidiasis): localized fungal infection in the mouth.
• Hoarseness or voice change: irritation of the laryngeal mucosa.
• Cough or throat irritation: transient discomfort after inhalation.
• Headache: mild to moderate intensity.
• Nasal congestion: nasal mucosal swelling.

Serious or Rare Side Effects

• Paradoxical bronchospasm: sudden worsening of breathing.
• Adrenal suppression: reduced cortisol production with prolonged high‑dose use.
• Severe allergic reaction (anaphylaxis): rare but potentially life‑threatening.
• Pneumonia: especially in COPD patients.
• Osteoporosis: decreased bone mineral density with long‑term therapy.

Before prescribing Neuair Airmaster, clinicians should consider several precautionary measures to ensure safe use.

• Assess infection risk: avoid use during active respiratory infections unless benefits outweigh risks.
• Monitor for oral candidiasis: advise rinsing mouth after each inhalation.
• Evaluate bone health: consider calcium and vitamin D supplementation for long‑term therapy.
• Use lowest effective dose: titrate to maintain symptom control while minimizing exposure.
• Caution in cardiovascular disease: monitor heart rate and blood pressure due to β2‑agonist effects.
• Store below 30°C: keep in original packaging, protect from moisture and heat.

Neuair Airmaster may interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

• Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): may increase systemic exposure to fluticasone.
• Monoamine oxidase inhibitors (MAOIs): can potentiate sympathomimetic effects of salmeterol, raising risk of hypertension.

Moderate Interactions (Monitor Closely)

• Diuretics and β‑blockers: may blunt bronchodilator response, requiring dose adjustment.
• Theophylline: concurrent use may increase risk of tachyarrhythmias.
• Anticholinergic agents: additive anticholinergic side effects such as dry mouth.
• Live attenuated vaccines: consider timing due to immunosuppressive potential of inhaled steroids.