Product image of Neudolox (Pregabalin) supplied by GNH India

Neudolox

Active Ingredient:
Pregabalin
Origin:
EU

Neudolox (Pregabalin)

Pregabalin, the active ingredient in Neudolox, is a gabapentinoid presented as an oral tablet for oral use. It is indicated for neuropathic pain, partial seizures, generalized anxiety disorder, and fibromyalgia in adult patients. Its mechanism involves binding to the α2δ subunit of voltage‑gated calcium channels, reducing excitatory neurotransmitter release.

GNH India supplies Neudolox as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with manufacturing adhering to EU Good Manufacturing Practice and distribution to multiple regions.

Manufacturer / TM Owner

Exeltis Slovakia

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Indications & Clinical Uses

Pregabalin is used in several neurological and pain‑related conditions, acting on the central nervous system to modulate abnormal neuronal activity.

  • Neuropathic pain: Reduces pain intensity and improves functional outcomes in conditions such as diabetic peripheral neuropathy and post‑herpetic neuralgia.
  • Partial seizures (epilepsy): Decreases seizure frequency as adjunctive therapy in adults with focal onset seizures.
  • Generalized anxiety disorder: Alleviates anxiety symptoms and improves overall anxiety rating scales.
  • Fibromyalgia: Mitigates widespread musculoskeletal pain and associated fatigue in fibromyalgia patients.

How It Works

  • Pregabalin binds selectively to the α2δ auxiliary subunit of voltage‑gated calcium channels in the central nervous system. This binding reduces calcium influx into presynaptic neurons, thereby decreasing the release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P. The resulting modulation of neuronal excitability underlies its anticonvulsant, analgesic, and anxiolytic effects.

Side Effects

Pregabalin may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Dizziness
  • Somnolence
  • Peripheral edema
  • Weight gain
  • Blurred vision
  • Dry mouth

Serious or Rare Side Effects

  • Angioedema or severe allergic reactions
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Suicidal thoughts or behavior
  • Respiratory depression, especially with CNS depressants
  • Hematologic abnormalities such as neutropenia
  • Severe skin rash or bullous eruptions

Precautions & Warnings

When prescribing Pregabalin, clinicians should observe several safety considerations.

  • Assess renal function: Adjust dose in patients with impaired kidney function.
  • Monitor for suicidal ideation: Observe mood changes, especially during treatment initiation.
  • Avoid abrupt discontinuation: Taper the dose to reduce withdrawal symptoms.
  • Use caution in elderly: Increased sensitivity to CNS effects may occur.
  • Review concomitant CNS depressants: Combined use can enhance sedation and respiratory depression.
  • Store at room temperature: Keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Pregabalin can interact with other medicines, requiring attention to potential additive effects.

Major Interactions (Avoid)

  • Opioids or strong CNS depressants: Combined use may cause profound sedation or respiratory depression.
  • Alcohol: Increases risk of dizziness, somnolence, and impaired coordination.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: May enhance hypotensive effect, requiring blood pressure monitoring.
  • Diuretics: Can increase risk of peripheral edema.
  • Certain antiepileptic drugs (e.g., carbamazepine): May alter pregabalin plasma levels.

Frequently Asked Questions

Neudolox, containing pregabalin, is prescribed for neuropathic pain such as diabetic peripheral neuropathy, as adjunct therapy for partial (focal) seizures, for generalized anxiety disorder, and to relieve pain and fatigue associated with fibromyalgia. These indications are supported by clinical guidelines and regulatory approvals in many jurisdictions.

Pregabalin binds to the α2δ subunit of voltage‑gated calcium channels in the central nervous system. This reduces calcium entry into nerve terminals, decreasing the release of excitatory neurotransmitters like glutamate, norepinephrine, and substance P, which helps to dampen abnormal neuronal firing responsible for pain, seizures, and anxiety.

The appropriate dose of Neudolox is individualized by the prescribing clinician based on the specific indication, patient age, renal function, and response to therapy. Dosage titration follows established clinical guidelines, and patients should follow the prescriber’s instructions without self‑adjusting the amount.

Safety data for pregabalin in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any potential risk to the fetus. Women who are breastfeeding should discuss alternatives with their healthcare provider, as pregabalin may be excreted in breast milk.

To request Neudolox, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and assistance with import documentation.

The primary alternative to pregabalin is gabapentin, another gabapentinoid. Both share a similar mechanism, but pregabalin generally has higher bioavailability, more predictable pharmacokinetics, and may achieve therapeutic effect at lower doses. Choice between them depends on individual patient response, tolerability, and prescriber preference.

Neudolox should be stored at room temperature, below 25 °C (77 °F). Keep the tablets in the original blister pack or container, protect them from moisture, excessive heat, and direct sunlight. Do not store in the bathroom or near a kitchen sink where humidity is high.

Neudolox is taken orally, usually with or without food, as directed by the prescriber. Tablets should be swallowed whole with a glass of water. Patients should not crush, chew, or split the tablets unless specifically instructed, to maintain consistent absorption.

Serious risks include the development of suicidal thoughts or behavior, severe allergic reactions such as angioedema, respiratory depression when combined with other CNS depressants, and rare skin conditions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they notice rash, swelling of the face or throat, or changes in mood.

Neudolox is contraindicated in patients with known hypersensitivity to pregabalin or any of the tablet’s excipients. Caution is advised for individuals with severe renal impairment, uncontrolled psychiatric illness, or those taking multiple CNS depressants. Pregnant or nursing women should only use it when clearly needed and after consulting a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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