Product image of Neuramin (Thiamine Hydrochloride) supplied by GNH India

Neuramin

Active Ingredient:
Thiamine Hydrochloride
Origin:
EU

Neuramin (Thiamine Hydrochloride)

Thiamine Hydrochloride, the active ingredient in Neuramin, is a Vitamin B1 (thiamine) presented as a sterile solution for intramuscular and intravenous use. It is employed to treat thiamine deficiency‑related conditions such as beriberi and Wernicke’s encephalopathy, particularly in patients with chronic alcoholism or malnutrition.

GNH India supplies Neuramin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orion Corporation

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Indications & Clinical Uses

Neuramin is a vitamin B1 preparation used to correct thiamine deficiency and its neurological and cardiovascular complications.

  • Beriberi: restores thiamine stores, relieving peripheral neuropathy, edema and cardiac dysfunction.
  • Wernicke's encephalopathy: rapidly reverses confusion, ophthalmoplegia and ataxia in at‑risk patients.
  • Alcohol‑related malnutrition: prevents deficiency‑related neuro‑cognitive decline in chronic alcohol users.
  • General prophylaxis: maintains adequate thiamine levels during prolonged fasting or parenteral nutrition.

How It Works

  • Thiamine Hydrochloride acts as an essential cofactor for several enzymes involved in carbohydrate metabolism, including pyruvate dehydrogenase, α‑ketoglutarate dehydrogenase and transketolase. By facilitating the decarboxylation of pyruvate and the pentose‑phosphate pathway, it supports ATP generation and neuronal energy metabolism, thereby correcting the metabolic disturbances caused by thiamine deficiency.

Side Effects

Thiamine Hydrochloride is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Injection site pain or erythema.
  • Nausea or mild gastrointestinal upset.
  • Headache.
  • Dizziness.
  • Transient flushing or warmth.
  • Mild hypotension.

Serious or Rare Side Effects

  • Anaphylactic reaction.
  • Severe hypotension or shock.
  • Acute allergic dermatitis.
  • Angioedema.
  • Respiratory distress.
  • Cardiovascular collapse.

Precautions & Warnings

Thiamine administration requires careful clinical assessment and monitoring.

  • Assess thiamine status: evaluate risk factors such as alcoholism, malnutrition or chronic illness.
  • Monitor for allergic reactions: observe for rash, itching or respiratory symptoms during and after injection.
  • Adjust in renal impairment: consider reduced clearance in severe kidney disease.
  • Use with caution in pregnancy or lactation: benefits should outweigh potential risks.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Thiamine may interact with other agents that affect its absorption, metabolism or clinical effect.

Major Interactions (Avoid)

  • High‑dose furosemide: can increase urinary thiamine loss, worsening deficiency.
  • Intravenous glucose without thiamine in at‑risk patients: may precipitate Wernicke’s encephalopathy.
  • Chronic alcohol consumption: impairs thiamine utilization, necessitating higher supplementation.

Moderate Interactions (Monitor Closely)

  • Anticonvulsants (phenytoin, phenobarbital): may accelerate thiamine metabolism.
  • Metformin: potential alteration of gastrointestinal absorption.
  • Certain chemotherapeutic agents: may increase thiamine requirements during treatment.

Frequently Asked Questions

Neuramin contains thiamine hydrochloride, a vitamin B1 formulation used to treat and prevent thiamine deficiency. It is indicated for conditions such as beriberi, Wernicke’s encephalopathy, and deficiency states associated with chronic alcoholism, malnutrition, or prolonged fasting.

Thiamine hydrochloride serves as a cofactor for enzymes that drive carbohydrate metabolism, including pyruvate dehydrogenase and transketolase. By supporting these pathways, it enhances ATP production and maintains neuronal function, correcting the metabolic deficits caused by low thiamine levels.

The appropriate dose of Neuramin is determined by the prescribing healthcare professional based on the patient’s clinical condition, severity of deficiency, and route of administration. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for thiamine hydrochloride in pregnancy and lactation are limited. It is generally considered low risk, but use should only occur when the potential benefit justifies any possible risk. The prescriber should evaluate each case individually.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Neuramin is a sterile injectable form of thiamine hydrochloride, offering rapid systemic availability compared with oral tablets or capsules. This makes it preferable for acute correction of deficiency, especially in patients unable to absorb oral thiamine or who require immediate neurological support.

Neuramin should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight and extreme temperature fluctuations to maintain potency and sterility.

Neuramin is administered by a qualified healthcare professional via intramuscular or intravenous injection. The route, infusion rate and volume are selected according to the patient’s condition and the prescriber’s orders.

Serious adverse reactions, although rare, include anaphylaxis, severe hypotension, angioedema and respiratory distress. Immediate medical attention is required if any signs of a severe allergic response occur during or after administration.

Neuramin is contraindicated in individuals with a known hypersensitivity to thiamine hydrochloride or any excipients in the formulation. Patients with a history of severe allergic reactions to injectable vitamins should avoid its use unless under strict medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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