Product image of Neurex (Citicoline Sodium) supplied by GNH India

Neurex

Active Ingredient:
Citicoline Sodium
Origin:
EU

Neurex (Citicoline Sodium)

Citicoline sodium, the active ingredient in Neurex, is a nootropic / neuroprotective agent presented as an injection for intramuscular and intravenous use. It is used in the management of ischemic stroke, traumatic brain injury, and cognitive impairment in adult patients.

GNH India supplies Neurex as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Euro-Pharma S.R.L.

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Indications & Clinical Uses

  • Neurex (citicoline sodium) is employed in conditions affecting cerebral blood flow and neuronal integrity.
  • Ischemic stroke: supports neuronal membrane repair and may improve functional recovery.
  • Traumatic brain injury: enhances neuroprotection and aids restoration of cognitive functions.
  • Cognitive impairment: increases acetylcholine availability to help mitigate deficits in attention and memory.

How It Works

  • Citicoline sodium provides choline and cytidine precursors that boost phosphatidylcholine synthesis, facilitating neuronal membrane repair. The increased choline pool enhances acetylcholine production, while cytidine contributes to neuronal RNA synthesis. These actions together support neuroprotection, improve synaptic transmission, and may aid recovery after cerebral injury.

Side Effects

Adverse reactions have been reported with citicoline sodium injections.

Common Side Effects

  • Injection site pain
  • Headache
  • Nausea
  • Dizziness

Serious or Rare Side Effects

  • Anaphylactic reaction
  • Severe hypotension
  • Seizure

Precautions & Warnings

  • Neurex should be used with clinical vigilance.
  • Assess renal function: adjust use in severe impairment.
  • Monitor neurological status: observe for changes during therapy.
  • Evaluate for hypersensitivity: discontinue if allergic signs appear.
  • Use caution with uncontrolled hypertension: blood pressure may fluctuate.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Citicoline sodium may interact with several drug classes.

Major Interactions (Avoid)

  • Anticoagulants: increased bleeding risk.
  • MAO inhibitors: potential amplification of neurochemical effects.
  • Other cholinergic agents: excess acetylcholine may occur.
  • Hypotensive agents: risk of severe blood pressure drop.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may raise renal impairment risk.
  • Antiepileptic drugs: could reduce citicoline efficacy.
  • Statins: possible additive hepatic load.

Frequently Asked Questions

Neurex contains citicoline sodium and is used as a neuroprotective and cognitive‑enhancing agent in adult patients with ischemic stroke, traumatic brain injury, or other forms of cognitive impairment where neuronal membrane repair and neurotransmitter support are desired.

Citicoline sodium supplies choline and cytidine, which are precursors for phosphatidylcholine synthesis and acetylcholine production. This promotes neuronal membrane stability, supports RNA synthesis, and enhances neurotransmission, contributing to neuroprotection and improved cognitive function after cerebral injury.

The appropriate dose of Neurex is determined by the prescribing clinician based on the patient’s condition, severity, and route of administration. Dosage regimens are individualized and should follow the prescriber’s instructions and local regulatory guidelines.

Safety data for citicoline sodium in pregnancy and lactation are limited. The product’s pregnancy category is unknown, so it should only be used if the potential benefit justifies any potential risk to the fetus or infant, and after consultation with a qualified healthcare professional.

To request Neurex, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Compared with other neuroprotective agents, citicoline sodium uniquely provides both choline and cytidine precursors, directly supporting membrane phospholipid synthesis and acetylcholine production. This dual mechanism distinguishes it from agents that act solely as antioxidants or excitatory blockers, offering a broader approach to neuronal recovery.

Neurex should be stored at 2‑8 °C, protected from light, and kept in its original packaging. Do not freeze or shake the vials. Before administration, allow the product to reach room temperature if required, and inspect for particulate matter or discoloration.

Neurex is supplied as a sterile injectable solution and may be given either intramuscularly or intravenously, depending on the clinical protocol. Administration should be performed by qualified healthcare personnel using aseptic technique and appropriate infusion or injection equipment.

The most serious risks include severe allergic reactions such as anaphylaxis, marked hypotension, and rare occurrences of seizures. Patients should be monitored closely for any signs of these events, and treatment should be discontinued immediately if they occur.

Neurex should be avoided in individuals with known hypersensitivity to citicoline sodium or any excipients in the formulation. Caution is also advised for patients with uncontrolled hypertension, severe renal impairment, or those taking medications that could cause dangerous additive hypotensive effects.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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