Product image of Neurobion Advance (Cyanocobalamin, Thiamine Nitrate, Pyridoxine Hydrochloride) supplied by GNH India

Neurobion Advance

Active Ingredient:
Cyanocobalamin, Thiamine Nitrate, Pyridoxine Hydrochloride
Origin:
EU

Neurobion Advance (Cyanocobalamin, Thiamine Nitrate, Pyridoxine Hydrochloride)

Cyanocobalamin, Thiamine nitrate, Pyridoxine hydrochloride, the active ingredient in Neurobion Advance, is a vitamin B complex supplement presented as an oral tablet for oral use. It helps address deficiencies of vitamins B12, B1 and B6 and supports nerve health and blood formation in adults and children.

GNH India supplies Neurobion Advance as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company ensures quality manufacturing according to EU standards and provides reliable distribution across multiple markets.

Manufacturer / TM Owner

P&g Health Germany Gmbh

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Indications & Clinical Uses

Neurobion Advance provides vitamin B1, B6 and B12 supplementation, addressing conditions linked to B‑vitamin deficiency.

  • Vitamin B12 deficiency: restores normal red blood cell formation and neurological function.
  • Vitamin B1 deficiency (beriberi): alleviates fatigue, weakness and cardiovascular disturbances.
  • Peripheral neuropathy associated with B‑vitamin deficiency: reduces nerve pain and improves sensory function.

How It Works

  • The three B‑vitamins act as essential co‑factors in enzymatic reactions. Cyanocobalamin (vitamin B12) participates in methylmalonyl‑CoA mutase and methionine synthase, supporting myelin synthesis and DNA replication. Thiamine nitrate (vitamin B1) is converted to thiamine pyrophosphate, a co‑enzyme for carbohydrate metabolism and neuronal energy production. Pyridoxine hydrochloride (vitamin B6) is converted to pyridoxal‑5′‑phosphate, a co‑factor in amino‑acid transamination, neurotransmitter synthesis and hemoglobin formation.

Side Effects

Oral administration of Neurobion Advance may be associated with a range of adverse reactions.

Common Side Effects

  • Nausea: mild stomach upset.
  • Headache: transient.
  • Skin rash: mild erythema.
  • Diarrhoea: loose stools.
  • Metallic taste: temporary sensation.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Stevens‑Johnson syndrome: rare severe skin reaction.
  • Hemolytic anemia: uncommon blood disorder.
  • Thrombocytopenia: low platelet count.
  • Severe hypersensitivity: including facial swelling or difficulty breathing.

Precautions & Warnings

When considering Neurobion Advance, several safety measures should be observed.

  • Pregnancy: use only if clearly needed and prescribed by a healthcare professional.
  • Breastfeeding: consult a physician before use.
  • Renal impairment: monitor vitamin B12 levels and adjust dosage if required.
  • Known hypersensitivity: avoid if allergic to any of the B‑vitamins.
  • Drug interactions: review concomitant medications for potential interactions.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Neurobion Advance can influence the activity of certain medicines, requiring attention to possible interactions.

Major Interactions (Avoid)

  • Methotrexate: high-dose vitamin B12 may reduce its efficacy; monitor closely.
  • Levodopa: excessive pyridoxine can diminish therapeutic effect; consider dose adjustment.

Moderate Interactions (Monitor Closely)

  • Antibiotics (tetracyclines, chloramphenicol): may interfere with vitamin absorption.
  • Anticonvulsants (phenytoin, phenobarbital): may increase vitamin B6 metabolism.
  • Oral contraceptives: may alter plasma levels of B‑vitamins.
  • Proton pump inhibitors: can reduce absorption of cyanocobalamin.

Frequently Asked Questions

Neurobion Advance is a vitamin B complex supplement that provides cyanocobalamin (B12), thiamine nitrate (B1) and pyridoxine hydrochloride (B6). It is used to treat or prevent deficiencies of these B‑vitamins and to support nerve health in conditions such as peripheral neuropathy linked to B‑vitamin shortage.

Cyanocobalamin serves as a co‑factor for enzymes involved in DNA synthesis and myelin formation. Thiamine nitrate is converted to thiamine pyrophosphate, essential for carbohydrate metabolism and neuronal energy production. Pyridoxine hydrochloride becomes pyridoxal‑5′‑phosphate, a co‑factor in amino‑acid metabolism, neurotransmitter synthesis and red‑blood‑cell formation. Together they support metabolic pathways critical for nerve and blood health.

The appropriate dose of Neurobion Advance is determined by a qualified healthcare professional based on the individual’s age, clinical condition and laboratory results. Prescribers may adjust the amount and frequency to meet specific therapeutic goals, and patients should follow the prescribed regimen without deviation.

Neurobion Advance may be used during pregnancy or lactation only when clearly needed and after a risk‑benefit assessment by a physician. While the B‑vitamins are essential nutrients, the decision to continue therapy should be made in consultation with a healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Neurobion Advance combines three specific B‑vitamins—B12, B1 and B6—in a single oral formulation, offering a targeted approach for deficiency‑related neuropathy and anemia. Compared with generic B‑complex tablets that may contain additional vitamins, Neurobion focuses on the three most relevant nutrients for nerve and hematopoietic support, often preferred in clinical settings.

Store Neurobion Advance at ambient temperature below 25 °C, in its original packaging, protected from moisture and direct sunlight. Keep the container tightly closed and out of reach of children. No refrigeration is required for this oral tablet.

Neurobion Advance is taken orally, typically with water. The tablet should be swallowed whole and not crushed or chewed unless otherwise directed by a healthcare professional. It can be taken with or without food, depending on the prescriber’s advice.

Serious adverse reactions, although rare, include anaphylaxis, Stevens‑Johnson syndrome, hemolytic anemia and severe hypersensitivity such as facial swelling or breathing difficulty. Patients should seek immediate medical attention if they experience any signs of a severe allergic reaction or unexplained blood‑related symptoms.

Individuals with a known hypersensitivity to cyanocobalamin, thiamine nitrate, pyridoxine hydrochloride or any excipients in the tablet should avoid Neurobion Advance. It is also contraindicated in patients who have experienced severe allergic reactions to similar vitamin B preparations.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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