Product image of Neurobion (Thiamine Hydrochloride, Cyanocobalamin, Pyridoxine Hydrochloride) supplied by GNH India

Neurobion

Active Ingredient:
Thiamine Hydrochloride, Cyanocobalamin, Pyridoxine Hydrochloride
Origin:
EU

Neurobion (Thiamine Hydrochloride, Cyanocobalamin, Pyridoxine Hydrochloride)

Thiamine Hydrochloride, Pyridoxine Hydrochloride, and Cyanocobalamin, the active ingredients in Neurobion, are a Vitamin B complex presented as an injection solution for intramuscular use. The product is used to treat deficiencies of vitamins B1, B6, and B12 and associated conditions such as peripheral neuropathy and certain anemias.

GNH India supplies Neurobion as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable cold‑chain logistics for injectable products across multiple regulatory markets.

Manufacturer / TM Owner

P&g Health Germany Gmbh

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Indications & Clinical Uses

Neurobion is indicated for conditions related to vitamin B‑complex deficiency and the neurological pathways they support.

  • Vitamin B1, B6, and B12 deficiency: restores normal B‑vitamin levels and alleviates associated symptoms.
  • Peripheral neuropathy: helps improve nerve function and reduces sensory disturbances.
  • Anemia due to B‑vitamin deficiency: supports red blood cell formation and corrects hematologic abnormalities.
  • Pregnancy and lactation support when deficiency is suspected: contributes to maternal and infant nutritional status.

How It Works

  • The three B‑vitamins act as essential co‑enzymes in metabolic pathways. Thiamine (B1) participates in carbohydrate decarboxylation, pyridoxine (B6) is required for amino‑acid transamination and neurotransmitter synthesis, and cyanocobalamin (B12) facilitates methylmalonyl‑CoA mutase activity and homocysteine remethylation. Together they support energy production, myelin formation and erythropoiesis, correcting the biochemical deficits underlying deficiency states.

Side Effects

Injection of Neurobion may be associated with the following adverse reactions.

Common Side Effects

  • Pain or tenderness at the injection site
  • Redness or mild swelling locally
  • Low‑grade fever
  • Headache
  • Nausea

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Hypotension or shock
  • Thrombophlebitis at the injection site
  • Persistent neurological symptoms
  • Hemolytic anemia (very rare)

Precautions & Warnings

Before administering Neurobion, consider these precautionary measures.

  • Assess vitamin B status: confirm deficiency or clinical indication before use.
  • Monitor for hypersensitivity: discontinue if signs of rash, swelling, or respiratory difficulty appear.
  • Use with caution in patients with renal impairment: adjust monitoring as needed.
  • Avoid intramuscular injection into areas of infection or inflammation.
  • Pregnant or breastfeeding women: evaluate risk‑benefit ratio and consult obstetric guidance.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Neurobion can interact with certain medicines, requiring attention to the following categories.

Major Interactions (Avoid)

  • Metformin: high-dose B12 may mask metformin‑induced B12 deficiency, requiring monitoring.
  • Tetracycline antibiotics: chelation may reduce absorption of oral B‑vitamins (though injection less affected).

Moderate Interactions (Monitor Closely)

  • Anticonvulsants (e.g., phenytoin, carbamazepine): may increase vitamin B6 turnover, necessitating dosage review.
  • Levothyroxine: high doses of B‑vitamins can alter thyroid hormone metabolism; monitor thyroid function tests.
  • Chemotherapy agents (e.g., methotrexate): may affect folate pathways; observe for additive hematologic effects.

Frequently Asked Questions

Neurobion is a vitamin B complex injection that supplies thiamine (B1), pyridoxine (B6) and cyanocobalamin (B12). It is used to correct deficiencies of these B‑vitamins, to support nerve health in peripheral neuropathy, and to treat anemia that results from inadequate B‑vitamin levels.

Each component acts as a co‑enzyme in essential metabolic pathways. Thiamine assists carbohydrate breakdown, pyridoxine is vital for amino‑acid metabolism and neurotransmitter synthesis, and cyanocobalamin participates in DNA synthesis and red blood cell formation. Together they restore normal metabolic function when B‑vitamin stores are low.

The dose of Neurobion is determined by the prescribing healthcare professional based on the patient’s age, clinical condition and severity of deficiency. Typical regimens may involve a single intramuscular injection or a series of injections, but exact dosing must be individualized by the prescriber.

Neurobion may be used during pregnancy or lactation when a vitamin B deficiency is confirmed or strongly suspected, but only after a risk‑benefit assessment by the treating physician. The injectable form bypasses gastrointestinal absorption issues, yet professional guidance is essential to ensure safety for mother and infant.

To place an order, submit an enquiry on the Neurobion product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling) and any necessary import documentation.

Neurobion delivers the three B‑vitamins as an injectable solution, which ensures rapid bioavailability and is useful when oral absorption is compromised. Oral B‑complex tablets are convenient for routine supplementation, but may be less effective in severe deficiency or malabsorption states. The choice depends on clinical need, patient preference and physician judgment.

Neurobion should be stored at 2‑8 °C in a refrigerator, protected from light. The vial must not be frozen or shaken vigorously. Keep the product in its original packaging until use and discard any solution that appears discolored or contains particles.

Neurobion is administered by a qualified healthcare professional as an intramuscular injection, typically into the deltoid or gluteal muscle. The injection should be given using aseptic technique, and the site should be observed for any immediate local reaction.

The most serious adverse events include severe allergic reactions such as anaphylaxis, hypotension or shock, and rare hematologic complications like hemolytic anemia. Patients should be monitored for signs of rash, swelling, breathing difficulty, or sudden drop in blood pressure after injection.

Neurobion is contraindicated in individuals with a known hypersensitivity to any of its active ingredients or to the excipients in the formulation. Caution is also advised for patients with severe renal impairment, uncontrolled hypertension, or those who have experienced previous severe reactions to vitamin B injections.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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