Product image of Neurol (Alprazolam) supplied by GNH India

Neurol

Active Ingredient:
Alprazolam
Origin:
EU

Neurol (Alprazolam)

Alprazolam, the active ingredient in Neurol, is a benzodiazepine presented as an oral tablet for oral use. It is prescribed to manage anxiety disorders and panic disorder in adult patients.\n\nGNH India supplies Neurol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

  • Alprazolam belongs to the benzodiazepine class and is used to treat conditions related to excessive central nervous system excitation.\n\n- Anxiety disorders: reduces excessive worry and tension, helping patients regain functional daily activity.\n- Panic disorder: decreases the frequency and intensity of panic attacks, providing rapid symptom control.\n- Short‑term management of acute anxiety: offers quick relief of situational anxiety symptoms while longer‑term strategies are implemented.

How It Works

  • Alprazolam acts as a positive allosteric modulator at the GABA‑A receptor complex. By binding to the benzodiazepine site, it enhances the inhibitory effect of the neurotransmitter gamma‑aminobutyric acid, increasing chloride ion influx and hyperpolarizing neuronal membranes, which results in reduced neuronal excitability and a calming effect.

Side Effects

  • Alprazolam may cause a range of adverse reactions, from mild to severe. Patients should be aware of both common and less frequent side effects.\n\nCommon Side Effects:\n- Drowsiness: feeling unusually sleepy or fatigued.\n- Dizziness: light‑headed sensation, especially when standing quickly.\n- Impaired coordination: reduced motor control or clumsiness.\n- Memory disturbances: difficulty recalling recent events.\n- Gastrointestinal upset: nausea or abdominal discomfort.\n\nSerious or Rare Side Effects:\n- Respiratory depression: slowed or shallow breathing, especially with other depressants.\n- Severe allergic reaction: rash, itching, swelling, or difficulty breathing.\n- Mood changes: depression, suicidal thoughts, or aggression.\n- Dependence or withdrawal: physical or psychological reliance after prolonged use.

Precautions & Warnings

  • Before initiating therapy with alprazolam, consider the following safety measures.\n\n- Assess medical history: evaluate for respiratory disorders, liver impairment, or a history of substance abuse.\n- Pregnancy and lactation: avoid use in pregnancy (Category D) and breastfeeding unless benefits outweigh risks.\n- Concomitant CNS depressants: limit use with alcohol, opioids, or other sedatives to reduce respiratory depression risk.\n- Elderly patients: start at the lowest effective dose and monitor for falls or confusion.\n- Discontinuation: taper gradually under medical supervision to prevent withdrawal symptoms.\n- Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

  • Alprazolam can interact with several drug classes, altering its efficacy or safety profile.\n\nMajor Interactions (Avoid):\n- Opioids: combined use may cause profound respiratory depression.\n- Alcohol: additive CNS depression leading to excessive sedation.\n- Barbiturates: may enhance sedative effects and increase overdose risk.\n- Certain antifungals (e.g., ketoconazole): can raise alprazolam plasma levels.\n- Macrolide antibiotics (e.g., erythromycin): may increase drug concentration.\n\nModerate Interactions (Monitor Closely):\n- CYP3A4 inhibitors (e.g., fluoxetine, grapefruit juice): may require dose adjustment.\n- Antidepressants (e.g., SSRIs): monitor for enhanced sedation.\n- Antihistamines: may increase drowsiness.\n- Antihypertensives: watch for additive hypotensive effects.\n- Oral contraceptives: possible alteration of hormone levels.

Frequently Asked Questions

Neurol contains alprazolam, a benzodiazepine indicated for the short‑term treatment of anxiety disorders and panic disorder in adults. It helps reduce excessive worry, tension, and the frequency of panic attacks, allowing patients to function more normally in daily activities.

Alprazolam binds to the benzodiazepine site on the GABA‑A receptor complex, enhancing the natural inhibitory action of GABA. This increases chloride ion flow into neurons, hyperpolarizing them and decreasing neuronal excitability, which produces a calming and anxiolytic effect.

The appropriate dose of Neurol is determined by the prescribing clinician based on the individual’s medical condition, age, and response to therapy. Dosage adjustments may be needed for elderly patients or those with liver impairment, and the prescriber will provide specific instructions.

Alprazolam is classified as Pregnancy Category D, indicating evidence of risk to the fetus. It is generally avoided during pregnancy unless the potential benefit justifies the risk. Use while breastfeeding is also discouraged because the drug can pass into breast milk and affect the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Neurol (alprazolam) is a short‑acting benzodiazepine, offering rapid onset of symptom relief compared with longer‑acting agents such as diazepam. While effective for acute anxiety and panic attacks, its higher potency and risk of dependence require careful monitoring, unlike some non‑benzodiazepine anxiolytics that have a slower onset but lower abuse potential.

Neurol should be stored at temperatures below 25 °C in its original packaging. Keep the product away from moisture, direct sunlight, and heat sources to maintain its stability and potency throughout its shelf life.

Neurol is taken orally, usually as a tablet, with or without food as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

The most serious risks include respiratory depression, especially when combined with other central nervous system depressants, severe allergic reactions, and the potential for physical dependence and withdrawal symptoms after prolonged use. Patients should seek immediate medical attention if they experience difficulty breathing, rash, or sudden mood changes.

Neurol is contraindicated in individuals with known hypersensitivity to alprazolam or other benzodiazepines, those with acute narrow‑angle glaucoma, and patients who are currently abusing alcohol or other depressant substances. Caution is also advised for patients with severe respiratory insufficiency or uncontrolled severe liver disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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