Neurontin (Gabapentin)

Gabapentin binds to the α2‑δ subunit of voltage‑gated calcium channels in the central nervous system. This reduces calcium entry into neurons, which in turn lowers the release of excitatory neurotransmitters such as glutamate and substance P, dampening abnormal neuronal firing that contributes to seizures and neuropathic pain.

The appropriate dose of Neurontin is individualized by the prescribing clinician based on the specific indication, patient age, renal function and treatment response. Healthcare providers determine the starting dose and any titration schedule, so patients should follow the prescriber’s written instructions.

The pregnancy safety category for gabapentin is not definitively established. It should be used during pregnancy only when the potential benefit justifies any potential risk to the fetus. Gabapentin is excreted in breast milk; therefore, breastfeeding mothers should discuss potential risks and benefits with their healthcare professional.

To place an order, visit the product page on gnhindia.com, enter the required quantity and submit the enquiry form. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Both gabapentin and pregabalin belong to the gabapentinoid class and share a similar mechanism of binding to the α2‑δ calcium‑channel subunit. Pregabalin generally has higher bioavailability and may require lower doses, while gabapentin often needs dose titration and may have more variable absorption. Choice between them depends on clinical response, tolerability, cost and prescriber preference.

Neurontin tablets should be stored at ambient temperature, below 25 °C, in their original container to protect from moisture and light. Keep the product out of reach of children and do not use after the expiration date printed on the packaging.

Neurontin is taken orally as a tablet. Patients should swallow the tablet whole with a full glass of water. It may be taken with or without food, but consistent timing with respect to meals can help maintain steady drug levels. The prescribing clinician will provide specific instructions on frequency and timing.

Serious adverse reactions, although rare, include severe skin reactions such as Stevens‑Johnson syndrome, anaphylaxis, suicidal thoughts or behaviors, respiratory depression (especially when combined with other CNS depressants), angioedema, and significant blood disorders like agranulocytosis. Patients should seek immediate medical attention if any of these symptoms occur.

Neurontin should not be used by individuals with known hypersensitivity to gabapentin or any of its excipients. Caution is advised in patients with severe renal impairment, as dose adjustment may be required, and in those with a history of suicidal ideation. Pregnant or breastfeeding women should only use it when clearly indicated by a healthcare professional.