Product image of Neurontin (Gabapentin) supplied by GNH India

Neurontin

Active Ingredient:
Gabapentin
Origin:
EU

Neurontin (Gabapentin)

Gabapentin, the active ingredient in Neurontin, is a GABA analog anticonvulsant presented as an oral formulation for oral use. It is prescribed for the management of partial seizures and various neuropathic pain conditions, including post‑herpetic neuralgia, diabetic peripheral neuropathy, and restless‑legs syndrome, in adult patients.

GNH India supplies Neurontin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets. Our distribution network adheres to stringent quality standards and facilitates reliable access to essential medicines.

Manufacturer / TM Owner

Upjohn Eesv

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Indications & Clinical Uses

Neurontin (gabapentin) acts on neuronal calcium channels to treat several seizure‑related and neuropathic pain disorders.

  • Partial seizures: reduces seizure frequency in adults with focal epilepsy.
  • Post‑herpetic neuralgia: alleviates chronic pain following shingles infection.
  • Diabetic peripheral neuropathic pain: diminishes burning and tingling sensations in diabetic patients.
  • Restless‑legs syndrome: lessens uncomfortable leg sensations and urges to move, improving sleep quality.

How It Works

  • Gabapentin binds selectively to the α2‑δ subunit of voltage‑gated calcium channels in the central nervous system. This binding decreases calcium influx into presynaptic neurons, which in turn reduces the release of excitatory neurotransmitters such as glutamate, substance P, and norepinephrine, thereby dampening neuronal hyperexcitability associated with seizures and neuropathic pain.

Side Effects

Common Side Effects

  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Somnolence: increased sleepiness or fatigue.
  • Peripheral edema: swelling of the lower extremities.
  • Weight gain: gradual increase in body weight.
  • Ataxia: loss of coordination and balance.
  • Fatigue: general feeling of tiredness.

Serious or Rare Side Effects

  • Suicidal thoughts or behavior: mood changes requiring immediate medical attention.
  • Severe allergic reactions: including Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Respiratory depression: especially when combined with other CNS depressants.
  • Angioedema: rapid swelling of face, lips, or throat.
  • Blood dyscrasias: such as agranulocytosis or thrombocytopenia.
  • Hepatic failure: signs of liver dysfunction requiring urgent care.

Precautions & Warnings

Neurontin should be used with careful clinical assessment and monitoring.

  • Renal function: dose adjustment may be required in patients with impaired renal clearance.
  • Pregnancy: safety not established; prescribe only if potential benefit outweighs risk.
  • Suicidality: monitor for mood changes and suicidal ideation throughout therapy.
  • Driving: caution advised due to possible dizziness or somnolence.
  • Drug interactions: review concomitant medications for CNS depressants.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Gabapentin may interact with several medications, requiring vigilance.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: may reduce gabapentin absorption.
  • Opioids: increased risk of respiratory depression and sedation.
  • CNS depressants (benzodiazepines, barbiturates): additive central nervous system depression.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may increase gabapentin plasma levels.
  • Diuretics: may affect renal clearance of gabapentin.
  • Carbamazepine: may reduce gabapentin efficacy.

Frequently Asked Questions

Neurontin, whose active ingredient is gabapentin, is prescribed to control partial (focal) seizures and to relieve neuropathic pain conditions such as post‑herpetic neuralgia, diabetic peripheral neuropathy, and restless‑legs syndrome in adult patients.

Gabapentin binds to the α2‑δ subunit of voltage‑gated calcium channels in the central nervous system, reducing calcium influx and consequently decreasing the release of excitatory neurotransmitters. This modulation lowers neuronal hyperexcitability, helping to control seizures and neuropathic pain signals.

The appropriate dose of Neurontin is individualized by the prescribing clinician based on the patient’s condition, renal function, and response to therapy. Dosage regimens may vary, and the prescriber determines the exact amount and frequency.

Safety data for gabapentin in pregnancy are limited, and the drug is classified as pregnancy category unknown. It should be used only if the potential benefit justifies any possible risk to the fetus. Breastfeeding mothers should consult their healthcare provider, as gabapentin is excreted in breast milk.

To place an order, submit an enquiry on the Neurontin product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Gabapentin and pregabalin (Lyrica) belong to the same class of GABA analog anticonvulsants and share a similar mechanism of binding to the α2‑δ calcium‑channel subunit. Pregabalin generally has higher bioavailability and may require lower doses, while gabapentin is often less expensive but may need higher or more frequent dosing to achieve comparable effects.

Neurontin should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and excessive heat. Keep the container tightly closed and out of reach of children.

Neurontin is administered orally, usually as tablets or capsules, and should be taken with or without food as directed by the prescriber. Swallow the dosage form whole with a full glass of water; do not crush or chew unless specifically instructed.

Serious risks include the emergence of suicidal thoughts or behavior, severe allergic reactions such as Stevens‑Johnson syndrome, respiratory depression when combined with other CNS depressants, angioedema, and rare blood disorders. Patients should seek immediate medical attention if any of these symptoms appear.

Neurontin is contraindicated in patients with known hypersensitivity to gabapentin or any of the product’s excipients. Caution is advised for individuals with severe renal impairment, as dose adjustment is required, and for those taking multiple CNS depressants due to increased risk of sedation and respiratory depression.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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