Neuroplant (St. John´s Wort Dry Extract, Quantified, Der 3-7:1, Extraction Solvent: Methanol 80 % (V/V))

• Neuroplant, containing St. John's Wort, modulates serotonin, dopamine and norepinephrine pathways implicated in depressive and mood disorders.
• Mild to moderate depression: helps improve mood and reduce depressive symptoms.
• Seasonal affective disorder: alleviates depressive symptoms associated with seasonal changes.
• Generalized anxiety (off‑label): may reduce anxiety symptoms in some individuals.
• Post‑viral fatigue (off‑label): may support energy levels and mood.

• St. John's Wort dry extract exerts its effect primarily by inhibiting the reuptake of serotonin, dopamine and norepinephrine, thereby increasing their synaptic concentrations. The extract also modulates various receptor activities, including antagonism of α‑adrenergic receptors and activation of transient receptor potential channels, and influences the expression of neurotrophic factors, contributing to its antidepressant and mood‑stabilising properties.

St. John's Wort may be associated with a range of adverse reactions, varying from mild to serious.

Common Side Effects

• Gastrointestinal discomfort: nausea, abdominal cramps or diarrhea.
• Headache: mild to moderate intensity.
• Dizziness or light‑headedness.
• Fatigue or drowsiness.
• Skin reactions: mild rash or photosensitivity.

Serious or Rare Side Effects

• Serotonin syndrome: risk when combined with other serotonergic agents.
• Severe allergic reaction: anaphylaxis or angioedema.
• Significant drug‑interaction‑induced toxicity: e.g., reduced efficacy of oral contraceptives, anticoagulants, immunosuppressants.

• When considering Neuroplant, several safety measures and warnings should be observed.
• Pregnancy and lactation: use only if clearly needed, as safety data are limited.
• Concurrent serotonergic therapy: avoid co‑administration to reduce serotonin syndrome risk.
• Photosensitivity: limit exposure to strong sunlight or UV lamps.
• Medication review: assess for potential interactions with anticoagulants, oral contraceptives, antiretrovirals, and immunosuppressants.
• Monitoring: observe for changes in mood, anxiety or suicidal thoughts, especially at treatment initiation.
• Store at ambient temperature: keep in the original container, protect from moisture and direct light.

St. John's Wort is known to affect the metabolism of several drugs through enzyme induction and transporter inhibition.

Major Interactions (Avoid)

• Oral contraceptives: reduced plasma levels leading to contraceptive failure.
• Anticoagulants (e.g., warfarin): decreased effect increasing clot risk.
• Immunosuppressants (e.g., cyclosporine, tacrolimus): lowered concentrations causing graft rejection.
• Antiretroviral agents (e.g., protease inhibitors): diminished efficacy of HIV therapy.
• Serotonergic antidepressants (e.g., SSRIs, SNRIs, MAOIs): heightened risk of serotonin syndrome.

Moderate Interactions (Monitor Closely)

• Antidepressants with serotonergic activity: monitor for serotonin syndrome symptoms.
• Antiepileptic drugs (e.g., carbamazepine, phenytoin): possible altered levels.
• Statins metabolised by CYP3A4: potential reduction in lipid‑lowering effect.
• Beta‑blockers (e.g., propranolol): may experience decreased efficacy.
• Caffeine: increased metabolism may reduce stimulant effect.