Product image of Nevanac (Nepafenac) supplied by GNH India

Nevanac

Active Ingredient:
Nepafenac
Origin:
EU

Nevanac (Nepafenac)

Nepafenac, the active ingredient in Nevanac, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as an ophthalmic suspension for ocular use. It treats post‑operative inflammation and pain following cataract surgery in adults.

GNH India supplies Nevanac as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Novartis Europharm Limited

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Indications & Clinical Uses

Nevanac (nepafenac) is used to manage ocular inflammation and pain associated with surgical procedures.

  • Post‑operative inflammation after cataract surgery: reduces inflammatory response in the operated eye.
  • Post‑operative pain after cataract surgery: alleviates discomfort and pain.
  • Anterior segment inflammation: helps control inflammation following ocular surgery.

How It Works

  • After topical application, nepafenac penetrates the cornea and is hydrolyzed by intra‑ocular hydrolases to its active form, amfenac. Amfenac selectively inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, decreasing prostaglandin synthesis and thereby limiting inflammation and pain signals within ocular tissues.

Side Effects

Common Side Effects

  • Burning or stinging sensation on instillation.
  • Foreign body sensation.
  • Blurred vision.
  • Conjunctival hyperemia.
  • Itching or mild irritation.
  • Transient increased tear production.

Serious or Rare Side Effects

  • Corneal ulceration or keratitis.
  • Significant increase in intra‑ocular pressure.
  • Severe allergic reactions such as angioedema.
  • Persistent eye pain.
  • Vision loss or sudden visual disturbances.
  • Endophthalmitis (infection inside the eye).

Precautions & Warnings

Before prescribing Nevanac, clinicians should consider ocular health and patient history.

  • Assess for active ocular infection: avoid use if infection is present.
  • Known hypersensitivity: do not use in patients allergic to nepafenac or other NSAIDs.
  • Concomitant ocular NSAIDs: avoid simultaneous use to reduce toxicity risk.
  • Monitor intra‑ocular pressure in patients with glaucoma or ocular hypertension.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Nevanac may interact with other ophthalmic or systemic agents.

Major Interactions (Avoid)

  • Concurrent use with other ophthalmic NSAIDs: increased risk of corneal toxicity.
  • Simultaneous corticosteroid eye drops: may mask signs of infection.
  • Systemic NSAIDs: additive systemic exposure, though minimal with topical use.

Moderate Interactions (Monitor Closely)

  • Anticholinergic eye drops: possible reduction in therapeutic effect.
  • Beta‑blocker eye drops: monitor intra‑ocular pressure changes.
  • Preservative‑containing solutions: assess for additive irritation.

Frequently Asked Questions

Nevanac is an ophthalmic suspension containing nepafenac that is prescribed to reduce inflammation and relieve pain after cataract surgery. It is specifically indicated for post‑operative ocular inflammation and discomfort in the treated eye.

After instillation, nepafenac penetrates the cornea and is converted by ocular enzymes into amfenac, an active NSAID. Amfenac blocks cyclooxygenase‑1 and cyclooxygenase‑2, lowering prostaglandin production, which in turn diminishes inflammation and pain signals within the eye.

The dosing regimen for Nevanac is determined by the prescribing ophthalmologist. Typically, the doctor will advise the number of drops, frequency, and duration based on the individual patient's surgical outcome and response.

Safety of nepafenac during pregnancy or lactation has not been definitively established. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified health professional.

To order Nevanac, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Nevanac is a pro‑drug formulation that offers rapid corneal penetration and conversion to the active amfenac, providing effective anti‑inflammatory action with a relatively low incidence of ocular irritation compared with some older NSAID eye drops. Clinical choice depends on physician preference, patient tolerance and specific surgical context.

Nevanac should be stored at room temperature, below 25 °C, in its original container. Keep the bottle tightly closed, protect it from direct light and moisture, and avoid freezing. Do not use the product if the suspension appears discoloured or contains particles.

Nevanac is applied as a sterile eye drop. The patient instills the prescribed number of drops into the affected eye(s) according to the ophthalmologist’s instructions, typically avoiding contact between the dropper tip and the eye or any surface to maintain sterility.

Serious risks, although rare, include corneal ulceration or keratitis, significant increases in intra‑ocular pressure, severe allergic reactions such as angioedema, and sudden vision loss. Any unexpected pain, redness, or visual changes should prompt immediate medical evaluation.

Nevanac should not be used by individuals with known hypersensitivity to nepafenac, amfenac, or any component of the formulation, and it is contraindicated in eyes with active infection. Caution is also advised for patients with a history of severe ocular surface disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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