Product image of Nevanac (Nepafenac) supplied by GNH India

Nevanac

Active Ingredient:
Nepafenac
Origin:
EU

Nevanac (Nepafenac)

Nepafenac, the active ingredient in Nevanac, is a NSAID presented as an ophthalmic solution for ocular use. It is employed to manage post‑operative inflammation and pain following cataract surgery and other ocular inflammatory conditions in adult patients. The drug works by inhibiting cyclooxygenase enzymes, thereby reducing prostaglandin synthesis within eye tissues.

GNH India supplies Nevanac as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, pharmacies and clinics worldwide. Our distribution network ensures consistent quality and regulatory compliance across multiple markets.

Manufacturer / TM Owner

Novartis Europharm Limited

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Indications & Clinical Uses

Nevanac is an ophthalmic NSAID used to treat inflammation and pain in ocular surgery and disease contexts.

  • Cataract surgery: reduces inflammation and pain after the procedure.
  • Ocular inflammation: controls inflammatory response in the eye.
  • Post‑operative ocular pain: provides analgesia following eye surgeries.

How It Works

  • After topical administration, nepafenac penetrates the cornea and is hydrolyzed to its active form, amfenac. Amfenac selectively inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes in ocular tissues, decreasing prostaglandin synthesis and thereby limiting the inflammatory cascade that leads to pain, swelling, and cellular infiltration in the eye.

Side Effects

Adverse reactions may occur with any ophthalmic medication. Patients should be aware of both common and serious potential effects.

Common Side Effects

  • Eye irritation: mild burning or stinging after instillation.
  • Redness: conjunctival hyperemia.
  • Blurred vision: temporary visual disturbance.
  • Tearing: increased lacrimation.
  • Foreign body sensation: feeling of something in the eye.
  • Photophobia: light sensitivity.

Serious or Rare Side Effects

  • Corneal ulceration: breakdown of corneal epithelium.
  • Increased intra‑ocular pressure: may exacerbate glaucoma.
  • Severe allergic reaction: swelling, itching, or rash around the eye.
  • Vision loss: sudden decrease in visual acuity.
  • Persistent eye pain: may indicate deeper ocular injury.
  • Endophthalmitis: intra‑ocular infection.

Precautions & Warnings

Before prescribing Nevanac, clinicians should consider several safety factors.

  • Assess for ocular infection: avoid use if active infection is present.
  • Hypersensitivity: discontinue if patient shows allergic reaction to nepafenac or other NSAIDs.
  • Corneal disease: use with caution in patients with compromised corneal integrity.
  • Intra‑ocular pressure: monitor patients with glaucoma or ocular hypertension.
  • Concurrent ocular NSAIDs: avoid simultaneous use to reduce risk of corneal toxicity.
  • Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Nevanac may interact with other ophthalmic or systemic agents; awareness of interaction severity guides clinical decisions.

Major Interactions (Avoid)

  • Concurrent ophthalmic NSAIDs: increased risk of corneal toxicity.
  • Systemic anticoagulants: potential for enhanced ocular bleeding.

Moderate Interactions (Monitor Closely)

  • Corticosteroid eye drops: additive anti‑inflammatory effect, monitor healing.
  • Contact lens wear: may cause discomfort or reduced drug efficacy.
  • Prostaglandin analogs for glaucoma: monitor intra‑ocular pressure changes.
  • Systemic NSAIDs: watch for additive systemic side effects.
  • Topical anesthetics: may increase corneal irritation.

Frequently Asked Questions

Nevanac is a prescription ophthalmic solution containing nepafenac, indicated for the treatment of post‑operative inflammation and pain following cataract surgery and for managing other ocular inflammatory conditions in adults.

After instillation, nepafenac penetrates the cornea and is converted to amfenac, which inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes. This reduces prostaglandin production, thereby limiting inflammation, swelling, and pain within ocular tissues.

The dosing regimen for Nevanac is determined by the prescribing ophthalmologist based on the specific surgical procedure and patient characteristics. Patients should follow the prescriber’s instructions and not alter the dose on their own.

Safety of nepafenac in pregnancy or lactation has not been definitively established. Clinicians should weigh potential benefits against unknown risks and consider alternative therapies when treating pregnant or nursing patients.

To request Nevanac, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nevanac (nepafenac) is a non‑steroidal anti‑inflammatory eye drop, offering anti‑inflammatory and analgesic effects without the steroid‑related risks of increased intra‑ocular pressure. Compared with corticosteroid drops, it has a lower risk of cataract formation but may be less potent for severe inflammation.

Nevanac should be stored at room temperature, below 25 °C, in its original container. Protect the product from moisture and direct sunlight. Do not freeze or expose it to extreme temperatures, and keep the bottle tightly closed when not in use.

Nevanac is applied as eye drops. The prescriber will instruct the patient on the number of drops per eye, frequency of administration and duration of therapy, typically beginning shortly after surgery and continuing for several days as directed.

Serious risks, though rare, include corneal ulceration, increased intra‑ocular pressure, severe allergic reactions, and vision loss. Patients should seek immediate ophthalmic evaluation if they experience persistent pain, worsening vision, or signs of infection.

Nevanac should not be used by individuals with known hypersensitivity to nepafenac, other NSAIDs, or any component of the formulation. It is also contraindicated in eyes with active infection or severe corneal disease until those conditions are resolved.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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