Product image of Nevirapin Axiromed (Nevirapine) supplied by GNH India

Nevirapin Axiromed

Active Ingredient:
Nevirapine
Origin:
EU

Nevirapin Axiromed (Nevirapine)

Nevirapine, the active ingredient in Nevirapin Axiromed, is a non‑nucleoside reverse transcriptase inhibitor presented as a tablet for oral use. It is used to treat HIV‑1 infection in adults and adolescents, helping to suppress viral replication and improve immune function. Nevirapine belongs to the NNRTI class and works by binding to a specific site on the HIV‑1 reverse transcriptase enzyme, causing a conformational change that blocks the enzyme’s activity.

GNH India supplies Nevirapin Axiromed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medical Valley Invest Ab

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Indications & Clinical Uses

Nevirapin Axiromed is indicated for the treatment of HIV‑1 infection, targeting the viral replication pathway.

  • HIV‑1 infection: reduces viral load and helps restore immune function in adults and adolescents.

How It Works

  • Nevirapine acts by binding to a non‑nucleoside site on the HIV‑1 reverse transcriptase enzyme. This binding induces a conformational change that impairs the enzyme’s ability to convert viral RNA into DNA, thereby halting the synthesis of proviral DNA and preventing subsequent integration into the host genome. The inhibition is reversible and does not compete with the natural nucleoside substrates, allowing selective suppression of viral replication while sparing host polymerases.

Side Effects

Nevirapine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Rash: mild skin redness or itching.
  • Nausea: upset stomach or feeling of queasiness.
  • Fatigue: general tiredness or lack of energy.
  • Headache: mild to moderate head pain.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe skin blistering and mucosal involvement.
  • Hepatotoxicity: elevated liver enzymes, jaundice, or liver failure.
  • Hypersensitivity reaction: fever, eosinophilia, and multi‑organ involvement.

Precautions & Warnings

When prescribing Nevirapin Axiromed, clinicians should observe several safety measures to minimise risk.

  • Monitor liver function: obtain baseline and periodic liver enzyme tests.
  • Assess for rash: examine patients regularly for signs of severe skin reactions.
  • Avoid in known hypersensitivity: discontinue if allergic response occurs.
  • Use caution in pregnancy: consider potential hepatic toxicity and discuss risks with the patient.
  • Store at ambient temperature (below 25°C): keep in the original container, protect from moisture.

Avoid Interactions

Nevirapin Axiromed can interact with other medicines that affect its metabolism or increase toxicity.

Major Interactions (Avoid)

  • Ritonavir: potent CYP3A4 inhibition can raise nevirapine levels, heightening hepatotoxic risk.
  • Efavirenz: combined NNRTIs may lead to reduced efficacy and increased adverse events.
  • St. John’s wort: strong CYP3A4 induction can markedly lower nevirapine concentrations.

Moderate Interactions (Monitor Closely)

  • Carbamazepine: enzyme induction may decrease nevirapine exposure, requiring viral load monitoring.
  • Antacids (aluminum‑magnesium): may reduce oral absorption of nevirapine; separate dosing times.
  • Methadone: nevirapine may reduce methadone levels, potentially precipitating withdrawal.

Frequently Asked Questions

Nevirapin Axiromed contains nevirapine, an antiretroviral medication used to treat HIV‑1 infection. It helps suppress viral replication, reduces the amount of virus in the blood, and supports recovery of the immune system in adults and adolescents living with HIV.

Nevirapine belongs to the non‑nucleoside reverse transcriptase inhibitor (NNRTI) class. It binds to a specific non‑nucleoside site on the HIV‑1 reverse transcriptase enzyme, causing a conformational change that blocks the enzyme’s ability to convert viral RNA into DNA, thereby halting viral replication.

The dosing regimen for Nevirapin Axiromed is determined by the prescribing clinician based on the patient’s clinical status, weight, and treatment guidelines. Physicians typically start with a loading dose followed by a maintenance dose, but the exact schedule should be individualized and confirmed by the prescriber.

Safety data for nevirapine in pregnancy and lactation are limited. While it may be used when the benefits outweigh potential risks, clinicians should monitor liver function closely and discuss possible fetal or infant exposure with the patient. Breastfeeding decisions should follow local guidelines and professional advice.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials. The sales team will then respond with pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Nevirapin Axiromed (nevirapine) is one of several NNRTIs used for HIV‑1 therapy. Compared with agents such as efavirenz or rilpivirine, nevirapine has a longer history of use and a distinct side‑effect profile, including a higher risk of rash and hepatotoxicity. Choice of NNRTI depends on patient tolerance, resistance patterns, drug‑drug interactions and treatment guidelines.

Nevirapin Axiromed should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in their original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability throughout its shelf life.

Nevirapin Axiromed is taken orally, usually with food or a light snack to improve absorption and reduce gastrointestinal discomfort. The tablets should be swallowed whole with a full glass of water and not crushed or chewed unless specifically instructed by a healthcare professional.

The most serious adverse events associated with nevirapine include severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, and hepatotoxicity that can progress to liver failure. Patients should be educated to report any rash, blistering, jaundice, dark urine, or unexplained fatigue promptly.

Nevirapin Axiromed should be avoided in individuals with a known hypersensitivity to nevirapine or any component of the formulation. It is also contraindicated in patients with pre‑existing severe liver disease or a history of severe cutaneous adverse reactions to NNRTIs. Clinicians must assess each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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