Product image of Nevirapin (Nevirapine) supplied by GNH India

Nevirapin

Active Ingredient:
Nevirapine
Origin:
EU

Nevirapin (Nevirapine)

Nevirapine, the active ingredient in Nevirapin, is a non‑nucleoside reverse transcriptase inhibitor (NNRTI) presented as an oral tablet for oral use. It is employed in combination antiretroviral regimens to treat HIV‑1 infection in adults and children, helping to suppress viral replication and improve immune status.

GNH India supplies Nevirapin as a licensed, GDP‑compliant international pharmaceutical supplier. The company provides the product to hospitals, pharmacies, and clinics worldwide, ensuring quality‑assured medication for antiretroviral programmes and supporting global HIV treatment initiatives and patient care.

Manufacturer / TM Owner

Abdi Farma Gmbh

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Indications & Clinical Uses

Nevirapin is indicated for treatment of HIV‑1 infection as part of combination antiretroviral therapy.

  • HIV‑1 infection: reduces viral load and improves immune function when used with other antiretroviral agents

How It Works

  • Nevirapine binds to a non‑nucleoside site on the HIV‑1 reverse transcriptase enzyme, inducing a conformational change that blocks the enzyme's RNA‑dependent DNA polymerase activity. This inhibition prevents the conversion of viral RNA into DNA, thereby halting viral replication and limiting the spread of infection within the host.

Side Effects

Nevirapin may cause a range of adverse reactions, which are generally categorized by frequency and severity.

Common Side Effects

  • Rash: mild to moderate skin eruption
  • Nausea: feeling of stomach upset
  • Fatigue: generalized tiredness
  • Headache: mild to moderate pain in the head
  • Dizziness: sensation of light‑headedness
  • Abdominal pain: discomfort in the stomach area
  • Elevated liver enzymes: mild increase in hepatic transaminases

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe skin reaction with blistering
  • Toxic epidermal necrolysis: extensive skin detachment
  • Severe hepatotoxicity: marked liver injury, jaundice, or hepatitis
  • Hypersensitivity reactions: systemic symptoms such as fever and organ involvement
  • Hemolytic anemia: destruction of red blood cells
  • Severe rash: extensive or bullous skin eruptions

Precautions & Warnings

Before initiating therapy, clinicians should assess patient history and monitor for potential risks.

  • Monitor liver function: obtain baseline and periodic liver‑function tests
  • Assess for hypersensitivity: discontinue if severe rash or systemic symptoms develop
  • Avoid in known nevirapine hypersensitivity: contraindicated in patients with prior reactions
  • Caution with hepatitis B or C: increased risk of liver injury
  • Pregnancy safety: risk unknown; weigh benefits against potential fetal harm
  • Store at room temperature: keep in original container, protect from moisture and heat

Avoid Interactions

Nevirapin can interact with several medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Potent CYP3A4 inducers (e.g., rifampicin): may markedly reduce nevirapine levels
  • Co‑administration with hepatotoxic drugs (e.g., isoniazid): increases risk of liver injury
  • Use with other NNRTIs: may lead to additive toxicity

Moderate Interactions (Monitor Closely)

  • Protease inhibitors: may require dose adjustment of nevirapine
  • Anticoagulants (e.g., warfarin): potential alteration of INR values
  • Hormonal contraceptives: may reduce contraceptive effectiveness, requiring additional methods

Frequently Asked Questions

Nevirapin contains the active ingredient nevirapine and is used as part of combination antiretroviral therapy to treat HIV‑1 infection in adults and children. It helps lower the viral load and supports immune system recovery when given with other approved HIV medicines.

Nevirapine binds to a specific non‑nucleoside site on the HIV‑1 reverse transcriptase enzyme. This binding causes a structural change that blocks the enzyme’s ability to copy viral RNA into DNA, thereby preventing the virus from replicating and spreading within the host.

The dosage of Nevirapin is individualized by the prescribing healthcare professional based on factors such as the patient’s age, weight, treatment history, and concomitant medications. Only a qualified prescriber can determine the appropriate regimen.

The safety of nevirapine in pregnancy and lactation has not been fully established. Clinicians must weigh the potential benefits for the mother against possible risks to the fetus or infant, and consider alternative options when appropriate.

To request Nevirapin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nevirapin (nevirapine) is one of several NNRTIs used in HIV therapy. Compared with alternatives such as efavirenz or rilpivirine, nevirapine has a distinct side‑effect profile, including a higher risk of skin reactions and liver enzyme elevations, while offering similar antiviral potency when combined with other agents.

Nevirapin should be stored at room temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture, direct sunlight, and excessive heat to maintain product stability throughout its shelf life.

Nevirapin is taken orally, usually as a tablet swallowed with water. The exact dosing schedule, including the number of tablets and timing relative to meals, is determined by the prescribing clinician and should be followed exactly as instructed.

Serious risks include severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, and potentially life‑threatening liver injury. Patients should be monitored closely for rash, jaundice, or other signs of hypersensitivity, and the drug should be stopped immediately if these occur.

Nevirapin is contraindicated in individuals with a known hypersensitivity to nevirapine or any component of the formulation. It should also be avoided in patients with severe liver disease or a history of severe skin reactions to NNRTIs, unless a specialist determines that benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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