Product image of Nevirapina Aurobindo (Nevirapine) supplied by GNH India

Nevirapina Aurobindo

Active Ingredient:
Nevirapine
Origin:
EU

Nevirapina Aurobindo (Nevirapine)

Nevirapine, the active ingredient in Nevirapina Aurobindo, is a non‑nucleoside reverse transcriptase inhibitor (NNRTI) presented as a tablet for oral use. It treats HIV‑1 infection in adults and children, helping to suppress viral replication.

GNH India supplies Nevirapina Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable access to antiretroviral therapy for qualified patients. The company adheres to stringent quality standards and offers global distribution to meet the needs of healthcare providers.

Manufacturer / TM Owner

Aurobindo Pharma (Italia) S.R.L.

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Indications & Clinical Uses

Nevirapine is indicated for HIV‑1 infection, targeting the viral replication pathway.

  • Adult HIV‑1 infection: Reduces viral load and improves immune function in treatment‑experienced or naïve adults.
  • Pediatric HIV‑1 infection (≥2 years): Provides viral suppression in children as part of combination antiretroviral therapy.
  • Prevention of mother‑to‑child transmission of HIV‑1: Used in pregnant women to lower the risk of vertical transmission.

How It Works

  • Nevirapine binds to a non‑nucleoside site on the HIV‑1 reverse transcriptase enzyme, inducing a conformational change that blocks the enzyme’s activity. This inhibition prevents the transcription of viral RNA into DNA, thereby halting the replication cycle of HIV and reducing the amount of virus circulating in the bloodstream.

Side Effects

Nevirapine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Rash: mild to moderate skin eruptions.
  • Nausea: occasional gastrointestinal upset.
  • Headache: transient cranial discomfort.
  • Fatigue: general tiredness.
  • Insomnia: difficulty sleeping.
  • Abdominal pain: mild stomach discomfort.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe skin reaction requiring immediate medical attention.
  • Toxic epidermal necrolysis: life‑threatening skin detachment.
  • Hepatic failure: marked liver enzyme elevation or liver injury.
  • Severe hypersensitivity: systemic allergic response.
  • Neutropenia: significant reduction in white blood cells.
  • Anemia: decreased red blood cell count.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Monitor liver function: baseline and periodic LFTs due to risk of hepatotoxicity.
  • Avoid use in patients with known hypersensitivity to nevirapine.
  • Do not initiate therapy in pregnant women unless benefits outweigh risks.
  • Assess for concomitant use with strong CYP3A4 inducers which may lower drug exposure.
  • Educate patients about rash and advise immediate medical evaluation if severe.
  • Store at ambient temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Nevirapine interacts with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Rifampicin: potent CYP3A4 inducer that markedly reduces nevirapine levels.
  • Ritonavir-boosted protease inhibitors: can cause unpredictable plasma concentrations.
  • St. John’s wort: herbal CYP3A4 inducer leading to subtherapeutic exposure.

Moderate Interactions (Monitor Closely)

  • Other antiretrovirals (e.g., efavirenz): may require dose adjustments.
  • Warfarin: nevirapine can alter anticoagulant effect, necessitating INR monitoring.
  • Oral contraceptives: efficacy may be reduced; consider alternative contraception.

Frequently Asked Questions

Nevirapina Aurobindo contains nevirapine, an antiretroviral medication used to treat HIV‑1 infection in adults and children. It is also employed in combination regimens to prevent mother‑to‑child transmission of HIV during pregnancy.

Nevirapine binds to a non‑nucleoside site on the HIV‑1 reverse transcriptase enzyme, causing a conformational change that blocks the enzyme’s activity. This prevents the conversion of viral RNA into DNA, halting viral replication and reducing viral load.

The dosing regimen for nevirapine is individualized and must be determined by a qualified prescriber based on the patient’s age, weight, treatment history, and co‑medications. Patients should follow the specific instructions provided by their healthcare professional.

Nevirapine’s safety in pregnancy is classified as unknown, and it should only be used when the potential benefits outweigh the risks. Breastfeeding while on nevirapine is generally not recommended unless the infant’s HIV status has been confirmed and the benefits of therapy are deemed essential.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Both nevirapine and efavirenz belong to the NNRTI class and suppress HIV replication by targeting reverse transcriptase. Nevirapine is often chosen for its lower central nervous system side‑effect profile, while efavirenz may have a higher risk of neuropsychiatric events. Selection depends on patient tolerance, drug‑interaction potential, and clinical guidelines.

Store the tablets at ambient temperature, preferably below 25 °C, in the original blister pack or container. Protect them from moisture, direct sunlight, and excessive heat to maintain potency throughout the shelf life.

Nevirapina Aurobindo is taken orally, usually with food to improve absorption and reduce gastrointestinal discomfort. The tablets should be swallowed whole with a full glass of water and not crushed or chewed unless specifically instructed by a healthcare professional.

The most serious adverse events include severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, and potentially life‑threatening hepatic failure. Early recognition of rash, jaundice, or flu‑like symptoms is essential, and patients should seek immediate medical attention if these occur.

Nevirapine is contraindicated in individuals with a known hypersensitivity to the drug or any of its components. It should also be avoided in patients with pre‑existing severe liver disease or those who have experienced severe rash or hepatic reactions to nevirapine in the past.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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