Product image of Nevirapină Accord (Nevirapine) supplied by GNH India

Nevirapină Accord

Active Ingredient:
Nevirapine
Origin:
EU

Nevirapină Accord (Nevirapine)

Nevirapine, the active ingredient in Nevirapină Accord, is a Non‑nucleoside reverse transcriptase inhibitor (NNRTI) presented as an oral tablet for oral use. It is used in the management of HIV‑1 infection in adults and adolescents.

GNH India supplies Nevirapină Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare S.L.U.

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Indications & Clinical Uses

Nevirapină Accord is a non‑nucleoside reverse transcriptase inhibitor indicated for HIV‑1 infection and related therapeutic strategies.

  • HIV‑1 infection (treatment): reduces viral replication when used as part of combination antiretroviral therapy.
  • Mother‑to‑child transmission prevention: administered to pregnant women to lower the risk of vertical HIV transmission.
  • Pediatric HIV‑1 infection (≥2 kg): used in combination regimens for children meeting weight criteria.

How It Works

  • Nevirapine binds to a non‑nucleoside site on the HIV‑1 reverse transcriptase enzyme, inducing a conformational change that impairs the enzyme’s ability to transcribe viral RNA into DNA. This inhibition blocks a critical step in the HIV replication cycle, decreasing viral load and slowing disease progression when combined with other antiretrovirals.

Side Effects

Nevirapină Accord may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Rash: mild to moderate skin eruption.
  • Nausea: occasional gastrointestinal discomfort.
  • Headache: transient cranial pain.
  • Fatigue: general feeling of tiredness.
  • Diarrhea: loose stools, usually self‑limiting.
  • Elevated liver enzymes: mild increase in hepatic transaminases.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe mucocutaneous reaction requiring immediate medical attention.
  • Hepatotoxicity: significant liver injury, potentially leading to jaundice or hepatitis.
  • Severe rash or hypersensitivity: may progress to toxic epidermal necrolysis.
  • Hematologic abnormalities: rare cases of anemia or neutropenia.

Precautions & Warnings

Before initiating therapy with Nevirapină Accord, consider the following precautions.

  • Hepatic monitoring: assess liver function tests prior to start and periodically during treatment.
  • Dermatologic assessment: examine skin for rash; discontinue if severe.
  • Drug resistance: avoid monotherapy to prevent emergence of resistant HIV strains.
  • Pregnancy considerations: evaluate risk‑benefit ratio; consult specialist.
  • Breastfeeding: discuss potential infant exposure with healthcare provider.
  • Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture and direct sunlight.

Avoid Interactions

Nevirapină Accord can interact with several medications, affecting efficacy or safety.

Major Interactions (Avoid)

  • Rifampicin: induces metabolism, markedly reducing nevirapine levels.
  • St. John’s wort: strong enzyme inducer, may lower drug exposure.
  • Protease inhibitors (e.g., ritonavir): can increase nevirapine concentrations, raising toxicity risk.

Moderate Interactions (Monitor Closely)

  • Azole antifungals (e.g., ketoconazole): may increase nevirapine levels modestly.
  • Warfarin: potential alteration of anticoagulant effect; monitor INR.
  • Oral contraceptives: nevirapine may reduce hormonal efficacy; advise additional contraceptive measures.

Frequently Asked Questions

Nevirapină Accord contains nevirapine, an antiretroviral medication used to treat HIV‑1 infection. It is prescribed as part of combination therapy to suppress viral replication in adults, adolescents, and eligible children, and may also be used to reduce the risk of mother‑to‑child transmission during pregnancy.

Nevirapine belongs to the non‑nucleoside reverse transcriptase inhibitor (NNRTI) class. It binds to a specific non‑nucleoside site on the HIV‑1 reverse transcriptase enzyme, causing a structural change that blocks the enzyme’s ability to convert viral RNA into DNA, thereby interrupting the HIV replication cycle.

The dosage of Nevirapină Accord is individualized by the prescribing clinician based on factors such as the patient’s age, weight, treatment history, and co‑administered medications. Healthcare providers determine the appropriate regimen and monitor response and safety throughout therapy.

Nevirapină Accord may be prescribed during pregnancy when the benefits outweigh potential risks, particularly to prevent vertical transmission of HIV. However, safety data are limited, and clinicians should assess each case. Breastfeeding while on nevirapine should be discussed with a specialist due to possible infant exposure.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nevirapină Accord (nevirapine) is an NNRTI, differing from protease inhibitors and integrase strand transfer inhibitors in its mechanism of action. Compared with efavirenz, another NNRTI, nevirapine has a lower incidence of central nervous system side effects but a higher risk of rash and hepatotoxicity, influencing clinician choice based on patient profile.

Nevirapină Accord should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in their original container, protect them from moisture, heat, and direct sunlight to maintain stability throughout the shelf life.

Nevirapină Accord is taken orally, usually with food to improve tolerability. The tablets are swallowed whole with a full glass of water. Administration timing and frequency are determined by the prescribing clinician as part of the overall antiretroviral regimen.

The most serious risks include severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, and significant liver injury leading to hepatitis or hepatic failure. Prompt medical evaluation is essential if symptoms like extensive rash, jaundice, or unexplained fatigue develop.

Nevirapină Accord is contraindicated in patients with known hypersensitivity to nevirapine or any component of the formulation. It should also be avoided in individuals with pre‑existing severe hepatic impairment or a history of severe rash to NNRTIs, unless a specialist determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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