Product image of Nevirapine Aurobindo (Nevirapine) supplied by GNH India

Nevirapine Aurobindo

Active Ingredient:
Nevirapine
Origin:
EU

Nevirapine Aurobindo (Nevirapine)

Nevirapine, the active ingredient in Nevirapine Aurobindo, is a non‑nucleoside reverse transcriptase inhibitor (NNRTI) presented as a tablet for oral use. It is used in the treatment of HIV‑1 infection in adults and adolescents. GNH India supplies Nevirapine Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aurobindo Pharma B.V.

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Indications & Clinical Uses

Nevirapine is an antiretroviral medication that targets the HIV‑1 reverse transcriptase pathway.

  • HIV‑1 infection: reduces viral replication and helps restore immune function in infected individuals.

How It Works

  • Nevirapine binds to a non‑nucleoside site on the HIV‑1 reverse transcriptase enzyme, inducing a conformational change that inhibits the enzyme’s activity. This prevents the transcription of viral RNA into DNA, thereby blocking the replication cycle of HIV and reducing viral load in the patient.

Side Effects

Nevirapine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Rash: mild to moderate skin eruptions.
  • Nausea: occasional upset stomach.
  • Headache: transient cranial discomfort.
  • Fatigue: general tiredness.
  • Diarrhea: loose stools.
  • Elevated liver enzymes: mild hepatic enzyme rise.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe skin reaction requiring immediate medical attention.
  • Hepatotoxicity: significant liver injury, potentially leading to jaundice.
  • Severe rash: extensive skin involvement.
  • Hypersensitivity reactions: including fever and eosinophilia.
  • Hematologic abnormalities: such as neutropenia or anemia.
  • Pancreatitis: inflammation of the pancreas.

Precautions & Warnings

When prescribing Nevirapine, clinicians should consider several safety measures.

  • Liver function monitoring: assess baseline and periodic liver enzymes.
  • Skin assessment: watch for rash or signs of severe cutaneous reactions.
  • Pregnancy considerations: evaluate risks versus benefits before use.
  • Drug interactions: review concomitant medications for potential interactions.
  • Adherence counseling: emphasize importance of consistent dosing.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nevirapine can affect the metabolism of other drugs, requiring careful review.

Major Interactions (Avoid)

  • Rifampicin: may reduce nevirapine plasma levels, compromising efficacy.
  • St. John’s wort: induces metabolism, lowering drug exposure.
  • Protease inhibitors (e.g., ritonavir): can increase nevirapine concentrations, raising toxicity risk.

Moderate Interactions (Monitor Closely)

  • Warfarin: may alter anticoagulant effect, monitor INR.
  • Oral contraceptives: reduced effectiveness, consider alternative contraception.
  • Efavirenz: combined use may increase hepatotoxicity risk.
  • Fluconazole: may increase nevirapine levels, monitor liver function.

Frequently Asked Questions

Nevirapine Aurobindo is an antiretroviral medication indicated for the treatment of HIV‑1 infection in adults and adolescents. It works as part of combination therapy to suppress viral replication and improve immune function.

Nevirapine inhibits the HIV‑1 reverse transcriptase enzyme by binding to a non‑nucleoside site, causing a conformational change that blocks the conversion of viral RNA into DNA. This interruption of the replication cycle reduces viral load.

The dosage of Nevirapine Aurobindo is determined by the prescribing clinician based on individual patient factors, treatment guidelines, and combination regimen. Patients should follow the exact dosing instructions provided by their healthcare professional.

The safety of Nevirapine in pregnancy and lactation is not fully established. Clinicians must weigh potential benefits against risks and consider alternative therapies when appropriate. Breastfeeding decisions should be made in consultation with a healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nevirapine belongs to the NNRTI class, which directly inhibits reverse transcriptase at a non‑nucleoside site. Compared with nucleoside reverse transcriptase inhibitors (NRTIs), NNRTIs like Nevirapine often have a different resistance profile and may be combined with NRTIs for synergistic viral suppression.

Nevirapine Aurobindo tablets should be stored at ambient temperature, below 25 °C, in their original packaging. Protect the product from moisture, excessive heat and direct sunlight to maintain stability.

Nevirapine Aurobindo is taken orally, usually with food to reduce gastrointestinal irritation. The tablets should be swallowed whole with a full glass of water and not chewed or crushed unless specifically instructed by a healthcare professional.

Serious risks include severe skin reactions such as Stevens‑Johnson syndrome, hepatotoxicity leading to liver failure, and hypersensitivity reactions. Patients should be monitored closely for rash, jaundice, fever or other signs of liver injury, and seek immediate medical attention if they occur.

Nevirapine Aurobindo is contraindicated in individuals with a known hypersensitivity to nevirapine or any component of the formulation. It should also be avoided in patients with severe liver disease or a history of severe cutaneous adverse reactions to NNRTIs.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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