Product image of Nevolat (Liraglutide) supplied by GNH India

Nevolat

Active Ingredient:
Liraglutide
Origin:
EU

Nevolat (Liraglutide)

Liraglutide, the active ingredient in Nevolat, is a GLP-1 receptor agonist presented as a subcutaneous injection for subcutaneous use. It is indicated for the treatment of type 2 diabetes mellitus and for chronic weight management in adults.

GNH India supplies Nevolat as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product conforms to EU quality standards, is manufactured under strict GMP conditions, and our distribution network ensures timely delivery and regulatory compliance across multiple regions.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Liraglutide is a GLP-1 receptor agonist used in metabolic disorders.

  • Type 2 diabetes mellitus: improves glycaemic control by enhancing insulin secretion and lowering glucagon.
  • Obesity (chronic weight management): promotes sustained weight loss through appetite reduction.
  • Cardiovascular risk reduction in T2DM with established CVD: lowers incidence of major adverse cardiovascular events.

How It Works

  • Liraglutide mimics endogenous glucagon-like peptide‑1 (GLP‑1) and binds to the GLP‑1 receptor on pancreatic β‑cells, enhancing glucose‑dependent insulin secretion while suppressing glucagon release. It also slows gastric emptying and acts on hypothalamic pathways to reduce appetite, collectively improving glycaemic control and supporting weight loss.

Side Effects

Liraglutide may cause a range of adverse reactions, which are grouped by frequency.

Common Side Effects

  • Nausea
  • Vomiting
  • Diarrhoea
  • Constipation
  • Headache
  • Injection‑site reactions

Serious or Rare Side Effects

  • Pancreatitis
  • Gallbladder disease (cholelithiasis, cholecystitis)
  • Severe hypoglycaemia (especially with insulin or sulfonylureas)
  • Thyroid C‑cell tumours (observed in rodent studies)
  • Anaphylactic reactions
  • Acute renal impairment

Precautions & Warnings

When prescribing liraglutide, clinicians should consider several safety precautions.

  • Renal function: monitor in patients with moderate to severe renal impairment.
  • Thyroid disease: avoid in individuals with a personal or family history of medullary thyroid carcinoma or MEN 2.
  • Pancreatitis: discontinue if signs or symptoms of pancreatitis develop.
  • Pregnancy and lactation: safety not established; use only if potential benefit justifies risk.
  • Drug interactions: review concomitant medications for hypoglycaemia risk.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Liraglutide can affect the activity of other medicines; some combinations require avoidance while others need monitoring.

Major Interactions (Avoid)

  • Insulin: increased risk of severe hypoglycaemia.
  • Sulfonylureas: heightened hypoglycaemia potential.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible alteration of INR values.
  • Oral contraceptives: may reduce hormonal efficacy.
  • Other GLP‑1 receptor agonists: additive effects on gastrointestinal tolerance.

Frequently Asked Questions

Nevolat contains liraglutide, a GLP‑1 receptor agonist indicated for improving blood glucose control in adults with type 2 diabetes mellitus and for chronic weight management in individuals with obesity. It may also be prescribed to reduce cardiovascular risk in patients with type 2 diabetes and established cardiovascular disease.

Liraglutide binds to the GLP‑1 receptor on pancreatic beta cells, enhancing insulin secretion only when glucose levels are elevated. It simultaneously suppresses glucagon release, slows gastric emptying, and acts on brain centres that regulate appetite, leading to lower post‑prandial glucose excursions and reduced caloric intake.

The dosing regimen for Nevolat is individualized by the prescribing healthcare professional. Typically, treatment starts with a low dose that is gradually increased based on therapeutic response and tolerability, but the exact amount and titration schedule must be determined by the prescriber.

Safety of liraglutide during pregnancy and lactation has not been established. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To request Nevolat, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Nevolat (liraglutide) shares the core mechanism of GLP‑1 receptor activation with other agents in its class, but it differs in dosing frequency, molecular size and specific trial data. For example, some GLP‑1 agonists are weekly injections, whereas liraglutide is administered daily, offering more flexible titration but requiring more frequent administration.

Nevolat must be stored at 2‑8 °C (refrigerated) in its original carton, protected from light. Do not freeze or shake the vial. If the product has been kept at room temperature for more than a few hours, it should be discarded according to the supplier’s stability guidelines.

Nevolat is supplied as a sterile solution for subcutaneous injection. It is typically injected into the abdomen, thigh or upper arm using a pre‑filled pen or syringe, following the injection technique taught by a healthcare professional. The injection site should be rotated to minimise local reactions.

Serious adverse events associated with liraglutide include pancreatitis, gallbladder disease, severe hypoglycaemia (especially when combined with insulin or sulfonylureas), and rare thyroid C‑cell tumours observed in animal studies. Patients should be instructed to seek immediate medical attention if they experience persistent abdominal pain, vomiting, or signs of an allergic reaction.

Nevolat is contraindicated in individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2, and in patients with known hypersensitivity to liraglutide or any excipients. Caution is also advised for those with severe renal impairment, active pancreatitis, or uncontrolled thyroid disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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