Product image of Nevotens (Nebivolol Hydrochloride) supplied by GNH India

Nevotens

Active Ingredient:
Nebivolol Hydrochloride
Origin:
EU

Nevotens (Nebivolol Hydrochloride)

Nebivolol Hydrochloride, the active ingredient in Nevotens, is a beta‑blocker presented as an oral tablet for oral use. It belongs to the class of selective β1‑adrenergic receptor antagonists with nitric‑oxide mediated vasodilation and is prescribed to manage hypertension and heart failure in adult patients.

GNH India supplies Nevotens as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide, providing reliable sourcing and regulatory‑aligned distribution for global markets. All batches are manufactured under stringent GMP standards to ensure product consistency.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Nebivolol is used in cardiovascular therapy to lower blood pressure and improve heart function, particularly in conditions where β‑blockade is beneficial.

  • Hypertension: reduces systolic and diastolic blood pressure, helping to prevent cardiovascular complications.
  • Heart failure: improves left ventricular ejection fraction and reduces symptoms of chronic heart failure.
  • Post‑myocardial infarction: may help lower the risk of recurrent cardiac events.

How It Works

  • Nebivolol selectively blocks β1‑adrenergic receptors in cardiac tissue, decreasing heart rate and contractility, which lowers myocardial oxygen demand. In addition, it stimulates endothelial nitric‑oxide synthase, leading to nitric‑oxide release and vasodilation of peripheral vessels. This combined β‑blockade and nitric‑oxide mediated vasodilation results in reduced systemic vascular resistance and blood pressure. The drug’s high β1 selectivity minimizes effects on β2 receptors in the lungs, reducing the risk of bronchoconstriction.

Side Effects

Nebivolol may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Fatigue
  • Headache
  • Dizziness
  • Nausea

Serious or Rare Side Effects

  • Severe bradycardia
  • Symptomatic hypotension
  • Bronchospasm

Precautions & Warnings

When prescribing Nebivolol, clinicians should consider several safety measures.

  • Monitor blood pressure: check regularly to ensure therapeutic response.
  • Assess heart rate: watch for excessive bradycardia, especially in patients with conduction disorders.
  • Use caution in asthma or COPD: β‑blockade may exacerbate bronchospasm.
  • Avoid abrupt discontinuation: taper dose to prevent rebound hypertension.
  • Adjust dose in renal impairment: consider reduced dosing in patients with decreased renal function.
  • Store at room temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Nebivolol can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Concomitant use with other β‑blockers: may cause additive bradycardia.
  • Calcium channel blockers verapamil or diltiazem: increase plasma levels and risk of heart block.
  • Strong CYP2D6 inhibitors (paroxetine, fluoxetine): raise nebivolol concentrations, leading to hypotension.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance antihypertensive effect, monitor electrolytes.
  • NSAIDs: can reduce antihypertensive efficacy, check blood pressure.
  • Anti‑arrhythmic agents (e.g., amiodarone): may affect cardiac conduction.

Frequently Asked Questions

Nevotens contains nebivolol hydrochloride, which is prescribed to treat high blood pressure (hypertension) and to manage chronic heart failure. By lowering systemic vascular resistance and improving cardiac output, it helps reduce the risk of cardiovascular complications associated with these conditions.

Nebivolol selectively blocks β1‑adrenergic receptors in the heart, decreasing heart rate and contractility. It also stimulates endothelial nitric‑oxide synthase, causing nitric‑oxide release that dilates peripheral blood vessels. This dual action lowers blood pressure and reduces cardiac workload.

The appropriate dose of Nevotens is determined by a qualified prescriber based on the individual’s clinical condition, age, renal function and response to therapy. Typical dosing ranges are described in the prescribing information, but the exact regimen should be set by the treating physician.

Safety data for nebivolol during pregnancy and lactation are limited. The product is classified as a pregnancy category unknown, and use is generally avoided unless the potential benefit justifies the potential risk to the fetus. Breastfeeding mothers should consult their healthcare provider before use.

To request Nevotens, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will verify trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Nevotens (nebivolol) is a highly selective β1‑blocker that also promotes nitric‑oxide mediated vasodilation, offering a favorable profile for blood‑pressure reduction with fewer bronchoconstrictive effects compared with non‑selective beta‑blockers. This dual mechanism can provide better tolerability in some patients.

Nevotens tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Nevotens is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the prescriber’s instructions regarding timing and whether the dose should be taken in the morning or evening.

Serious adverse reactions to Nevotens include severe bradycardia, symptomatic hypotension and bronchospasm, especially in patients with pre‑existing respiratory disease. Prompt medical attention is required if these symptoms occur.

Nevotens should be avoided in patients with known hypersensitivity to nebivolol or any excipients, in those with severe bradycardia, second‑ or third‑degree heart block without a pacemaker, and in individuals with uncompensated heart failure or severe hepatic impairment unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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