Product image of Nevralgio (Paracetamol, Acetylsalicylic Acid, Caffeine) supplied by GNH India

Nevralgio

Active Ingredient:
Paracetamol, Acetylsalicylic Acid, Caffeine
Origin:
EU

Nevralgio (Paracetamol, Acetylsalicylic Acid, Caffeine)

Paracetamol, Acetylsalicylic Acid and Caffeine, the active ingredients in Nevralgio, form an analgesic and antipyretic combination presented as an oral tablet for oral use. The product is intended to relieve mild to moderate pain and reduce fever in adults and adolescents.

GNH India supplies Nevralgio as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to European Union quality standards and provides reliable global distribution.

Manufacturer / TM Owner

Sc Sintofarm Sa

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Indications & Clinical Uses

Nevralgio is used to manage pain and fever by acting on prostaglandin pathways.

  • Headache: provides rapid relief of tension‑type and mild migraine pain.
  • Fever: reduces elevated body temperature in febrile conditions.
  • Mild to moderate pain: alleviates dental, musculoskeletal, and postoperative discomfort.

How It Works

  • Paracetamol inhibits central cyclooxygenase activity, lowering prostaglandin synthesis in the brain, which reduces pain perception and fever. Acetylsalicylic acid irreversibly blocks COX‑1 and COX‑2 enzymes in peripheral tissues, decreasing prostaglandin‑mediated inflammation and pain. Caffeine antagonizes adenosine receptors, producing a mild stimulant effect and enhancing the analgesic potency of the other two agents, resulting in a synergistic combination for effective symptom control.

Side Effects

Like all medicines, Nevralgio may cause unwanted reactions.

Common Side Effects

  • Nausea: mild stomach upset.
  • Gastric irritation: discomfort or heartburn.
  • Insomnia: difficulty sleeping due to caffeine.
  • Increased heart rate: mild palpitations.

Serious or Rare Side Effects

  • Gastrointestinal bleeding: black stools or vomiting blood.
  • Allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Liver toxicity: jaundice or elevated liver enzymes with excessive use.

Precautions & Warnings

Before using Nevralgio, consider the following safety measures.

  • Assess liver function: avoid use in patients with severe hepatic impairment.
  • Evaluate bleeding risk: caution in individuals with ulcers, anticoagulant therapy, or clotting disorders.
  • Monitor caffeine intake: limit additional stimulants to reduce insomnia or tachycardia.
  • Avoid use in children under 12 years: safety not established for this age group.
  • Pregnancy and breastfeeding: consult a healthcare professional as safety data are limited.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Nevralgio can interact with other medicines; awareness of key interactions helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin‑containing products: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency.

Moderate Interactions (Monitor Closely)

  • Diuretics: caffeine may reduce diuretic effectiveness.
  • Antihypertensives: caffeine can counteract blood‑pressure‑lowering effects.
  • Methotrexate: aspirin may decrease renal clearance, raising toxicity risk.

Frequently Asked Questions

Nevralgio is an oral combination of paracetamol, acetylsalicylic acid and caffeine indicated for the relief of mild to moderate pain such as headache, dental or musculoskeletal discomfort, and for the reduction of fever in adults and adolescents.

Paracetamol reduces central prostaglandin synthesis, aspirin irreversibly blocks peripheral COX‑1 and COX‑2 enzymes, and caffeine blocks adenosine receptors while stimulating the central nervous system. Together they provide synergistic analgesic and antipyretic effects, with caffeine enhancing the pain‑relieving action of the other two agents.

The appropriate dose of Nevralgio is determined by a qualified prescriber based on the individual’s age, weight, medical condition and response to therapy. Patients should follow the dosing instructions provided on the prescription label and not exceed the recommended amount.

Safety data for Nevralgio in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their healthcare professional before using this product to weigh potential benefits against possible risks.

To order Nevralgio, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Nevralgio combines three agents, offering faster pain relief and enhanced fever reduction compared with single‑ingredient paracetamol. Unlike ibuprofen, it contains aspirin, which provides antiplatelet activity but may increase gastrointestinal risk. The caffeine component further augments analgesia, making Nevralgio useful when a stronger, multimodal effect is desired.

Nevralgio tablets should be stored at ambient temperature, preferably below 25 °C, in their original blister pack or container. Keep the product away from moisture, direct sunlight and heat sources to maintain stability and potency throughout its shelf life.

Nevralgio is taken orally with a full glass of water. It can be taken with or without food, although taking it with food may reduce the likelihood of gastric irritation. Swallow the tablet whole; do not crush or chew unless specifically instructed by a healthcare professional.

The most serious risks include gastrointestinal bleeding, especially in patients with ulcer disease or on anticoagulants; severe allergic reactions such as anaphylaxis; and liver toxicity if the product is taken in excess or combined with other hepatotoxic agents. Prompt medical attention is required if any of these symptoms occur.

Nevralgio should be avoided by individuals with known hypersensitivity to paracetamol, aspirin, caffeine or any excipients, children under 12 years of age, patients with active peptic ulcer disease, severe liver impairment, bleeding disorders, or those taking anticoagulant therapy unless directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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