Product image of Nevrine Codeine (Paracetamol, Caffeine, Codeine Phosphate Hemihydrate) supplied by GNH India

Nevrine Codeine

Active Ingredient:
Paracetamol, Caffeine, Codeine Phosphate Hemihydrate
Origin:
EU

Nevrine Codeine (Paracetamol, Caffeine, Codeine Phosphate Hemihydrate)

Paracetamol / Caffeine / Codeine phosphate hemihydrate, the active ingredient in Nevrine Codeine, is an analgesic presented as an oral tablet for oral use. It provides pain relief and fever reduction for adults with mild to moderate pain.
GNH India supplies Nevrine Codeine as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoires Sterop

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Nevrine Codeine combines analgesic and antipyretic agents to treat pain and fever.
  • Mild to moderate pain: reduces discomfort from tension, musculoskeletal or dental sources.
  • Headache: alleviates tension‑type and migraine‑associated headache.
  • Fever: lowers elevated body temperature in febrile conditions.

How It Works

  • Paracetamol centrally inhibits COX enzymes, decreasing prostaglandin synthesis; caffeine antagonizes adenosine receptors, enhancing analgesic perception; codeine phosphate hemihydrate is metabolised to morphine, which activates µ‑opioid receptors to produce analgesia and cough suppression.

Side Effects

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Constipation: reduced bowel movements.
  • Drowsiness: increased sleepiness.
  • Dizziness: sensation of light‑headedness.
  • Dry mouth: reduced salivation.
  • Insomnia: difficulty falling asleep, often from caffeine.

Serious or Rare Side Effects

  • Respiratory depression: slowed breathing, especially in opioid‑naïve individuals.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Hepatotoxicity: potential liver injury with high paracetamol exposure.
  • Dependence or addiction: risk with prolonged codeine use.
  • Seizures: rare but possible neurological event.
  • Low blood pressure: hypotension in susceptible patients.

Precautions & Warnings

  • Precautions should be observed before prescribing Nevrine Codeine.
  • Assess liver function: avoid in severe hepatic impairment.
  • Monitor for respiratory depression: especially in opioid‑naïve patients.
  • Avoid concomitant CNS depressants: may increase sedation.
  • Use caution in pregnancy: risk assessment required.
  • Avoid in children under 12 years: not recommended for this age group.
  • Store at ambient temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Nevrine Codeine may interact with several medicines.

Major Interactions (Avoid)

  • Other opioids: additive respiratory depression.
  • Benzodiazepines or barbiturates: increased CNS depression.
  • Alcohol: heightened sedation and respiratory risk.
  • Monoamine oxidase inhibitors (MAOIs): risk of serotonin syndrome.
  • CYP2D6 inhibitors (e.g., fluoxetine): may reduce codeine conversion.

Moderate Interactions (Monitor Closely)

  • CYP1A2 inducers (e.g., rifampicin): may reduce caffeine effect.
  • Anticoagulants (warfarin): may increase bleeding risk.
  • Diuretics: may enhance hypotensive effect.

Frequently Asked Questions

Nevrine Codeine is an oral combination product containing paracetamol, caffeine and codeine phosphate hemihydrate. It is used to relieve mild to moderate pain, treat headache and reduce fever in adult patients.

Paracetamol reduces prostaglandin synthesis by inhibiting central COX enzymes, caffeine blocks adenosine receptors to boost alertness and analgesia, and codeine is converted to morphine, which activates µ‑opioid receptors to provide pain relief and cough suppression.

The dose of Nevrine Codeine is determined by the prescribing clinician based on the patient’s condition, age, weight and other medications. The prescriber will set the appropriate strength and frequency.

Safety in pregnancy and lactation has not been fully established. Use only if the potential benefit justifies the potential risk to the fetus or infant, and discuss with a healthcare professional before starting therapy.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with single‑ingredient paracetamol products, Nevrine Codeine adds caffeine to enhance analgesia and codeine for opioid‑mediated pain control, offering stronger relief for moderate pain. It differs from pure opioid preparations by also providing antipyretic and stimulant effects.

Nevrine Codeine tablets should be stored at ambient temperature, below 25 °C, in the original container, protected from moisture and direct sunlight. Keep out of reach of children.

The product is taken orally, usually with a full glass of water. It may be taken with or without food, but patients should follow the prescriber’s instructions regarding timing and any food considerations.

Serious risks include respiratory depression, severe allergic reactions, hepatotoxicity from excessive paracetamol, and the potential for dependence or addiction with prolonged codeine use. Patients should seek immediate medical attention if they experience difficulty breathing, rash, or unusual fatigue.

Nevrine Codeine should be avoided in children under 12 years, patients with severe liver disease, known hypersensitivity to any component, those taking MAO inhibitors, and individuals with a history of opioid dependence unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Paracetamol, Caffeine, Codeine Phosphate Hemihydrate

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT