Product image of Nevropram (Citalopram Hydrobromide) supplied by GNH India

Nevropram

Active Ingredient:
Citalopram Hydrobromide
Origin:
EU

Nevropram (Citalopram Hydrobromide)

Citalopram hydrobromide, the active ingredient in Nevropram, is a selective serotonin reuptake inhibitor (SSRI) presented as an oral tablet for oral use. It is indicated for the treatment of major depressive disorder and related anxiety conditions in adult patients.

GNH India supplies Nevropram as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand. Customers benefit from reliable logistics, comprehensive documentation, and responsive technical support throughout the procurement process.

Manufacturer / TM Owner

Viofar Ltd

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Indications & Clinical Uses

Nevropram (citalopram hydrobromide) acts on the serotonergic pathway and is prescribed for several mood and anxiety disorders.

  • Major depressive disorder: reduces depressive symptoms and improves mood.
  • Obsessive‑compulsive disorder: lessens intrusive thoughts and compulsive behaviors.
  • Panic disorder: decreases frequency and intensity of panic attacks.
  • Social anxiety disorder: alleviates fear of social situations and improves functioning.

How It Works

  • Citalopram hydrobromide selectively inhibits the serotonin transporter (SERT) on presynaptic neurons, blocking reuptake of serotonin from the synaptic cleft. This raises extracellular serotonin concentrations, enhancing serotonergic neurotransmission throughout the central nervous system. The increased serotonin activity is linked to mood elevation, reduced anxiety, and modulation of emotional processing, which underlies its therapeutic effects in depressive and anxiety disorders.

Side Effects

Citalopram may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Headache: transient cranial discomfort.
  • Sexual dysfunction: decreased libido or delayed orgasm.

Serious or Rare Side Effects

  • Serotonin syndrome: agitation, hyperthermia, muscle rigidity.
  • Suicidal thoughts: emergence of suicidal ideation, especially early in treatment.
  • QT interval prolongation: cardiac rhythm disturbances.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Psychiatric assessment: evaluate baseline mood and suicidal risk before starting treatment.
  • Concomitant MAOI use: avoid co‑administration and maintain a minimum 14‑day washout period.
  • Hepatic impairment: adjust dose or monitor closely in patients with liver dysfunction.
  • Elderly patients: start at lower dose and monitor for hyponatremia.
  • Pregnancy and lactation: use only if potential benefit justifies potential risk.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Citalopram can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of serotonin syndrome; must not be combined.
  • Pimozide: can cause serious cardiac effects when used together.
  • Other serotonergic agents (e.g., tramadol, linezolid): increase risk of serotonin syndrome.

Moderate Interactions (Monitor Closely)

  • NSAIDs or anticoagulants: may elevate bleeding risk.
  • CYP2C19 inhibitors (e.g., fluoxetine, omeprazole): can raise citalopram plasma levels.
  • Alcohol: may enhance central nervous system depression.
  • Antihistamines with anticholinergic properties: may worsen dry mouth.

Frequently Asked Questions

Nevropram, containing citalopram hydrobromide, is prescribed for major depressive disorder and several anxiety‑related conditions, including obsessive‑compulsive disorder, panic disorder, and social anxiety disorder. These indications are based on its ability to enhance serotonergic neurotransmission, which helps improve mood and reduce anxiety symptoms in adult patients.

Citalopram hydrobromide selectively blocks the serotonin transporter (SERT) on presynaptic neurons, preventing reuptake of serotonin from the synaptic cleft. By increasing extracellular serotonin levels, it amplifies serotonergic signaling throughout the brain, which contributes to mood elevation and anxiety reduction in the conditions for which it is prescribed.

The appropriate dose of Nevropram is individualized by the prescribing healthcare professional. Factors such as the patient’s age, severity of symptoms, liver function, and concomitant medications influence the selected dosage. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Citalopram’s pregnancy category is listed as unknown, and safety data are limited. Clinicians weigh potential benefits against possible risks before prescribing to pregnant or nursing women. If treatment is deemed necessary, the prescriber will monitor both mother and infant closely and discuss any concerns with the patient.

To request Nevropram, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Nevropram (citalopram) is a highly selective SSRI with a relatively favorable side‑effect profile compared with some older agents. It has a lower affinity for other neurotransmitter receptors, which may reduce certain adverse effects such as weight gain. However, individual response varies, and clinicians choose an SSRI based on efficacy, tolerability, drug‑interaction potential, and patient history.

Nevropram tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and avoid exposing it to excessive heat or humidity, which could affect tablet integrity.

Nevropram is taken orally, usually as a tablet swallowed whole with water. It can be taken with or without food, but patients should follow the prescriber’s guidance on timing and whether to maintain a consistent routine to help achieve stable blood levels.

The most serious risks include serotonin syndrome (characterized by agitation, fever, muscle rigidity), emergence of suicidal thoughts especially during early treatment, and cardiac effects such as QT‑interval prolongation. Patients should seek immediate medical attention if they experience any of these symptoms.

Nevropram should be avoided in individuals currently taking monoamine oxidase inhibitors (MAOIs) or those who have taken an MAOI within the past 14 days. Patients with known hypersensitivity to citalopram or any component of the tablet, as well as those with certain cardiac conditions that predispose to QT prolongation, should not use this medication without specialist advice.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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