Product image of Nexag (Tranexamic Acid) supplied by GNH India

Nexag

Active Ingredient:
Tranexamic Acid
Origin:
EU

Nexag (Tranexamic Acid)

Tranexamic Acid, the active ingredient in Nexag, is an antifibrinolytic presented as an oral formulation for systemic use. It helps reduce excessive bleeding in conditions such as heavy menstrual bleeding, trauma‑related bleeding and surgical bleeding.

GNH India supplies Nexag as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Cemag Care

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Indications & Clinical Uses

Nexag, an antifibrinolytic, is employed to control bleeding in several clinical settings.

  • Heavy menstrual bleeding: reduces menstrual blood loss and improves quality of life.
  • Trauma‑related bleeding: stabilises clot formation after injury to limit blood loss.
  • Surgical bleeding: minimizes intra‑operative and post‑operative hemorrhage, supporting faster recovery.

How It Works

  • Tranexamic acid competitively inhibits the activation of plasminogen to plasmin by binding to lysine‑binding sites on plasminogen molecules. This blockade reduces fibrinolysis, preserving fibrin clot integrity and thereby decreasing bleeding in tissues where clot formation is required.

Side Effects

Tranexamic acid is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools occurring during treatment.
  • Headache: transient cranial discomfort.
  • Dizziness: occasional light‑headed sensation.

Serious or Rare Side Effects

  • Thromboembolic events: formation of clots in veins or arteries.
  • Hypersensitivity reactions: rash, itching, or anaphylaxis.
  • Visual disturbances: blurred vision or retinal changes.
  • Renal impairment: reduced kidney function in susceptible patients.

Precautions & Warnings

Before prescribing Nexag, clinicians should consider several safety measures.

  • Assess bleeding risk: evaluate patient history for coagulopathies.
  • Monitor renal function: adjust use in patients with impaired kidneys.
  • Review concomitant anticoagulants: avoid additive bleeding risk.
  • Use with caution in thrombosis history: consider alternative therapy.
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
  • Store at ambient temperature: keep in original pack, protect from moisture.

Avoid Interactions

Tranexamic acid may interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Procoagulant agents (e.g., activated factor VII): may increase clotting risk.
  • Combined use with other antifibrinolytics (e.g., aprotinin): excessive inhibition of fibrinolysis.
  • Hormonal contraceptives containing estrogen: heightened thrombosis potential.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may counteract hemostatic benefit.
  • Antiplatelet agents (e.g., aspirin, clopidogrel): monitor for bleeding.
  • Warfarin: possible alteration of INR values.
  • SSRIs or SNRIs: increased bleeding tendency, require observation.

Frequently Asked Questions

Nexag contains tranexamic acid and is prescribed to reduce excessive bleeding. It is indicated for heavy menstrual bleeding, bleeding associated with trauma, and surgical bleeding where stabilising clot formation is essential.

Tranexamic acid blocks the conversion of plasminogen to plasmin by binding to lysine‑binding sites. This inhibition reduces fibrinolysis, allowing formed clots to remain intact and effectively control bleeding.

The dosage of Nexag is determined by the prescribing clinician based on the specific indication, patient weight, renal function and overall clinical assessment. Patients should follow the exact regimen provided by their healthcare professional.

Safety data for tranexamic acid during pregnancy and lactation are limited. Healthcare providers should weigh potential benefits against risks and consider alternative therapies when appropriate. Consultation with a specialist is advised.

To order Nexag, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative to tranexamic acid is epsilon‑aminocaproic acid, another antifibrinolytic. Tranexamic acid generally offers a more potent inhibition of plasmin formation, allowing lower dosing and a more predictable safety profile, while epsilon‑aminocaproic acid may require higher doses for comparable effect.

Nexag should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing in areas with high humidity.

Nexag is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless directed by a healthcare professional. Dosing intervals are set by the prescriber.

Serious risks include the development of thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, severe hypersensitivity reactions including anaphylaxis, visual disturbances, and renal impairment. Patients should seek immediate medical attention if they experience symptoms suggestive of these conditions.

Nexag is contraindicated in individuals with known hypersensitivity to tranexamic acid, active intravascular clotting disorders, or those who have experienced previous thromboembolic events without appropriate medical supervision. It should also be used cautiously in patients with severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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