Product image of Nexium (Esomeprazole) supplied by GNH India

Nexium

Active Ingredient:
Esomeprazole
Origin:
EU

Nexium (Esomeprazole)

Esomeprazole, the active ingredient in Nexium, is a proton pump inhibitor presented as an injection for intravenous use. It reduces gastric acid secretion and is used in the management of gastro‑oesophageal reflux disease, erosive esophagitis, peptic ulcer disease, Helicobacter pylori eradication regimens, and prevention of NSAID‑induced gastric ulcers.

GNH India supplies Nexium as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Grünenthal Italia S.R.L.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Nexium, a proton pump inhibitor, acts on the gastric acid secretion pathway to treat several acid‑related conditions.

  • Gastro‑oesophageal reflux disease (GERD): provides symptomatic relief and promotes healing of esophageal irritation.
  • Erosive esophagitis: accelerates mucosal healing and reduces further damage.
  • Peptic ulcer disease: supports ulcer closure and prevents recurrence.
  • Helicobacter pylori eradication: enhances the effectiveness of antibiotic regimens.
  • Prevention of NSAID‑induced gastric ulcers: reduces risk of ulcer formation in patients requiring NSAID therapy.

How It Works

  • Esomeprazole selectively and irreversibly inhibits the H+/K+ ATPase enzyme (the gastric proton pump) located on the secretory surface of parietal cells. By blocking this final step of acid production, it markedly lowers both basal and stimulated gastric acid secretion, creating a less acidic gastric environment that facilitates healing of acid‑related lesions.

Side Effects

Common Side Effects

  • Headache: mild to moderate pain often resolving without intervention.
  • Diarrhea: loose stools that may be transient.
  • Nausea: feeling of queasiness, usually mild.
  • Abdominal pain: discomfort in the stomach region.
  • Flatulence: increased intestinal gas.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Clostridioides difficile infection: severe colitis requiring medical attention.
  • Severe allergic reactions (anaphylaxis): rash, swelling, difficulty breathing.
  • Stevens‑Johnson syndrome/toxic epidermal necrolysis: serious skin reactions.
  • Elevated liver enzymes: potential hepatic injury.
  • Hypomagnesemia: low magnesium levels with prolonged use.
  • Interstitial nephritis: kidney inflammation.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Assess renal and hepatic function: dose adjustment may be required in impairment.
  • Monitor serum magnesium: prolonged therapy can lead to depletion.
  • Evaluate for hypersensitivity: discontinue if allergic reactions occur.
  • Use cautiously in patients with cardiovascular disease: monitor for potential interactions.
  • Review concomitant medications: PPIs can affect absorption of certain drugs.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Esomeprazole may interact with several medicines, requiring attention to the level of risk.

Major Interactions (Avoid)

  • Atazanavir: reduced antiviral exposure, may compromise HIV therapy.
  • Rilpivirine: decreased plasma concentrations, reducing efficacy.
  • Clopidogrel: diminished activation, potentially lowering antiplatelet effect.

Moderate Interactions (Monitor Closely)

  • Digoxin: increased serum levels, monitor for toxicity.
  • Methotrexate: reduced clearance, watch for toxicity signs.
  • Warfarin: possible alteration of INR, monitor coagulation parameters.

Frequently Asked Questions

Nexium injection, containing esomeprazole, is indicated for the treatment of gastro‑oesophageal reflux disease, erosive esophagitis, peptic ulcer disease, as part of Helicobacter pylori eradication regimens, and for preventing gastric ulcers in patients receiving non‑steroidal anti‑inflammatory drugs.

Esomeprazole selectively and irreversibly blocks the H+/K+ ATPase enzyme, also known as the gastric proton pump, on the surface of parietal cells. This inhibition stops the final step of acid production, leading to a significant reduction in both basal and stimulated gastric acid secretion.

The specific dose and infusion rate of Nexium injection are determined by the prescribing clinician based on the patient’s condition, severity, and clinical response. Healthcare professionals should follow local prescribing guidelines and adjust dosing as needed.

The safety of esomeprazole injection in pregnancy or while breastfeeding has not been definitively established. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling if needed) and any required import documentation.

Esomeprazole is the S‑enantiomer of omeprazole and often provides more consistent acid suppression with a slightly longer duration of action. Compared with other PPIs, it may achieve faster healing of acid‑related lesions, though clinical outcomes are generally similar when appropriate dosing is used.

Nexium injection should be stored at 2‑8 °C (refrigerated). Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the product to maintain stability and potency.

The medication is given intravenously by a healthcare professional. It is typically diluted in a compatible IV solution and infused over a prescribed period, following aseptic technique and standard infusion protocols.

Serious risks include Clostridioides difficile‑associated diarrhea, severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome or toxic epidermal necrolysis, significant liver enzyme elevations, hypomagnesemia with prolonged use, and interstitial nephritis. Patients should be monitored for any signs of these conditions.

Patients with known hypersensitivity to esomeprazole, other proton pump inhibitors, or any component of the formulation should avoid the product. Caution is also advised for individuals with severe liver disease, certain cardiac conditions, or those taking medications that have major interactions with PPIs.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Esomeprazole

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT