Product image of Nexium (Esomeprazole Magnesium Trihydrate) supplied by GNH India

Nexium

Active Ingredient:
Esomeprazole Magnesium Trihydrate
Origin:
EU

Nexium (Esomeprazole Magnesium Trihydrate)

Esomeprazole, the active ingredient in Nexium, is a proton pump inhibitor presented as a tablet for oral use. It reduces gastric acid production and is prescribed for conditions such as gastro‑oesophageal reflux disease, erosive esophagitis, and ulcer‑related disorders.

GNH India supplies Nexium as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for global healthcare providers, ensuring consistent product availability across diverse markets.

Manufacturer / TM Owner

Grünenthal Gmbh

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Nexium (esomeprazole) acts on the gastric proton pump pathway to lower stomach acidity in several gastrointestinal disorders.

  • Gastro‑oesophageal reflux disease (GERD): alleviates heartburn and regurgitation by maintaining higher gastric pH.
  • Erosive esophagitis: promotes healing of inflamed esophageal tissue and prevents further damage.
  • NSAID‑induced gastric ulcer: protects the gastric lining and facilitates ulcer resolution.
  • Helicobacter pylori eradication (as part of combination therapy): enhances the effectiveness of antibiotics by reducing acid‑mediated bacterial survival.
  • Zollinger‑Ellison syndrome: controls excessive gastric acid secretion associated with gastrin‑producing tumors.

How It Works

  • Esomeprazole magnesium trihydrate irreversibly binds to the H+/K+‑ATPase enzyme (the gastric proton pump) located on the secretory surface of parietal cells. By blocking this final step of acid production, it markedly reduces the secretion of hydrogen ions into the gastric lumen, leading to sustained elevation of gastric pH and decreased acidity.

Side Effects

Esomeprazole may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Headache: mild pain often resolving without treatment.
  • Diarrhoea: loose stools that may be transient.
  • Nausea: feeling of sickness or urge to vomit.
  • Abdominal pain: discomfort in the stomach region.

Serious or Rare Side Effects

  • Clostridioides difficile infection: severe colitis requiring medical attention.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Low magnesium levels: can lead to muscle cramps or cardiac arrhythmia.
  • Bone fracture risk: long‑term use may affect calcium absorption.

Precautions & Warnings

Before prescribing Nexium, clinicians should consider several precautionary measures to ensure patient safety.

  • Assess renal function: dose adjustment may be needed in impaired kidneys.
  • Monitor magnesium levels: prolonged therapy can cause hypomagnesemia.
  • Evaluate liver disease: use with caution in hepatic impairment.
  • Use cautiously in the elderly: increased risk of fractures and infections.
  • Limit duration of therapy: re‑evaluate necessity after several weeks.
  • Store at room temperature: keep in the original container, protect from moisture.

Avoid Interactions

Esomeprazole can affect the plasma concentrations of several concomitant medications, requiring attention to interaction potential.

Major Interactions (Avoid)

  • Ketoconazole: reduced absorption leading to therapeutic failure.
  • Atazanavir: decreased antiviral efficacy due to increased gastric pH.
  • Clopidogrel: diminished antiplatelet effect increasing cardiovascular risk.

Moderate Interactions (Monitor Closely)

  • Digoxin: increased serum levels may cause toxicity.
  • Methotrexate: reduced clearance can raise toxicity risk.
  • Calcium carbonate: may decrease esomeprazole absorption if taken simultaneously.
  • Warfarin: possible alteration in anticoagulant effect; monitor INR.

Frequently Asked Questions

Nexium (esomeprazole) is prescribed for gastro‑oesophageal reflux disease (GERD), erosive esophagitis, NSAID‑induced gastric ulcers, as part of Helicobacter pylori eradication regimens, and for controlling acid hypersecretion in Zollinger‑Ellison syndrome.

Esomeprazole irreversibly inhibits the gastric H+/K+‑ATPase (proton pump) in parietal cells, which is the final step in acid secretion. Blocking this enzyme lowers hydrogen ion output, raising gastric pH and decreasing overall acidity.

The prescribed dose of Nexium is determined by the treating physician based on the specific indication, severity of disease, patient age, renal and hepatic function, and any concomitant therapies. Dosage may vary between short‑term and maintenance regimens.

Safety data for esomeprazole in pregnancy and lactation are limited. Prescribers should weigh potential benefits against possible risks and consider alternative treatments when possible. Women who are pregnant, planning pregnancy, or breastfeeding should discuss use with their healthcare provider.

To request Nexium, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Esomeprazole is the S‑isomer of omeprazole and often shows slightly higher bioavailability and more consistent acid suppression. Compared with other PPIs such as lansoprazole or pantoprazole, clinical efficacy is similar, but individual patient response and drug‑interaction profiles may differ, influencing selection.

Store Nexium at room temperature, below 25 °C, in the original packaging. Protect the tablets from moisture and direct sunlight to maintain stability throughout the shelf life.

Nexium is taken orally, usually as a whole tablet swallowed with water. It is generally recommended to take the dose before a meal, often in the morning, unless the prescriber advises a different schedule.

Serious risks include Clostridioides difficile infection, severe allergic reactions such as anaphylaxis, significant hypomagnesemia, and an increased risk of bone fractures with long‑term use. Patients should be monitored for these events, especially during extended therapy.

Nexium should be avoided in patients with known hypersensitivity to esomeprazole or any component of the formulation. Caution is advised for individuals with severe liver disease, those on interacting medications listed as major interactions, and patients who have had previous allergic reactions to proton pump inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Esomeprazole Magnesium Trihydrate

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT