Product image of Nexium (Esomeprazole Magnesium Trihydrate) supplied by GNH India

Nexium

Active Ingredient:
Esomeprazole Magnesium Trihydrate
Origin:
EU

Nexium (Esomeprazole Magnesium Trihydrate)

Esomeprazole magnesium trihydrate, the active ingredient in Nexium, is a proton pump inhibitor presented as an oral dosage form for oral use. It reduces gastric acid secretion and is used to treat acid‑related conditions such as gastro‑oesophageal reflux disease and related disorders.

GNH India supplies Nexium as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Grünenthal Gmbh

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Nexium is a proton pump inhibitor indicated for several acid‑related gastrointestinal conditions.

  • Gastro‑oesophageal reflux disease (GERD): reduces acid exposure and promotes healing of esophageal irritation.
  • Erosive oesophagitis: facilitates mucosal healing and symptom relief.
  • Zollinger‑Ellison syndrome: controls excessive gastric acid production.
  • NSAID‑induced gastric ulcer prevention: lowers risk of ulcer formation in patients taking NSAIDs.
  • Helicobacter pylori eradication (in combination therapy): enhances eradication rates when used with antibiotics.

How It Works

  • Esomeprazole magnesium trihydrate irreversibly binds to the H+/K+‑ATPase enzyme (gastric proton pump) on the secretory surface of parietal cells, blocking the final step of acid secretion. This inhibition leads to sustained suppression of gastric acid production, allowing healing of acid‑damaged mucosa and relief of related symptoms.

Side Effects

Common Side Effects

  • Headache: mild to moderate pain often reported.
  • Diarrhea: loose stools occurring during treatment.
  • Nausea: feeling of stomach upset.
  • Abdominal pain: discomfort or cramps.
  • Flatulence: increased gas.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis): swelling, rash, difficulty breathing.
  • Clostridioides difficile infection: severe colitis with watery diarrhea.
  • Low magnesium levels (hypomagnesemia): muscle cramps, irregular heartbeat.
  • Bone fractures: increased risk with long‑term use.
  • Stevens‑Johnson syndrome: serious skin reactions.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Assess renal function: adjust use in severe renal impairment.
  • Monitor magnesium levels: prolonged therapy may cause hypomagnesemia.
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
  • Use caution in patients with liver disease: consider dose adjustments.
  • Pregnancy and lactation: safety not established, weigh benefits against risks.
  • Store at room temperature: keep in the original container, protect from moisture.

Avoid Interactions

Esomeprazole may interact with several medications; review patient medication lists.

Major Interactions (Avoid)

  • Ketoconazole: reduced absorption and efficacy of ketoconazole.
  • Atazanavir: decreased plasma concentrations of atazanavir.
  • Clopidogrel: reduced activation of clopidogrel, diminishing antiplatelet effect.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible increase in INR, monitor coagulation.
  • Digoxin: may increase serum digoxin levels, watch for toxicity.
  • Methotrexate: potential increase in methotrexate exposure, monitor renal function.

Frequently Asked Questions

Nexium, containing esomeprazole magnesium trihydrate, is prescribed for acid‑related gastrointestinal disorders such as gastro‑oesophageal reflux disease (GERD), erosive oesophagitis, Zollinger‑Ellison syndrome, prevention of NSAID‑induced gastric ulcers, and as part of combination therapy for Helicobacter pylori eradication.

Esomeprazole magnesium trihydrate irreversibly inhibits the gastric H+/K+‑ATPase (proton pump) in parietal cells, blocking the final step of acid secretion. This results in sustained reduction of gastric acidity, allowing healing of the mucosa and relief of symptoms associated with excess acid.

The specific dose and dosing schedule of Nexium are determined by the prescribing healthcare professional based on the patient’s condition, severity, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

The safety of Nexium in pregnancy and lactation has not been definitively established. Healthcare providers will weigh the potential benefits against any possible risks before prescribing it to pregnant or nursing women.

To place an order, submit an enquiry on the Nexium product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nexium (esomeprazole) is a stereoisomer of omeprazole and often provides more consistent acid suppression with a similar safety profile. Compared with other PPIs, it may have a slightly faster onset of action and is frequently chosen for its proven efficacy in healing erosive oesophagitis.

Nexium should be stored at room temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Nexium is taken orally, usually as a whole tablet swallowed with water. It is commonly recommended to take the dose before a meal, but patients should follow the specific instructions provided by their prescriber.

Serious risks, though rare, include severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, low magnesium levels leading to muscle cramps or cardiac arrhythmias, increased risk of bone fractures with long‑term use, and severe skin reactions like Stevens‑Johnson syndrome.

Patients with known hypersensitivity to esomeprazole, other proton pump inhibitors, or any component of the formulation should avoid Nexium. Caution is also advised for individuals with severe liver disease, certain drug interactions, or those who are pregnant or breastfeeding without clear medical justification.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Esomeprazole Magnesium Trihydrate

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT