Product image of Nexium (Esomeprazole Magnesium Trihydrate) supplied by GNH India

Nexium

Active Ingredient:
Esomeprazole Magnesium Trihydrate
Origin:
EU

Nexium (Esomeprazole Magnesium Trihydrate)

Esomeprazole magnesium trihydrate, the active ingredient in Nexium, is a proton pump inhibitor presented as an oral dosage form for oral use. It reduces gastric acid production and is prescribed for conditions such as gastro‑oesophageal reflux disease, erosive oesophagitis, and Zollinger‑Ellison syndrome.

GNH India supplies Nexium as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for bulk and retail needs across global markets. Our distribution network ensures timely delivery and regulatory compliance.

Manufacturer / TM Owner

Grünenthal Gmbh

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Nexium, a proton pump inhibitor, is used to manage acid‑related disorders of the gastrointestinal tract.

  • Gastro‑oesophageal reflux disease (GERD): provides symptomatic relief and promotes healing of esophageal irritation.
  • Erosive oesophagitis: accelerates mucosal healing and reduces further damage.
  • Zollinger‑Ellison syndrome: controls excessive gastric acid secretion.
  • NSAID‑induced gastric ulcer prevention: reduces risk of ulcer formation in patients on non‑steroidal anti‑inflammatory drugs.
  • Helicobacter pylori eradication (as part of combination therapy): enhances eradication rates when used with antibiotics.

How It Works

  • Esomeprazole magnesium trihydrate irreversibly binds to the H+/K+ ATPase enzyme (gastric proton pump) located on the secretory surface of gastric parietal cells. By inhibiting this final step of acid production, it markedly reduces basal and stimulated gastric acid secretion, thereby increasing gastric pH and allowing healing of acid‑related lesions.

Side Effects

Esomeprazole may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Diarrhea: loose stools that may be transient.
  • Nausea: occasional feeling of queasiness.
  • Abdominal pain: mild discomfort in the stomach area.
  • Flatulence: increased intestinal gas.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Clostridioides difficile infection: severe colitis with diarrhea.
  • Low magnesium levels: may cause muscle cramps or arrhythmias.
  • Vitamin B12 deficiency: long‑term use can impair absorption.
  • Stevens‑Johnson syndrome: rare but serious skin reaction.

Precautions & Warnings

When prescribing or dispensing Nexium, consider the following safety measures.

  • Assess renal function: adjust use in severe renal impairment.
  • Monitor magnesium levels: prolonged therapy may cause hypomagnesemia.
  • Avoid abrupt discontinuation: risk of rebound acid hypersecretion.
  • Use with caution in pregnancy: limited data, weigh benefits versus risks.
  • Review concomitant medications: potential for drug interactions.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Esomeprazole can affect the pharmacokinetics of several co‑administered drugs.

Major Interactions (Avoid)

  • Clopidogrel: reduced antiplatelet effect.
  • Atazanavir: decreased exposure leading to sub‑therapeutic levels.
  • Methotrexate: increased toxicity due to reduced clearance.

Moderate Interactions (Monitor Closely)

  • Digoxin: may increase serum concentrations.
  • Theophylline: may increase serum concentrations, requiring dose adjustment.

Frequently Asked Questions

Nexium is prescribed for acid‑related gastrointestinal conditions such as gastro‑oesophageal reflux disease (GERD), erosive oesophagitis, Zollinger‑Ellison syndrome, prevention of NSAID‑induced gastric ulcers, and as part of combination therapy for Helicobacter pylori eradication.

Esomeprazole magnesium trihydrate irreversibly inhibits the gastric H+/K+ ATPase (proton pump) in parietal cells, blocking the final step of acid secretion. This suppression raises gastric pH, reducing irritation and allowing healing of acid‑damaged tissues.

The appropriate dose of Nexium is determined by the prescribing healthcare professional based on the specific indication, patient characteristics, and clinical response. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Nexium in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any potential risk to the fetus or infant. Healthcare providers will evaluate individual circumstances before prescribing.

To place an order, submit an enquiry on the Nexium product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and import documentation.

Nexium, as a proton pump inhibitor, provides more potent and longer‑lasting acid suppression than H2‑receptor antagonists. Compared with other PPIs, esomeprazole offers a consistent pharmacokinetic profile and may achieve faster symptom relief in some patients.

Store Nexium at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability.

Nexium is taken orally, usually as a whole tablet or capsule, with or without water. It is generally recommended to swallow the dosage form whole and follow the timing instructions provided by the prescriber, such as taking it before a meal.

Serious risks include severe allergic reactions, Clostridioides difficile infection, low magnesium levels, vitamin B12 deficiency with long‑term use, and rare skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience signs of these conditions.

Nexium should be avoided in patients with known hypersensitivity to esomeprazole, other proton pump inhibitors, or any component of the formulation. Caution is also advised for individuals with severe liver disease, and it is not recommended for use in children unless specifically prescribed.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Esomeprazole Magnesium Trihydrate

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT