Product image of Nexplanon (Etonogestrel) supplied by GNH India

Nexplanon

Active Ingredient:
Etonogestrel
Origin:
EU

Nexplanon (Etonogestrel)

Etonogestrel, the active ingredient in Nexplanon, is a progestin presented as a 68 mg subdermal implant for subcutaneous use. It provides long‑acting reversible contraception by preventing ovulation and altering cervical mucus, offering up to three years of pregnancy protection for women of reproductive age.

GNH India supplies Nexplanon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Organon France

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Indications & Clinical Uses

Etonogestrel is a progestin used in hormonal contraception to prevent pregnancy.

  • Prevention of pregnancy (contraception): provides highly effective, reversible contraception for up to three years.
  • Family planning: enables women to plan and space pregnancies with a single, low‑maintenance device.
  • Long‑acting reversible contraception: offers a convenient alternative to daily oral pills or monthly injectables.

How It Works

  • Etonogestrel is released slowly from the subdermal implant, maintaining steady plasma concentrations that suppress the luteinizing hormone surge, thereby inhibiting ovulation. It also thickens cervical mucus, reducing sperm penetration, and induces endometrial changes that are unfavorable for implantation, resulting in effective contraception.

Side Effects

Nexplanon may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Irregular vaginal bleeding or spotting
  • Amenorrhea (absence of periods)
  • Headache
  • Weight gain
  • Acne or skin changes
  • Breast tenderness

Serious or Rare Side Effects

  • Deep vein thrombosis or pulmonary embolism
  • Severe allergic reaction (anaphylaxis, rash, swelling)
  • Infection at the insertion site
  • Implant migration or extrusion
  • Hormonal imbalance causing mood changes
  • Significant hypertension

Precautions & Warnings

Before initiating Nexplanon therapy, several safety considerations should be reviewed.

  • Pregnancy testing: confirm the patient is not pregnant prior to insertion.
  • Smoking: advise women over 35 who smoke to consider alternative methods.
  • Thromboembolic history: assess for prior clotting disorders or risk factors.
  • Medication review: evaluate concomitant drugs that may reduce efficacy.
  • Follow‑up schedule: plan removal or replacement at the three‑year mark.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Etonogestrel can interact with other medicines that affect its metabolism or hormonal activity.

Major Interactions (Avoid)

  • Rifampin, carbamazepine, phenytoin: strong enzyme inducers that markedly lower implant effectiveness.
  • St. John's wort: herbal inducer that may reduce plasma levels.
  • Certain antiretrovirals (e.g., efavirenz): can compromise contraceptive reliability.

Moderate Interactions (Monitor Closely)

  • Griseofulvin: moderate enzyme inducer, may require additional contraceptive measures.
  • Antifungal azoles (ketoconazole, itraconazole): may increase hormone levels, monitor for side effects.
  • Antiepileptic drugs with moderate inducing potential (e.g., phenobarbital): assess efficacy periodically.

Frequently Asked Questions

Nexplanon is a subdermal implant that delivers the progestin etonogestrel to provide long‑acting reversible contraception. It is indicated for the prevention of pregnancy in women of reproductive age and offers up to three years of continuous protection.

Etonogestrel released from the implant suppresses the luteinizing hormone surge, which blocks ovulation. It also thickens cervical mucus, making it difficult for sperm to travel, and alters the endometrium, creating an environment unsuitable for implantation.

Nexplanon is supplied as a single 68 mg subdermal implant. The exact dosing schedule, including insertion and removal timing, is determined by the prescribing healthcare professional based on clinical guidelines.

Nexplanon is classified as pregnancy category X, meaning it must not be used by women who are pregnant. Women should use an alternative method if they become pregnant. Limited data exist for breastfeeding, and a healthcare provider should assess risks versus benefits.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Compared with daily oral pills, Nexplanon offers higher typical‑use effectiveness and eliminates the need for daily adherence. Unlike injectable progestins, it requires only a single insertion for up to three years, providing greater convenience and consistent hormone levels.

Nexplanon should be stored at ambient temperature, below 25 °C, in its original sealed packaging. Protect the device from moisture, direct sunlight and extreme temperatures to maintain its stability until the time of insertion.

A qualified healthcare professional inserts the Nexplanon implant subdermally in the inner side of the upper arm using a sterile applicator. The procedure is minimally invasive, performed in an outpatient setting, and the implant remains in place for up to three years before removal or replacement.

Serious risks include rare but potentially life‑threatening events such as deep vein thrombosis, pulmonary embolism, severe allergic reactions, and infection at the insertion site. Users should seek immediate medical attention if they experience unexplained swelling, severe pain, shortness of breath, or signs of an allergic response.

Nexplanon is contraindicated in women who are pregnant, have a known hypersensitivity to etonogestrel or any component of the device, have active breast cancer, or have a history of thromboembolic disorders without appropriate medical evaluation. A thorough medical assessment is required before insertion.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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