Product image of Nexplanon (Etonogestrel) supplied by GNH India

Nexplanon

Active Ingredient:
Etonogestrel
Origin:
EU

Nexplanon (Etonogestrel)

Etonogestrel, the active ingredient in Nexplanon, is a progestin presented as a 68 mg subdermal implant for subcutaneous use. It provides long‑acting hormonal contraception to prevent pregnancy in women of reproductive age.

GNH India supplies Nexplanon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Organon Italia S.R.L.

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Indications & Clinical Uses

Nexplanon, containing etonogestrel, is used within the hormonal contraceptive pathway to prevent unintended pregnancy.

  • Prevention of pregnancy: delivers continuous contraception for up to three years after insertion.

How It Works

  • Etonogestrel released from the subdermal implant binds to progesterone receptors in the hypothalamus and pituitary, suppressing the luteinizing hormone surge and thereby inhibiting ovulation. It also thickens cervical mucus to impede sperm penetration and induces endometrial changes that reduce the likelihood of implantation.

Side Effects

Nexplanon may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Irregular vaginal bleeding or spotting
  • Amenorrhea (absence of periods)
  • Headache
  • Weight gain
  • Acne or skin changes
  • Breast tenderness

Serious or Rare Side Effects

  • Deep vein thrombosis or pulmonary embolism
  • Severe allergic reaction (anaphylaxis)
  • Infection at the insertion site
  • Ectopic pregnancy if contraceptive failure occurs
  • Hormone‑sensitive tumor growth

Precautions & Warnings

Before Nexplanon insertion, clinicians should evaluate patient history and counsel on potential risks.

  • Contraindications: Do not use in women with known thromboembolic disorders or active breast cancer.
  • Screening: Assess for liver disease or hormone‑sensitive conditions.
  • Bleeding patterns: Counsel that irregular bleeding is common during the first months.
  • Pregnancy: Discontinue immediately if pregnancy is confirmed.
  • Storage: Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Nexplanon can interact with other medicines that affect hormone metabolism or clotting risk.

Major Interactions (Avoid)

  • Rifampin, carbamazepine, phenytoin: enzyme inducers that may reduce contraceptive efficacy.
  • St. John's wort: herbal inducer that can lower etonogestrel levels.
  • Efavirenz: antiretroviral that may decrease hormone concentrations.

Moderate Interactions (Monitor Closely)

  • Ketoconazole, itraconazole: antifungals that may increase hormone levels.
  • Combined hormonal contraceptives: concurrent use may raise clotting risk.
  • Anticoagulants: monitor for altered bleeding tendencies.

Frequently Asked Questions

Nexplanon is a subdermal implant that provides long‑acting hormonal contraception. It is prescribed to prevent unintended pregnancy in women of reproductive age and offers protection for up to three years after a single insertion.

Etonogestrel released from the implant binds to progesterone receptors, suppressing the luteinizing hormone surge and preventing ovulation. It also thickens cervical mucus and alters the endometrium, creating multiple barriers to fertilization and implantation.

The Nexplanon implant contains a fixed 68 mg dose of etonogestrel. The prescriber determines suitability and inserts the single‑use device; no additional dosing regimen is required by the patient.

Nexplanon is contraindicated in pregnancy (pregnancy category X) and should be removed if pregnancy occurs. It is generally considered safe for breastfeeding women, but clinicians should discuss individual risks and benefits with the patient.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Compared with oral contraceptives, Nexplanon offers a once‑in‑a‑lifetime insertion lasting up to three years, eliminating daily adherence. Unlike intrauterine devices, it does not require uterine placement and can be removed at any time without affecting future fertility.

Nexplanon should be stored at room temperature, below 25 °C, in its original sealed packaging. Protect the implant from moisture and direct sunlight until it is inserted by a qualified healthcare professional.

A qualified clinician inserts the 68 mg etonogestrel implant subdermally into the inner side of the upper arm using a sterile applicator. The procedure takes only a few minutes and is performed in an outpatient setting.

Serious risks include deep vein thrombosis, pulmonary embolism, severe allergic reactions, infection at the insertion site, and rare cases of ectopic pregnancy if contraceptive failure occurs. Patients should seek immediate medical attention if they experience symptoms such as leg swelling, chest pain, or severe skin reactions.

Women with a history of thromboembolic disorders, active breast cancer, severe liver disease, or known hypersensitivity to etonogestrel or any component of the implant should not use Nexplanon. It is also contraindicated during pregnancy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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