Product image of Nezefib (Dexamethasone Sodium Phosphate, Chloramphenicol) supplied by GNH India

Nezefib

Active Ingredient:
Dexamethasone Sodium Phosphate, Chloramphenicol
Origin:
EU

Nezefib (Dexamethasone Sodium Phosphate, Chloramphenicol)

Dexamethasone sodium phosphate, the active ingredient in Nezefib, is a corticosteroid presented as a combination ophthalmic preparation for ocular use. It is combined with chloramphenicol to treat bacterial eye infections and inflammatory ocular conditions.\n\nGNH India supplies Nezefib as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Rafarm Sa.

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Indications & Clinical Uses

  • Nezefib, a corticosteroid‑antibiotic ophthalmic preparation, is used to manage inflammatory and bacterial eye conditions.\n\n- Bacterial conjunctivitis: reduces bacterial load and alleviates symptoms.\n- Inflammatory ocular conditions (e.g., uveitis, iritis): suppresses inflammation and prevents tissue damage.\n- Post‑operative eye inflammation: controls swelling and prevents infection after eye surgery.

How It Works

  • Dexamethasone sodium phosphate binds to intracellular glucocorticoid receptors, altering gene transcription to inhibit pro‑inflammatory cytokines and reduce vascular permeability. Chloramphenicol binds to the 50S ribosomal subunit of susceptible bacteria, blocking protein synthesis and halting bacterial growth. The combined actions provide anti‑inflammatory and antibacterial effects within the eye.

Side Effects

  • Nezefib may cause ocular and systemic adverse reactions, most of which are mild and reversible.\n\nCommon Side Effects:\n- Transient burning or stinging on instillation\n- Mild eye irritation or redness\n- Temporary blurred vision\n- Increased intra‑ocular pressure in susceptible patients\n\nSerious or Rare Side Effects:\n- Secondary ocular infection or fungal overgrowth\n- Allergic contact dermatitis of the eyelid\n- Severe elevation of intra‑ocular pressure leading to glaucoma\n- Systemic hypersensitivity reactions (rare)

Precautions & Warnings

  • Nezefib should be used with caution in certain patient groups and situations.\n\n- Pregnancy: safety not established; use only if benefits outweigh risks.\n- Breastfeeding: unknown; consider potential risk to infant.\n- Existing ocular infection: assess bacterial susceptibility before use.\n- Patients with glaucoma or ocular hypertension: monitor intra‑ocular pressure closely.\n- Concurrent use of other corticosteroid eye drops: avoid additive steroid effect.\n- Store at room temperature (≤25°C): keep in original container, protect from light and moisture.

Avoid Interactions

  • Nezefib can interact with other ophthalmic agents and systemic drugs.\n\nMajor Interactions (Avoid):\n- Systemic corticosteroids: additive immunosuppression and increased infection risk.\n- Topical NSAIDs or other anti‑inflammatory eye drops: heightened risk of corneal melting.\n\nModerate Interactions (Monitor Closely):\n- Anticholinergic eye drops: may reduce tear production, increasing irritation.\n- Beta‑blocker eye drops: possible additive intra‑ocular pressure lowering effect.\n- Other ophthalmic antibiotics: risk of antagonistic bacterial resistance patterns.

Frequently Asked Questions

Nezefib is an ophthalmic preparation that combines a corticosteroid with an antibiotic. It is prescribed to treat bacterial conjunctivitis, reduce inflammation in conditions such as uveitis or iritis, and to manage post‑operative eye swelling and prevent infection after eye surgery.

Dexamethasone sodium phosphate penetrates ocular tissues and binds to intracellular glucocorticoid receptors. This binding modifies gene transcription, leading to decreased production of inflammatory mediators, reduced vascular permeability, and suppression of immune cell activity, thereby providing anti‑inflammatory effects.

The dosing regimen for Nezefib is determined by the prescribing clinician based on the specific indication, severity of the condition, and patient factors. The prescriber will specify the number of drops, frequency, and duration of therapy.

Safety data for Nezefib in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by the treating physician.

To order Nezefib, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nezefib offers a dual mechanism by combining a potent corticosteroid with a broad‑spectrum antibiotic, which can simplify therapy compared with using separate anti‑inflammatory and antibacterial drops. Alternative regimens may require multiple products, whereas Nezefib provides combined coverage in a single formulation.

Nezefib should be stored at room temperature, not exceeding 25°C. Keep the container tightly closed, protect it from direct light and moisture, and avoid freezing. Do not use the product if the solution appears discolored or contains particles.

Nezefib is applied as an eye drop. The prescriber will instruct the patient on the number of drops per eye, the frequency (e.g., one to two drops several times daily), and the length of treatment. Hands should be washed before instillation, and the dropper tip should not touch the eye or surrounding tissues.

Serious risks include secondary ocular infections such as fungal overgrowth, severe elevation of intra‑ocular pressure that can lead to glaucoma, and rare systemic hypersensitivity reactions. Patients should be monitored for signs of infection, vision changes, or increased eye pressure, and any concerning symptoms should be reported promptly.

Nezefib is contraindicated in patients with known hypersensitivity to dexamethasone, chloramphenicol, or any component of the formulation. It should also be avoided in individuals with active viral eye infections such as herpes simplex keratitis, as corticosteroids can exacerbate viral replication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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