Product image of Nezefib (Dexamethasone Sodium Phosphate, Chloramphenicol) supplied by GNH India

Nezefib

Active Ingredient:
Dexamethasone Sodium Phosphate, Chloramphenicol
Origin:
EU

Nezefib (Dexamethasone Sodium Phosphate, Chloramphenicol)

Dexamethasone sodium phosphate, the active ingredient in Nezefib, is a corticosteroid presented as a sterile ophthalmic solution for ocular use. Combined with chloramphenicol, it treats inflammatory eye conditions and bacterial infections, providing both anti‑inflammatory and broad‑spectrum antibacterial effects for patients requiring postoperative or therapeutic eye care.

GNH India supplies Nezefib as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. Customers benefit from regulatory compliance, batch traceability, and responsive technical support.

Manufacturer / TM Owner

Rafarm Sa.

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Indications & Clinical Uses

Nezefib is indicated for ocular conditions where inflammation and bacterial infection coexist, addressing both pathways.

  • Ocular inflammation: reduces swelling, pain and cellular infiltrate in conditions such as uveitis or postoperative inflammation.
  • Bacterial conjunctivitis: eliminates susceptible bacteria, relieving redness, discharge and discomfort.
  • Pre‑ and post‑operative eye surgery prophylaxis: prevents infection and controls inflammation before and after ophthalmic procedures.

How It Works

  • Dexamethasone sodium phosphate binds to intracellular glucocorticoid receptors, modulating gene transcription to suppress pro‑inflammatory cytokines, reduce vascular permeability and inhibit leukocyte migration in ocular tissues. Chloramphenicol penetrates bacterial cells and binds to the 50S ribosomal subunit, blocking peptide‑bond formation and halting protein synthesis, resulting in a broad‑spectrum bacteriostatic effect. The combined actions provide simultaneous anti‑inflammatory and antibacterial activity within the eye.

Side Effects

Nezefib may cause ocular and systemic adverse reactions; they are categorized by frequency and severity.

Common Side Effects

  • Eye irritation or burning sensation.
  • Transient blurred vision.
  • Mild increase in intra‑ocular pressure.
  • Local allergic conjunctivitis.

Serious or Rare Side Effects

  • Secondary ocular infection or worsening of existing infection.
  • Development of cataract with prolonged use.
  • Glaucoma due to sustained intra‑ocular pressure rise.
  • Severe allergic reaction including anaphylaxis.

Precautions & Warnings

When prescribing Nezefib, clinicians should consider several safety measures.

  • Pregnancy: safety not established; use only if benefits outweigh risks.
  • Breastfeeding: unknown excretion; consider risk‑benefit before prescribing.
  • Pre‑existing glaucoma: monitor intra‑ocular pressure closely.
  • Concurrent ocular infection: assess need for additional antimicrobial coverage.
  • Use in children: limit duration and follow specialist guidance.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Nezefib can interact with other medicines; awareness of interaction severity guides clinical decisions.

Major Interactions (Avoid)

  • Systemic corticosteroids: may increase systemic steroid exposure.
  • Systemic chloramphenicol: risk of additive bone‑marrow suppression.
  • Topical non‑steroidal anti‑inflammatory eye drops: heightened risk of corneal melting.
  • Anticholinergic ophthalmic agents: may reduce drug absorption.

Moderate Interactions (Monitor Closely)

  • Other topical steroids: cumulative steroid effect on intra‑ocular pressure.
  • Antiviral eye drops: possible reduced antiviral efficacy.
  • Glaucoma medications: monitor pressure when used together.

Frequently Asked Questions

Nezefib is a prescription ophthalmic preparation that combines a corticosteroid with an antibacterial agent. It is used to treat ocular inflammation such as uveitis or postoperative swelling, to manage bacterial conjunctivitis, and to provide prophylactic protection against infection and inflammation before and after eye surgery.

Dexamethasone sodium phosphate enters ocular cells and binds to glucocorticoid receptors. This binding alters gene expression, leading to reduced production of inflammatory mediators, decreased vascular permeability, and inhibition of leukocyte migration, thereby suppressing inflammation in the eye.

The dosing regimen for Nezefib is determined by the prescribing ophthalmologist or qualified healthcare professional based on the specific condition, severity, and patient factors. The prescriber will provide detailed instructions on the number of drops, frequency, and duration of therapy.

Safety data for Nezefib in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any potential risk to the fetus or infant. Healthcare providers should discuss the risk‑benefit profile with the patient before initiating therapy.

To request Nezefib, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Nezefib uniquely combines a potent corticosteroid (dexamethasone) with a broad‑spectrum antibacterial (chloramphenicol) in a single formulation. This dual action can simplify treatment regimens compared with using separate steroid and antibiotic drops, but clinicians must consider the safety profile of each component when selecting therapy.

Nezefib should be stored at room temperature, protected from light and moisture, and kept in its original container. Do not freeze the product. Check the label for any specific storage instructions and discard any solution that appears discolored or contaminated.

Nezefib is applied as an eye drop. The prescribed number of drops is placed into the conjunctival sac of the affected eye(s) according to the healthcare provider’s instructions, typically avoiding contact with the eyelid or lashes to maintain sterility.

Serious risks include secondary ocular infection, development of cataract or glaucoma with prolonged use, and severe allergic reactions such as anaphylaxis. Patients should be monitored for signs of increased intra‑ocular pressure, visual changes, or systemic allergic symptoms and seek medical attention promptly if they occur.

Nezefib is contraindicated in patients with known hypersensitivity to dexamethasone, chloramphenicol, or any excipients in the formulation. Caution is advised in individuals with active viral eye infections, uncontrolled glaucoma, or those who are pregnant or breastfeeding without a clear benefit‑risk assessment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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