Product image of Nezodia (Linagliptin) supplied by GNH India

Nezodia

Active Ingredient:
Linagliptin
Origin:
EU

Nezodia (Linagliptin)

Linagliptin, the active ingredient in Nezodia, is a DPP-4 inhibitor presented as an oral tablet for oral use. It is indicated for the management of blood glucose levels in adults with type 2 diabetes mellitus, typically as part of a comprehensive treatment plan that includes diet and exercise.

GNH India supplies Nezodia as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with reliable quality assurance and regulatory compliance, and on-time delivery to meet global demand across multiple continents.

Manufacturer / TM Owner

Innovis Pharma

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Indications & Clinical Uses

Nezodia (linagliptin) is a DPP-4 inhibitor used in the management of type 2 diabetes mellitus.

  • Type 2 diabetes mellitus: improves glycemic control when combined with diet and exercise.
  • Adjunct to metformin therapy: provides additional glucose lowering in patients inadequately controlled on metformin alone.
  • Monotherapy in metformin-intolerant patients: offers an alternative oral option for glycemic management.

How It Works

  • Linagliptin selectively inhibits the dipeptidyl peptidase-4 (DPP-4) enzyme, which degrades the incretin hormones GLP-1 and GIP. By blocking DPP-4, linagliptin increases endogenous GLP-1 and GIP levels, enhancing glucose-dependent insulin secretion and suppressing glucagon release after meals, thereby lowering post-prandial and overall blood glucose concentrations without causing hypoglycaemia when used alone.

Side Effects

Linagliptin may be associated with several adverse reactions, ranging from mild to serious.

Common Side Effects

  • Upper respiratory tract infection: mild cough or nasal congestion.
  • Headache: transient mild to moderate pain.
  • Nasopharyngitis: inflammation of the nasal passages and throat.
  • Gastrointestinal discomfort: nausea or abdominal pain.

Serious or Rare Side Effects

  • Pancreatitis: severe abdominal pain with vomiting.
  • Severe hypersensitivity reactions: rash, angioedema, or anaphylaxis.
  • Hepatic enzyme elevation: increased ALT or AST levels.

Precautions & Warnings

When prescribing Nezodia, clinicians should consider several safety and handling precautions.

  • Renal impairment: dose adjustment may be required; monitor renal function.
  • Hepatic disease: use with caution and monitor liver enzymes.
  • Cardiovascular risk: evaluate patient history of heart disease.
  • Concomitant sulfonylureas: increased risk of hypoglycaemia; adjust dose if needed.
  • Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture.

Avoid Interactions

Linagliptin can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampicin): may reduce linagliptin exposure.
  • Combination with insulin or sulfonylureas: can increase risk of hypoglycaemia.

Moderate Interactions (Monitor Closely)

  • Diuretics (e.g., thiazides): may enhance hypoglycaemic effect.
  • ACE inhibitors or ARBs: monitor blood pressure and renal function.
  • Anticoagulants (e.g., warfarin): observe INR for potential changes.

Frequently Asked Questions

Nezodia contains linagliptin, a DPP-4 inhibitor indicated for the treatment of type 2 diabetes mellitus in adults. It helps lower elevated blood glucose levels when used together with diet, exercise, and other antidiabetic agents as part of a comprehensive diabetes management plan.

Linagliptin works by selectively blocking the enzyme dipeptidyl peptidase‑4 (DPP‑4). This inhibition raises the levels of the incretin hormones GLP‑1 and GIP, which increase insulin secretion and reduce glucagon release in a glucose‑dependent manner, leading to improved blood sugar control.

The appropriate dose of Nezodia is determined by the prescribing healthcare professional based on the individual’s clinical condition, renal function, and concomitant therapies. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of linagliptin in pregnancy and lactation has not been fully established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To order Nezodia, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nezodia (linagliptin) is a once‑daily DPP‑4 inhibitor that does not require dose adjustment in mild to moderate renal impairment, unlike some other agents in the class. Its efficacy in lowering HbA1c is comparable, while its safety profile is similar, with low risk of hypoglycaemia when used alone.

Nezodia tablets should be stored at ambient temperature, preferably below 25 °C, in the original blister pack or container. Protect the product from moisture and direct sunlight to maintain stability throughout its shelf life.

Nezodia is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water and not chewed or crushed, unless otherwise directed by a healthcare professional.

Serious adverse events associated with Nezodia include acute pancreatitis, severe hypersensitivity reactions such as rash, angioedema or anaphylaxis, and significant elevations in liver enzymes. Patients should seek immediate medical attention if they experience persistent abdominal pain, signs of an allergic reaction, or jaundice.

Nezodia should be avoided in individuals with known hypersensitivity to linagliptin or any component of the formulation. Caution is advised for patients with severe renal impairment, hepatic disease, or a history of pancreatitis, and it should be used only under medical supervision in these populations.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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