Product image of Nibel (Nebivolol) supplied by GNH India

Nibel

Active Ingredient:
Nebivolol
Origin:
EU

Nibel (Nebivolol)

Nebivolol, the active ingredient in Nibel, is a beta blocker presented as an oral tablet for oral use. It selectively blocks β1‑adrenergic receptors while enhancing nitric‑oxide release, helping to lower blood pressure and improve cardiac function in patients with hypertension and heart failure.

GNH India supplies Nibel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality, regulatory compliance, and reliable supply chain management for healthcare providers.

Manufacturer / TM Owner

Belupo D.D.

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Indications & Clinical Uses

  • Nebivolol is used to manage conditions within the cardiovascular disease spectrum, primarily by lowering blood pressure and supporting heart function.
  • Hypertension: reduces systolic and diastolic blood pressure, decreasing cardiovascular risk.
  • Heart failure: improves left‑ventricular ejection fraction and lowers hospitalization rates.
  • Chronic heart failure with reduced ejection fraction: enhances cardiac output and symptom control.

How It Works

  • Nebivolol acts as a selective β1‑adrenergic receptor antagonist, decreasing heart rate and myocardial contractility, which lowers cardiac output and blood pressure. It also stimulates endothelial nitric‑oxide synthase, increasing nitric‑oxide release and causing vasodilation, thereby reducing peripheral vascular resistance. The combined β1‑blockade and nitric‑oxide‑mediated vasodilation provide its antihypertensive and heart‑failure benefits.

Side Effects

Nebivolol may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Headache
  • Dizziness
  • Fatigue
  • Nausea
  • Bradycardia
  • Peripheral edema

Serious or Rare Side Effects

  • Severe bradycardia
  • Marked hypotension
  • Bronchospasm, especially in asthma/COPD
  • AV block or heart block
  • Allergic reactions (rash, angioedema)
  • Hepatic dysfunction

Precautions & Warnings

  • When prescribing Nebivolol, clinicians should consider several safety measures to minimize risks.
  • Monitor blood pressure: check regularly during initiation and dose adjustments.
  • Assess cardiac function: especially in patients with heart failure or conduction disorders.
  • Caution in asthma or COPD: beta‑blockade may precipitate bronchospasm.
  • Avoid abrupt discontinuation: may lead to rebound hypertension or tachycardia.
  • Adjust dose in renal impairment: monitor renal function and modify as needed.
  • Store at room temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Nebivolol can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Combined with other β‑blockers: risk of excessive bradycardia.
  • Concomitant use with non‑dihydropyridine calcium channel blockers (verapamil, diltiazem): may cause severe AV block.
  • Potent CYP2D6 inhibitors (paroxetine, fluoxetine, quinidine): increase nebivolol plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Co‑administration with diuretics: may enhance hypotensive effect.
  • Use with ACE inhibitors or ARBs: additive blood‑pressure lowering.
  • Concurrent antihypertensives (e.g., hydralazine): may require dose adjustment.
  • NSAIDs: may reduce antihypertensive efficacy.

Frequently Asked Questions

Nibel contains nebivolol, which is prescribed to treat hypertension and to manage chronic heart failure. By lowering blood pressure and improving cardiac output, it helps reduce the risk of cardiovascular complications in these patient groups.

Nebivolol selectively blocks β1‑adrenergic receptors, decreasing heart rate and contractility, which reduces cardiac output. It also stimulates nitric‑oxide release from the endothelium, causing vasodilation and lowering peripheral resistance, together resulting in lower blood pressure.

The appropriate dose of Nibel is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and any concomitant medications. Dosage adjustments may be required for renal or hepatic impairment.

Safety of nebivolol in pregnancy and lactation has not been fully established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To request Nibel, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nebivolol is a highly selective β1‑blocker that also enhances nitric‑oxide‑mediated vasodilation, which can provide better tolerability regarding metabolic effects and fewer bronchospastic reactions compared with non‑selective beta‑blockers. Its dual action may result in additional blood‑pressure reduction beyond pure β‑blockade.

Store Nibel at room temperature, below 25 °C. Keep the tablets in the original container, protect them from moisture and direct light, and ensure the packaging remains tightly closed until use.

Nibel is taken orally, usually once daily, with or without food, as directed by the prescribing physician. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed.

Serious risks include severe bradycardia, marked hypotension, bronchospasm in patients with asthma or COPD, and heart block. Patients should be monitored for signs of these reactions, especially when initiating therapy or adjusting the dose.

Nibel should be avoided in patients with known hypersensitivity to nebivolol or any excipients, those with severe bradycardia, second‑ or third‑degree AV block without a pacemaker, and individuals with uncontrolled asthma or severe chronic obstructive pulmonary disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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