Product image of Nicardipine Aguettant (Nicardipine Hydrochloride) supplied by GNH India

Nicardipine Aguettant

Active Ingredient:
Nicardipine Hydrochloride
Origin:
EU

Nicardipine Aguettant (Nicardipine Hydrochloride)

Nicardipine Hydrochloride, the active ingredient in Nicardipine Aguettant, is a calcium channel blocker (dihydropyridine) presented as an intravenous solution for intravenous use. It treats hypertension, angina pectoris and acute coronary syndrome in adult patients, and the formulation is intended for controlled infusion in acute‑care settings.

GNH India supplies Nicardipine Aguettant as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

  • Nicardipine is a dihydropyridine calcium channel blocker used in cardiovascular conditions that involve arterial constriction.
  • Hypertension: lowers systemic blood pressure by causing arterial vasodilation.
  • Angina pectoris: relieves chest pain by improving myocardial oxygen delivery.
  • Acute coronary syndrome: stabilises coronary circulation and reduces ischemic risk.

How It Works

  • Nicardipine selectively blocks L‑type calcium channels on vascular smooth muscle, inhibiting calcium influx. This action produces arterial vasodilation, reduces peripheral vascular resistance, decreases afterload, and enhances coronary blood flow, thereby lowering blood pressure and relieving myocardial oxygen demand.

Side Effects

Adverse reactions may occur with nicardipine administration.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness of skin.
  • Tachycardia: increased heart rate during infusion.
  • Peripheral edema: swelling of lower extremities.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring intervention.
  • Myocardial infarction: rare occurrence during rapid infusion.
  • Arrhythmias: potentially life‑threatening rhythm disturbances.
  • Allergic reactions: rash, bronchospasm, or anaphylaxis.

Precautions & Warnings

  • Careful monitoring and patient assessment are essential when using nicardipine.
  • Monitor blood pressure: check regularly during infusion.
  • Assess cardiac function: avoid rapid infusion in severe aortic stenosis.
  • Use caution in hepatic impairment: dose adjustment may be required.
  • Avoid concomitant potent vasodilators: risk of additive hypotension.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Nicardipine may interact with several drug classes; awareness of interaction severity guides clinical decisions.

Major Interactions (Avoid)

  • Other calcium channel blockers (e.g., amlodipine): risk of excessive hypotension.
  • Nitrates: additive vasodilation may cause severe hypotension.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): increase nicardipine plasma levels.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask tachycardia.
  • Diuretics: can enhance hypotensive effect.
  • ACE inhibitors: monitor renal function and potassium balance.

Frequently Asked Questions

Nicardipine Aguettant is an intravenous calcium channel blocker indicated for the management of hypertension, angina pectoris, and acute coronary syndrome in adult patients who require rapid blood‑pressure control or coronary vasodilation.

Nicardipine Hydrochloride selectively blocks L‑type calcium channels on arterial smooth muscle, preventing calcium entry. This causes arterial vasodilation, reduces peripheral vascular resistance, lowers blood pressure, and improves coronary blood flow, thereby relieving cardiac workload.

The dosage of Nicardipine Aguettant is determined by the prescribing clinician based on the patient’s clinical status, blood‑pressure targets, and response to therapy. The prescriber sets the infusion rate and duration according to established guidelines.

Safety data for Nicardipine in pregnancy and lactation are limited, and the product is classified as pregnancy category unknown. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and under close medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Nicardipine is a dihydropyridine with a rapid onset and short duration, making it suitable for intravenous use in acute settings. Compared with oral agents like amlodipine, it allows precise titration and immediate blood‑pressure control, but requires careful monitoring for hypotension.

Nicardipine Aguettant should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the solution from light and moisture, and avoid freezing. Inspect the vial for particulate matter before use.

The product is supplied as an intravenous solution for infusion. It is administered by controlled IV infusion, typically using a calibrated pump, with the rate adjusted by the clinician based on blood‑pressure response and patient tolerance.

Serious risks include severe hypotension, myocardial infarction, life‑threatening arrhythmias, and allergic reactions such as anaphylaxis. Patients should be monitored continuously for hemodynamic changes and signs of cardiac ischemia during infusion.

Nicardipine is contraindicated in patients with known hypersensitivity to nicardipine or any component of the formulation, and it should be used with extreme caution in individuals with severe aortic stenosis, uncontrolled heart failure, or profound hypotension.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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