Nicardipine Hydrochloride (Injection) 20mg/200ml

Nicardipine Hydrochloride is used to manage cardiovascular conditions by acting on the vascular system.

• Hypertensive emergencies: Rapidly reduces blood pressure in critical situations.
• Acute severe hypertension: Controls dangerously high blood pressure levels.
• Angina pectoris: Improves blood flow to the heart, reducing chest pain.
• Peri-operative hypertension: Manages blood pressure during surgical procedures.

• Nicardipine Hydrochloride works by selectively inhibiting L-type calcium channels in vascular smooth muscle, preventing calcium influx. This leads to arterial vasodilation, reducing systemic vascular resistance and lowering blood pressure without significantly affecting cardiac output.

Nicardipine Hydrochloride may cause various side effects, ranging from common to serious.

Common Side Effects

• Headache: A frequent side effect due to vasodilation.
• Hypotension: Lowered blood pressure may occur.
• Tachycardia: Increased heart rate is possible.
• Nausea or vomiting: Gastrointestinal discomfort may arise.
• Peripheral edema: Swelling in the legs or ankles can occur.
• Dizziness: Lightheadedness may be experienced.

Serious or Rare Side Effects

• Severe hypotension: May lead to fainting or dizziness.
• Severe allergic reactions: Includes hives, swelling, or difficulty breathing.
• Severe IV-site problems: Intense pain, swelling, or skin changes at the injection site.
• Liver problems: Elevated liver enzymes or jaundice may occur.

Nicardipine Hydrochloride should be used with caution in certain conditions and with proper storage.

• Advanced aortic stenosis: Contraindicated due to potential worsening of symptoms.
• Heart failure: Use with caution as it may affect cardiac function.
• Recent stroke: Sudden blood pressure drops could be harmful.
• Kidney disease: Monitor closely for potential renal issues.
• Pregnancy: Consult healthcare provider before use.
• Store below 25°C: Keep in the original pack, protect from moisture.

Nicardipine Hydrochloride may interact with other medications, requiring careful management.

Major Interactions (Avoid)

• CYP3A4 inhibitors: May increase nicardipine levels, leading to adverse effects.
• Beta-blockers: Concurrent use may cause excessive hypotension.
• Other antihypertensives: May potentiate blood pressure-lowering effects.

Moderate Interactions (Monitor Closely)

• CYP3A4 inducers: May decrease nicardipine effectiveness.
• Digoxin: Monitor for signs of digoxin toxicity.
• Cyclosporine: May increase cyclosporine levels.