Product image of Nicardipine Lp Laboratoire X.O (Nicardipine Hydrochloride) supplied by GNH India

Nicardipine Lp Laboratoire X.O

Active Ingredient:
Nicardipine Hydrochloride
Origin:
EU

Nicardipine Lp Laboratoire X.O (Nicardipine Hydrochloride)

Nicardipine Hydrochloride, the active ingredient in Nicardipine Lp Laboratoire X.O, is a calcium channel blocker presented as an oral tablet for oral use. It treats hypertension and chronic stable angina in adult patients.
GNH India supplies Nicardipine Lp Laboratoire X.O as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoire Xo

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Indications & Clinical Uses

Nicardipine Hydrochloride acts on the cardiovascular system to manage elevated blood pressure and angina symptoms.

  • Hypertension: lowers systemic arterial pressure and reduces cardiovascular risk.
  • Chronic stable angina: decreases frequency of chest pain episodes by improving myocardial oxygen supply.
  • Hypertensive emergencies: provides controlled reduction of blood pressure when rapid control is needed.

How It Works

  • Nicardipine Hydrochloride selectively blocks L‑type calcium channels in vascular smooth muscle, inhibiting calcium influx. This causes arterial vasodilation, reduces peripheral resistance, and lowers blood pressure while also improving coronary blood flow, which alleviates angina.

Side Effects

Adverse reactions may occur with nicardipine therapy.

Common Side Effects

  • Headache: mild to moderate pain often occurring early in treatment.
  • Flushing: transient warmth and redness of the skin.
  • Peripheral edema: swelling of ankles or lower legs.
  • Dizziness: sensation of light‑headedness, especially upon standing.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Myocardial infarction: rare occurrence of heart attack.
  • Allergic reaction: rash, itching, or anaphylaxis in susceptible individuals.

Precautions & Warnings

Before initiating nicardipine, clinicians should consider several safety measures.

  • Blood pressure monitoring: ensure adequate control and avoid excessive drops.
  • Cardiac assessment: evaluate for underlying heart failure or recent myocardial infarction.
  • Concomitant antihypertensives: adjust doses to prevent additive hypotensive effects.
  • Hepatic impairment: use with caution in patients with liver dysfunction.
  • Discontinuation: avoid abrupt cessation to prevent rebound hypertension.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Nicardipine may interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): increase nicardipine plasma levels.
  • Other calcium channel blockers: additive vasodilatory effect leading to hypotension.
  • Nitrates: risk of severe hypotension when combined.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance blood‑pressure‑lowering effect.
  • ACE inhibitors or ARBs: monitor for excessive blood pressure reduction.

Frequently Asked Questions

Nicardipine Lp is prescribed to lower high blood pressure (hypertension) and to relieve chest pain caused by chronic stable angina. It works by relaxing blood vessels, which improves blood flow and reduces the heart's workload.

Nicardipine Hydrochloride blocks L‑type calcium channels in the smooth muscle of arteries. By preventing calcium entry, it causes the vessels to dilate, decreasing peripheral resistance and lowering blood pressure while also enhancing coronary blood flow to ease angina.

The specific dose of Nicardipine Lp is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and other individual factors. Dosage adjustments are made according to clinical judgment and monitoring.

Safety data for Nicardipine in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and under medical supervision.

To request Nicardipine Lp, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nicardipine belongs to the dihydropyridine calcium‑channel blocker class, which primarily causes arterial vasodilation. Compared with beta‑blockers or ACE inhibitors, it has a more pronounced effect on peripheral resistance and may be preferred when rapid blood‑pressure reduction or improvement of coronary flow is needed.

Nicardipine Lp should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and excessive heat to maintain its stability and potency.

Nicardipine Lp is taken orally, usually as a tablet, with or without food as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed.

The most serious risks include severe hypotension, which can cause fainting or organ hypoperfusion, and rare occurrences of myocardial infarction or serious allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience symptoms like extreme dizziness, chest pain, or swelling of the face and throat.

Nicardipine Lp is contraindicated in patients with known hypersensitivity to nicardipine or any component of the formulation, and in those with severe aortic stenosis or uncontrolled heart failure. Caution is also advised for individuals with significant liver disease or those taking interacting medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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