Product image of Nicergolin (Nicergoline) supplied by GNH India

Nicergolin

Active Ingredient:
Nicergoline
Origin:
EU

Nicergolin (Nicergoline)

Nicergoline, the active ingredient in Nicergolin, is an ergot‑derived cerebral vasodilator presented as an oral tablet. It is used to improve cerebral blood flow and neuronal metabolism in elderly patients with cognitive impairment, in vascular dementia, and in other cerebral circulatory disorders where enhanced perfusion is desired.

GNH India supplies Nicergolin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring EU‑quality standards and reliable global distribution. The company provides full regulatory documentation and supports import logistics for institutional buyers.

Manufacturer / TM Owner

Farmaceutyczna Spoldzielnia Pracy Filofarm

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Indications & Clinical Uses

Nicergolin acts on cerebral vascular function and is employed in several neurologic conditions.

  • Cognitive impairment in the elderly: improves cerebral perfusion and may support memory and attention functions.
  • Vascular dementia: helps maintain blood flow to brain regions affected by vascular injury, potentially slowing cognitive decline.
  • Cerebral circulatory disorders: enhances overall cerebral blood supply, aiding symptoms related to reduced perfusion.

How It Works

  • Nicergoline exerts its effect primarily as a partial agonist at serotonin 5‑HT1 receptors and as an antagonist at peripheral α‑adrenergic receptors. This dual activity leads to vasodilation of cerebral arteries, reduced platelet aggregation, and improved neuronal metabolism. The resulting increase in cerebral blood flow supports oxygen and nutrient delivery to brain tissue, which underlies its therapeutic use in cognitive and vascular disorders.

Side Effects

Nicergoline may be associated with a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Dizziness or vertigo: especially on standing.
  • Gastrointestinal upset: nausea, abdominal discomfort.
  • Flushing: transient skin redness.
  • Nasal congestion: mild blockage of nasal passages.

Serious or Rare Side Effects

  • Hypotension: marked drop in blood pressure.
  • Cardiac arrhythmias: irregular heart rhythm.
  • Hepatic dysfunction: elevated liver enzymes.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.

Precautions & Warnings

When prescribing Nicergolin, clinicians should consider several precautionary measures to ensure safe use.

  • Cardiovascular assessment: evaluate for existing hypertension or hypotension.
  • Liver function monitoring: check baseline hepatic enzymes.
  • Renal function: assess kidney status in patients with impairment.
  • Concomitant vasodilators: avoid additive blood‑pressure‑lowering effects.
  • Elderly patients: start at lower dose and monitor for dizziness.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in original container.

Avoid Interactions

Nicergoline can interact with other medicines, influencing its efficacy or safety profile.

Major Interactions (Avoid)

  • Antihypertensive agents: may cause excessive blood pressure reduction.
  • Phosphodiesterase‑5 inhibitors: increased risk of hypotension.
  • Other ergot derivatives: heightened risk of vasospasm and toxicity.

Moderate Interactions (Monitor Closely)

  • Antiplatelet or anticoagulant drugs: enhanced bleeding tendency.
  • CYP450 inhibitors: possible increase in Nicergoline plasma levels.
  • CNS depressants: may augment dizziness or sedation.

Frequently Asked Questions

Nicergolin is prescribed to improve cerebral blood flow in conditions such as age‑related cognitive impairment, vascular dementia, and other cerebral circulatory disorders where enhanced perfusion may support neurological function.

Nicergoline acts as a partial agonist at serotonin 5‑HT1 receptors and blocks peripheral α‑adrenergic receptors. This combination produces dilation of cerebral vessels, reduces platelet aggregation, and boosts neuronal metabolism, thereby increasing oxygen and nutrient delivery to brain tissue.

The appropriate dose of Nicergolin is determined by the prescribing clinician based on the individual patient's condition, age, and response. Dosage regimens are not standardized and should follow the prescriber’s instructions.

Safety data for Nicergolin during pregnancy and lactation are limited. Because the risk cannot be ruled out, it should only be used if the potential benefit justifies the potential risk to the fetus or infant, and under medical supervision.

To order Nicergolin, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with other cerebral vasodilators such as pentoxifylline, Nicergolin has a distinct mechanism involving serotonin 5‑HT1 agonism and α‑adrenergic antagonism, which may provide a broader effect on cerebral blood flow and platelet function. Clinical choice depends on patient profile, tolerability and physician preference.

Nicergolin tablets should be stored at ambient temperature, preferably below 25 °C, in their original packaging to protect from moisture and light. Keep the product out of reach of children and avoid exposure to extreme heat or humidity.

Nicergolin is taken orally, usually with a glass of water. It is recommended to follow the prescribing physician’s guidance regarding timing (e.g., with or without food) and to avoid crushing or chewing the tablet unless specifically instructed.

Serious adverse events include marked hypotension, cardiac arrhythmias, significant liver enzyme elevations, and severe allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience symptoms like fainting, irregular heartbeat, jaundice, or widespread rash.

Nicergolin is contraindicated in patients with known hypersensitivity to ergot derivatives, uncontrolled hypertension, severe liver disease, or those taking other ergot medications. Caution is also advised for individuals with a history of cardiac arrhythmias or significant hypotension.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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