Product image of Nicergolină Lph (Nicergoline) supplied by GNH India

Nicergolină Lph

Active Ingredient:
Nicergoline
Origin:
EU

Nicergolină Lph (Nicergoline)

Nicergoline, the active ingredient in Nicergolină Lph, is an ergot alkaloid presented as an oral tablet for oral use. It is used to improve cerebral blood flow in patients with cognitive impairment related to cerebrovascular disease, dementia, and peripheral vascular disease.

GNH India supplies Nicergolină Lph as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Labormed Pharma S.A.

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Indications & Clinical Uses

Nicergoline is employed as a cerebral vasodilator to address disorders involving reduced cerebral perfusion.

  • Cognitive impairment associated with cerebrovascular disease: improves cerebral blood flow and may support cognitive function.
  • Dementia: helps maintain cerebral circulation which can aid symptom management.
  • Peripheral vascular disease: enhances peripheral blood flow and reduces ischemic symptoms.

How It Works

  • Nicergoline is an ergot derivative that antagonizes alpha‑adrenergic receptors, producing vasodilation of cerebral and peripheral vessels. It stimulates endothelial nitric oxide release, increasing blood flow, and inhibits platelet aggregation, thereby improving microcirculatory perfusion without significant sympathetic stimulation.

Side Effects

Nicergoline may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Dizziness: sensation of light‑headedness, especially on standing.
  • Headache: transient cranial discomfort.
  • Gastrointestinal upset: abdominal pain or dyspepsia.
  • Hypotension: mild reduction in blood pressure.

Serious or Rare Side Effects

  • Hepatic enzyme elevation: possible liver function abnormalities.
  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Cardiac arrhythmia: irregular heart rhythm events.
  • Allergic reactions: rash, pruritus, or anaphylaxis in rare cases.

Precautions & Warnings

Before initiating Nicergolină Lph, clinicians should consider several safety aspects.

  • Renal or hepatic impairment: monitor liver and kidney function regularly.
  • Elderly patients: observe for exaggerated hypotensive responses.
  • Concomitant antihypertensives: risk of additive blood‑pressure lowering.
  • History of migraine: may exacerbate headache symptoms.
  • Pregnancy and lactation: use only if clearly needed after risk‑benefit assessment.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Nicergoline can interact with several drug classes; interactions are grouped by clinical significance.

Major Interactions (Avoid)

  • Other ergot derivatives: additive risk of vasospasm.
  • Potent CYP3A4 inhibitors (e.g., ketoconazole): increased plasma concentrations.
  • Anticoagulants: enhanced bleeding tendency.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: may potentiate hypotensive effect.
  • SSRIs or SNRIs: possible increased bleeding risk.
  • Alcohol: may intensify dizziness and hypotension.

Frequently Asked Questions

Nicergolină Lph contains nicergoline, a cerebral vasodilator indicated for cognitive impairment linked to cerebrovascular disease, certain forms of dementia, and peripheral vascular disease. By increasing blood flow to the brain and peripheral tissues, it aims to support neurological function and reduce ischemic symptoms.

Nicergoline antagonizes alpha‑adrenergic receptors, causing dilation of cerebral and peripheral vessels. It also promotes nitric oxide release from the endothelium and inhibits platelet aggregation, which together enhance microcirculatory blood flow and improve oxygen delivery to affected tissues.

The prescribed dose of Nicergolină Lph is determined by the treating physician based on the individual’s clinical condition, age, and response to therapy. Dosage regimens may vary, and patients should follow the prescriber’s instructions without self‑adjusting the amount.

Safety data for nicergoline during pregnancy and lactation are limited. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nicergoline is an ergot‑derived vasodilator, distinct from agents such as pentoxifylline or cilostazol, which act primarily through phosphodiesterase inhibition. Compared with other ergot alkaloids, nicergoline has a lower propensity for severe vasospasm but shares similar mechanisms of alpha‑adrenergic antagonism and platelet inhibition.

Nicergolină Lph should be stored at ambient temperature below 25 °C, in its original packaging, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid exposing it to extreme temperatures.

Nicergolină Lph is taken orally, usually with a glass of water. It may be administered with or without food, but patients should follow the prescriber’s guidance regarding timing relative to meals to minimize gastrointestinal discomfort.

Serious adverse events, though rare, include significant hypotension, hepatic enzyme elevation, cardiac arrhythmias, and severe allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience symptoms like fainting, chest pain, jaundice, or widespread rash.

Nicergoline is contraindicated in patients with known hypersensitivity to ergot alkaloids, uncontrolled hypertension, active coronary artery disease, severe hepatic impairment, and in individuals who are pregnant or breastfeeding unless clearly indicated. It should also be avoided in patients taking other ergot derivatives.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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