Product image of Nicobion (Nicotinamide) supplied by GNH India

Nicobion

Active Ingredient:
Nicotinamide
Origin:
EU

Nicobion (Nicotinamide)

Nicotinamide, the active ingredient in Nicobion, is a vitamin B3 (niacin) derivative presented as a tablet for oral use. It helps prevent and treat niacin (vitamin B3) deficiency, supports skin health by contributing to barrier function, and provides general metabolic support through its role in cellular energy and DNA repair processes in adults.

GNH India supplies Nicobion as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across global markets.

Manufacturer / TM Owner

Teofarma S.R.L.

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Indications & Clinical Uses

Nicotinamide, a vitamin B3 derivative, is used to address conditions related to niacin deficiency, skin health, and metabolic function.

  • Niacin deficiency: restores normal vitamin B3 levels and prevents symptoms such as pellagra.
  • Skin health: supports epidermal barrier integrity and may improve appearance of acne or dermatitis.
  • Metabolic support: contributes to cellular energy production and DNA repair processes.

How It Works

  • After oral absorption, nicotinamide is converted into nicotinamide adenine dinucleotide (NAD+) and NADP+, essential co‑enzymes in redox reactions. These nucleotides participate in cellular energy metabolism, oxidative phosphorylation, and DNA repair via poly‑ADP‑ribose polymerase. By replenishing intracellular NAD+ pools, nicotinamide supports metabolic pathways, gene expression regulation, and skin cell function without causing the flushing associated with niacin.

Side Effects

Nicotinamide may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild stomach upset reported in some users.
  • Headache: transient headaches may occur.
  • Mild flushing: occasional skin warmth, less intense than with niacin.

Serious or Rare Side Effects

  • Liver enzyme elevation: may indicate hepatic stress; monitor liver function.
  • Severe hypersensitivity: rash, swelling, or anaphylaxis requiring immediate medical attention.
  • Blood glucose alterations: can affect glycemic control in diabetic patients.

Precautions & Warnings

When using Nicobion, consider the following precautions to ensure safe and effective use.

  • Pregnancy: safety not established; use only if potential benefit justifies risk.
  • Breastfeeding: insufficient data; weigh benefits against possible infant exposure.
  • Liver disease: monitor hepatic function regularly during therapy.
  • Diabetes: nicotinamide may affect blood glucose; monitor levels closely.
  • Drug interactions: review concomitant medications for potential interactions.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Nicotinamide can interact with several medicines; awareness of major and moderate interactions helps avoid adverse outcomes.

Major Interactions (Avoid)

  • High‑dose niacin: combined use may increase risk of liver toxicity.
  • Carbamazepine: enzyme induction may reduce nicotinamide effectiveness.
  • Methotrexate: possible antagonistic effect on therapeutic action.

Moderate Interactions (Monitor Closely)

  • Antidiabetic agents: nicotinamide may alter glucose control; monitor blood sugar.
  • Antihypertensive drugs: additive hypotensive effect may occur.
  • Alcohol: concurrent use can increase hepatic stress.

Frequently Asked Questions

Nicobion contains nicotinamide, a form of vitamin B3, and is used to prevent and treat niacin (vitamin B3) deficiency, support skin health by aiding barrier function, and provide general metabolic support through its role in cellular energy production and DNA repair.

Nicotinamide serves as a precursor for NAD+ and NADP+, co‑enzymes essential for redox reactions, energy metabolism, and DNA repair. By increasing intracellular NAD+ levels, it helps maintain cellular energy balance, supports metabolic pathways, and promotes healthy skin cell function.

The appropriate dose of Nicobion is determined by a qualified healthcare professional based on the individual’s age, health status, and therapeutic need. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for nicotinamide in pregnancy and lactation are limited. It should be used only if the potential benefit outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare provider.

To order Nicobion, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nicobion provides nicotinamide, which does not cause the flushing associated with nicotinic acid (niacin). While both address niacin deficiency, nicotinamide is preferred when a non‑flushing option is needed, whereas niacin may be chosen for its lipid‑modifying effects.

Nicobion should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct light, and ensure they are out of reach of children.

Nicobion is taken orally, usually with water. It can be taken with or without food, but following the prescriber’s specific instructions regarding timing and any accompanying meals is recommended.

Serious risks, though uncommon, include liver enzyme elevation indicating possible hepatic injury, severe hypersensitivity reactions such as rash or anaphylaxis, and alterations in blood glucose control, especially in patients with diabetes. Prompt medical attention is required if any of these occur.

Individuals with known hypersensitivity to nicotinamide or any tablet excipients should avoid Nicobion. Patients with severe liver disease, uncontrolled diabetes, or those taking medications that may interact significantly should consult a healthcare professional before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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