Product image of Nicorandil Rivopharm (Nicorandil) supplied by GNH India

Nicorandil Rivopharm

Active Ingredient:
Nicorandil
Origin:
EU

Nicorandil Rivopharm (Nicorandil)

Nicorandil, the active ingredient in Nicorandil Rivopharm, is a nitrate vasodilator presented as an oral tablet for oral use. It treats stable angina pectoris in adult patients by improving myocardial blood flow and reducing cardiac workload.

GNH India supplies Nicorandil Rivopharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Holsten Pharma Gmbh

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Nicorandil acts on the coronary circulation and peripheral vasculature to relieve anginal symptoms.
  • Stable angina pectoris: reduces frequency and severity of chest pain episodes by lowering cardiac preload and afterload.

How It Works

  • Nicorandil provides nitrate‑like vasodilation by releasing nitric oxide, which relaxes smooth muscle in arteries and veins. It also activates ATP‑sensitive potassium channels, leading to hyperpolarization of vascular smooth muscle cells. The combined arterial and venous dilation decreases cardiac preload and afterload, improving myocardial oxygen balance and alleviating angina.

Side Effects

Nicorandil may cause a range of adverse reactions.

Common Side Effects

  • Headache: mild to moderate, often transient.
  • Flushing: warmth and redness of the skin.
  • Dizziness or light‑headedness, especially on standing.
  • Nausea or abdominal discomfort.
  • Palpitations: awareness of heartbeats.
  • Mild hypotension: lower blood pressure without severe symptoms.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Exacerbation of angina or myocardial infarction.
  • Stevens‑Johnson syndrome or severe skin reactions.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Hepatic dysfunction: abnormal liver enzymes.
  • Life‑threatening arrhythmias.

Precautions & Warnings

  • Before initiating Nicorandil, consider the following safety measures.
  • Cardiovascular assessment: evaluate for recent myocardial infarction or unstable angina.
  • Renal impairment: adjust therapy if severe kidney disease is present.
  • Hepatic dysfunction: monitor liver function tests regularly.
  • Concomitant nitrates or PDE5 inhibitors: avoid combined use due to risk of profound hypotension.
  • Pregnancy and breastfeeding: safety not established; use only if benefits outweigh risks.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture.

Avoid Interactions

Nicorandil can interact with several medication classes.

Major Interactions (Avoid)

  • Other nitrates: additive vasodilation may cause severe hypotension.
  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil): risk of marked blood pressure fall.
  • Potent vasodilators (e.g., hydralazine): may amplify hypotensive effects.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (ACE inhibitors, ARBs, beta‑blockers): monitor blood pressure.
  • Diuretics: assess for volume depletion and orthostatic changes.
  • Calcium channel blockers: watch for additive cardiovascular effects.
  • Other anti‑anginal agents (e.g., ranolazine): evaluate overall symptom control.
  • Antiplatelet or anticoagulant therapy: monitor for bleeding tendencies.

Frequently Asked Questions

Nicorandil Rivopharm is prescribed to manage stable angina pectoris. It helps relieve chest pain by improving blood flow to the heart and reducing the workload on the myocardium, making it useful for patients with chronic, exertion‑related anginal symptoms.

Nicorandil combines two mechanisms: it releases nitric oxide, producing nitrate‑like vasodilation of arteries and veins, and it opens ATP‑sensitive potassium channels, causing smooth‑muscle relaxation. Together, these actions lower cardiac preload and afterload, enhancing oxygen delivery to heart muscle.

The dosage of Nicorandil Rivopharm is determined by the prescribing clinician based on the individual’s clinical condition, response, and tolerance. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for Nicorandil in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nicorandil is unique because it offers both nitrate‑like vasodilation and potassium‑channel activation, whereas many other anti‑anginals rely on a single mechanism such as beta‑blockade or calcium‑channel blockade. This dual action can provide additional symptom relief for patients who do not respond adequately to conventional agents.

Nicorandil Rivopharm should be stored at ambient temperature below 25 °C, in its original packaging, and protected from moisture and direct sunlight. Maintaining these conditions helps preserve the tablet’s stability and potency.

Nicorandil Rivopharm is taken orally, usually with or without food, as directed by the prescriber. The tablets should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed.

The most serious risks include severe hypotension, worsening of angina or myocardial infarction, life‑threatening skin reactions such as Stevens‑Johnson syndrome, and rare hepatic dysfunction. Patients should seek immediate medical attention if they experience any of these severe symptoms.

Nicorandil is contraindicated in patients with known hypersensitivity to the drug, those taking other nitrates or PDE‑5 inhibitors, and individuals with severe hypotension or recent myocardial infarction without medical supervision. Clinicians must evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Nicorandil

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT