Product image of Nicorandil Viatris (Nicorandil) supplied by GNH India

Nicorandil Viatris

Active Ingredient:
Nicorandil
Origin:
EU

Nicorandil Viatris (Nicorandil)

Nicorandil, the active ingredient in Nicorandil Viatris, is a potassium channel opener / nitrate presented as an oral tablet for oral use. It treats stable angina pectoris in adult patients by reducing chest pain episodes and improving exercise tolerance.

GNH India supplies Nicorandil Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Sante

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Indications & Clinical Uses

Nicorandil is used in the management of coronary artery disease and related angina syndromes.

  • Stable angina pectoris: reduces the frequency of chest pain attacks and improves exercise capacity.
  • Chronic stable angina: decreases myocardial oxygen demand and alleviates ischemic symptoms.
  • Ischemic heart disease: helps relieve myocardial ischemia associated with angina.

How It Works

  • Nicorandil donates nitric oxide, leading to cyclic GMP‑mediated smooth‑muscle relaxation, and simultaneously opens ATP‑sensitive potassium channels in vascular smooth muscle. The combined arterial and venous dilation lowers both preload and afterload, thereby reducing cardiac workload and improving myocardial oxygen balance in patients with angina.

Side Effects

Nicorandil may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Headache: mild to moderate, often transient.
  • Flushing: warmth and redness of the skin.
  • Dizziness or light‑headedness, especially on standing.
  • Nausea or abdominal discomfort.
  • Palpitations or tachycardia.
  • Mild hypotension: reduced blood pressure without syncope.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure causing fainting.
  • Myocardial infarction: rare worsening of heart attack risk.
  • Stevens‑Johnson syndrome or severe skin reactions.
  • Angina exacerbation or new‑onset chest pain.
  • Anaphylactic or severe allergic reactions.
  • Hepatic dysfunction: abnormal liver enzymes.

Precautions & Warnings

Before initiating Nicorandil therapy, consider the following safety measures.

  • Contraindication: severe hypotension or cardiogenic shock.
  • Avoid use with other nitrates or potent vasodilators.
  • Caution in recent myocardial infarction: monitor cardiac status.
  • Monitor blood pressure regularly, especially after dose changes.
  • Pregnancy and lactation: safety not established; use only if benefit outweighs risk.
  • Discontinue gradually: abrupt cessation may precipitate rebound angina.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Nicorandil can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil): risk of profound hypotension.
  • Other nitrates or nitrovasodilators: additive vasodilatory effect.
  • Potent vasodilators (e.g., hydralazine): may cause severe blood pressure drops.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (ACE inhibitors, ARBs, beta‑blockers): monitor for additive blood pressure lowering.
  • Diuretics: may enhance hypotensive response.
  • Calcium channel blockers: observe for synergistic vasodilation.
  • Alcohol: can increase dizziness and hypotension.
  • Antiplatelet agents: watch for bleeding tendency.

Frequently Asked Questions

Nicorandil Viatris is prescribed to manage stable angina pectoris, a condition characterized by chest pain due to reduced blood flow to the heart. It helps relieve symptoms, decrease the frequency of angina attacks, and improve exercise tolerance in adult patients with coronary artery disease.

Nicorandil combines two mechanisms: it releases nitric oxide, which relaxes vascular smooth muscle, and it opens ATP‑sensitive potassium channels, causing arterial and venous dilation. This dual action reduces cardiac preload and afterload, lowering myocardial oxygen demand and alleviating angina.

The specific dose of Nicorandil Viatris is determined by the prescribing healthcare professional based on the patient’s clinical condition, response, and tolerance. Dosage adjustments are made individually, and patients should follow the prescriber’s instructions without self‑adjusting the amount.

Safety data for Nicorandil in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nicorandil is unique because it combines nitrate‑like nitric‑oxide donation with potassium‑channel activation, offering both arterial and venous dilation. Compared with pure nitrates or beta‑blockers, it may provide additional symptom relief without the same degree of tolerance development, but individual response varies.

Nicorandil Viatris should be stored below 25 °C in its original packaging, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid storing it in humid or excessively hot environments to maintain stability.

Nicorandil Viatris is taken orally, usually as a tablet, with or without food as directed by the prescriber. The exact administration schedule, such as once or twice daily, is individualized based on the patient’s condition and therapeutic response.

Serious risks include severe hypotension, which can cause fainting, and rare but serious skin reactions such as Stevens‑Johnson syndrome. In rare cases, worsening angina or myocardial infarction may occur. Patients should seek immediate medical attention if they experience sudden severe chest pain, fainting, or extensive rash.

Nicorandil is contraindicated in patients with severe hypotension, cardiogenic shock, or recent myocardial infarction. Individuals taking other nitrates, PDE‑5 inhibitors, or potent vasodilators should avoid it unless closely supervised. Pregnant or breastfeeding women should only use it when clearly indicated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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