Nicorette Classic (Nicotine)

Nicorette Classic is used in nicotine replacement therapy to support smoking cessation.

• Smoking cessation: helps adult smokers quit by alleviating withdrawal symptoms and reducing cravings.
• Tobacco dependence: provides a controlled nicotine dose to replace cigarettes during the quitting process.
• Relapse prevention: assists individuals who have recently quit smoking to maintain abstinence.

• Nicotine in Nicorette Classic is absorbed through the oral mucosa, where it binds to nicotinic acetylcholine receptors on neuronal cells. This activation mimics the pharmacologic effect of inhaled nicotine, delivering a lower, steady plasma concentration that reduces the intensity of withdrawal and craving. By providing controlled nicotine exposure, the product facilitates the gradual reduction of dependence while allowing the user to wean off nicotine over time.

Common and serious adverse reactions may occur with Nicorette Classic, although many users experience no problems.

Common Side Effects

• Mouth irritation: mild soreness or tingling in the oral cavity.
• Nausea: transient feeling of queasiness after use.
• Hiccups: brief episodes of involuntary diaphragm contraction.
• Heartburn: occasional acid reflux symptoms.
• Headache: mild to moderate headache.
• Dyspepsia: indigestion or stomach discomfort.

Serious or Rare Side Effects

• Allergic reaction: rash, itching, swelling, or difficulty breathing.
• Chest pain: unexpected thoracic discomfort that may indicate cardiac issues.
• Severe dizziness: pronounced light‑headedness or loss of balance.
• Hypertension: sudden increase in blood pressure.
• Persistent vomiting: ongoing emesis requiring medical attention.
• Severe nausea: prolonged or intense nausea that interferes with daily activities.

Before using Nicorette Classic, consider the following precautions to ensure safe and effective use.

• Cardiovascular disease: consult a healthcare professional if you have heart conditions, as nicotine may affect heart rate and blood pressure.
• Diabetes: monitor blood glucose levels, as nicotine can influence insulin sensitivity.
• Pregnancy: discuss risks with a physician; nicotine exposure may affect fetal development.
• Breastfeeding: seek medical advice before use, as nicotine can be transferred to breast milk.
• Medication interactions: inform your doctor of all concurrent drugs, especially MAO inhibitors or antihypertensives.
• Store at ambient temperature: keep the lozenges in the original packaging, protect from moisture and heat.

Nicotine may interact with several medicines; awareness of these interactions helps prevent adverse effects.

Major Interactions (Avoid)

• MAO inhibitors: combined use can cause hypertensive crisis.
• Beta‑blockers: nicotine may mask tachycardia, complicating cardiovascular monitoring.
• Antidepressants (SSRIs, SNRIs): increased risk of side effects such as agitation or insomnia.

Moderate Interactions (Monitor Closely)

• Caffeine: concurrent use may enhance stimulant effects, leading to jitteriness.
• Alcohol: nicotine can intensify intoxication and impair judgment.
• Insulin or oral hypoglycemics: nicotine may affect glucose control, requiring dose adjustments.