Nicorette Freshfruit Z Okusom Sadja (Nicotine)

Nicotine, a nicotine replacement therapy, is used to support smoking cessation by addressing nicotine dependence.

• Smoking cessation: reduces withdrawal symptoms and cravings, facilitating gradual reduction of tobacco use.
• Relapse prevention: helps maintain abstinence after quitting by providing controlled nicotine exposure.
• Tobacco dependence: offers a regulated nicotine source to replace cigarettes during the quitting process.

• Nicotine acts as an agonist at nicotinic acetylcholine receptors in the central nervous system, particularly the α4β2 subtype. By stimulating these receptors, it mimics the pharmacologic effects of tobacco‑derived nicotine, thereby decreasing the intensity of withdrawal symptoms and cravings associated with smoking cessation, while allowing a gradual tapering of nicotine exposure.

Nicotine replacement therapy can cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

• Mouth irritation: soreness or tingling in the oral cavity.
• Throat irritation: discomfort or scratchy sensation.
• Nausea: mild upset stomach.
• Headache: occasional tension‑type headache.
• Dizziness: light‑headed feeling.
• Hiccups: brief episodes of involuntary diaphragm contraction.

Serious or Rare Side Effects

• Allergic reaction: rash, itching, swelling, or difficulty breathing.
• Chest pain: unexpected discomfort that may indicate cardiac involvement.
• Irregular heartbeat: palpitations or arrhythmia.
• Severe mouth ulcer: persistent ulceration beyond normal irritation.
• High blood pressure: significant elevation requiring medical attention.

When using Nicorette Freshfruit Z Okusom Sadja, consider the following safety measures.

• Cardiovascular assessment: nicotine may increase heart rate and blood pressure, so evaluate patients with heart disease.
• Pregnancy and lactation: safety has not been established; use only if benefits outweigh risks.
• Diabetes monitoring: nicotine can affect glucose control; monitor blood sugar levels.
• Concomitant nicotine use: avoid using other nicotine products to prevent excess exposure.
• Storage: Store at ambient temperature below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Nicotine may interact with several medicines, altering their efficacy or safety profile.

Major Interactions (Avoid)

• Monoamine oxidase inhibitors (MAOIs): may potentiate nicotine’s sympathomimetic effects.
• Warfarin: nicotine can affect metabolism, potentially altering anticoagulant control.
• Insulin or oral hypoglycemics: nicotine may impair glucose regulation, requiring dose adjustments.

Moderate Interactions (Monitor Closely)

• Beta‑blockers: monitor for exaggerated bradycardia or hypotension.
• Antidepressants (SSRIs, SNRIs): observe for increased side effects such as insomnia or agitation.
• Caffeine-containing products: nicotine can enhance stimulant effects, leading to jitteriness.