Nicorette Mint Spray Buccal (Nicotine)

Nicotine replacement therapy acts on the nicotinic acetylcholine receptor pathway to reduce dependence on tobacco smoke.

• Smoking cessation: helps adult smokers gradually reduce nicotine cravings and withdrawal symptoms while transitioning away from cigarettes.
• Tobacco dependence: supports individuals attempting to quit any form of tobacco use by providing controlled nicotine delivery.

• Nicotine in the buccal spray is absorbed through the oral mucosa and binds to nicotinic acetylcholine receptors in the central nervous system. This activation mimics the pharmacologic effects of inhaled tobacco nicotine, decreasing withdrawal symptoms and cravings while allowing a gradual reduction in nicotine exposure.

Nicotine spray may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

• Mouth irritation: mild soreness or tingling in the oral cavity.
• Throat irritation: discomfort or scratchy sensation.
• Nausea: feeling of queasiness after use.
• Dizziness: light‑headed feeling, especially when standing quickly.
• Cough: occasional dry cough after spraying.
• Hiccups: brief episodes of involuntary diaphragm contraction.

Serious or Rare Side Effects

• Allergic reaction: rash, itching, swelling, or difficulty breathing.
• Severe mouth ulceration: persistent ulcer or lesion in the buccal area.
• Chest pain: unexplained discomfort that may indicate cardiac involvement.
• Irregular heartbeat: palpitations or arrhythmia.
• Hypertensive crisis: sudden, severe increase in blood pressure.
• Seizures: rare neurologic events requiring immediate medical attention.

Before using Nicotine buccal spray, consider the following safety measures.

• Contraindication: Do not use if you have a known hypersensitivity to nicotine or any excipients.
• Cardiovascular disease: Use with caution if you have recent heart attack, uncontrolled hypertension, or serious arrhythmias.
• Pregnancy and lactation: Consult a healthcare professional; benefits must outweigh potential risks.
• Non‑smokers: Not intended for individuals who do not regularly use tobacco products.
• Children: Keep out of reach of children and pets; accidental ingestion can be harmful.
• Store at room temperature: Keep below 25 °C, in the original packaging, protected from moisture and direct sunlight.

Nicotine spray can interact with other substances, altering its safety or effectiveness.

Major Interactions (Avoid)

• Other nicotine products (patches, gum, lozenges): risk of nicotine overdose leading to severe toxicity.
• Monoamine oxidase inhibitors (MAOIs): may increase cardiovascular strain and hypertensive episodes.

Moderate Interactions (Monitor Closely)

• Caffeine: may enhance stimulant effects, causing increased heart rate or jitteriness.
• Alcohol: can intensify nicotine’s central effects and impair judgment.
• Certain antihypertensive agents: nicotine may counteract blood‑pressure‑lowering effects.
• Antipsychotic medications: nicotine can affect metabolism, potentially altering drug levels.
• Herbal supplements containing nicotine (e.g., certain teas): may contribute to cumulative nicotine exposure.